A STUDY ON POTENTIAL DRUG - DRUG INTERACTIONS IN MEDICINE DEPARTMENT OF A MULTI SPECIALTY TEACHING HOSPITAL

Objective: To identify frequency, type, severity and predictors of potential drug-drug interactions(pDDIs), potential drug-food interactions(pDFIs), potential drug-alcohol interactions(pDAIs) and potential drug-tobacco interactions(pDTIs) and most frequently interacting drug combination pairs in hospitalized patients from departments(depts) of General Medicine(GM), Orthopedic(Ortho), Gynecology(OBG), Pulmonology(Pulmo), General Surgery (GS), Psychiatry (Psych), Otolaryngology(ENT) and Dermatology (Derm) of study population. Methods: A Prospective Observational Study was conducted in eight major dept's of a tertiary care teaching hospital for a period of 6 mo. A sample size of 650 prescriptions reflecting admission no's for each department were used. Results: A total of 650 patients were included in the study. Among them, 282(43.4%) were males and 368(56.6%) were females. The mean age of the study population was 39.67±15.23. A total of 487 pDDIs, 734 pDFIs, 586 pDAIs and 159 pDTIs were found out of 650 hospitalized episodes. OBG showed the highest pDDIs and pDAIs. Highest pDFIs and pDTIs were seen in Pulmo. The majority of DDIs were minor, DFIs and DAIs were moderate and DTIs were of major in severity. Pharmacokinetic types of interactions were seen in the majority of the depts. Logistic regression analysis showed that Polypharmacy was associated with the occurrence of DIs. Most of the DIs repeated several times in particular depts and a list of these combinations was prepared. Conclusion: With the high occurrence of overall DIs and characteristic patterns of DIs combination pairs among different departments of the hospital, the presence of clinical pharmacists in hospitals can play a great role, especially in developing nations like India where their role in hospitalized settings is always controversial.

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PREVALENCE OF HYPERTENSION AND POTENTIAL DRUG-DRUG INTERACTIONS AMONG CHRONIC HEART FAILURE PATIENTS MANAGED AT LAGOS UNIVERSITY TEACHING HOSPITAL, NIGERIA

CHEST Journal ◽

10.1016/j.chest.2019.08.140 ◽

2019 ◽

Vol 156 (4) ◽

pp. A39

Author(s):

Uzochukwu Ofonakara ◽

Samuel Olayemi ◽

Kolawale Ale

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Drug Interactions ◽

Teaching Hospital ◽

University Teaching ◽

Potential Drug ◽

Heart Failure Patients

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A study of potential drug-drug interactions among hospitalized cardiac patients in a teaching hospital in Western Nepal

Indian Journal of Pharmacology ◽

10.4103/0253-7613.129303 ◽

2014 ◽

Vol 46 (2) ◽

pp. 152 ◽

Cited By ~ 9

Author(s):

Sushmita Sharma ◽

HimalPaudel Chhetri ◽

Kadir Alam

Keyword(s):

Drug Interactions ◽

Teaching Hospital ◽

Cardiac Patients ◽

Potential Drug

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An exploratory study investigating the potential drug-drug interactions in internal medicine department, Alahsa, Saudi Arabia

Journal of Pharmaceutical Health Services Research ◽

10.1111/jphs.12073 ◽

2014 ◽

Vol 5 (4) ◽

pp. 237-241 ◽

Cited By ~ 3

Author(s):

Yaser Albadr ◽

Abdulaziz Khaled Bohassan ◽

Long Chiau Ming ◽

Tahir Mehmood Khan

Keyword(s):

Internal Medicine ◽

Saudi Arabia ◽

Drug Interactions ◽

Exploratory Study ◽

Potential Drug ◽

Medicine Department ◽

Internal Medicine Department

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Potential Drug-Drug Interactions among Medications Prescribed to Adult Filipinos at a Primary Care Clinic in a Government Teaching Hospital

Acta Medica Philippina ◽

10.47895/amp.v54i3.1642 ◽

2020 ◽

Vol 54 (3) ◽

Author(s):

Shiela Marie S. Laviña ◽

Regie A. Layug

Keyword(s):

Primary Care ◽

Drug Interactions ◽

Teaching Hospital ◽

Medical Records ◽

Primary Care Clinic ◽

Adverse Outcomes ◽

Drug Prescriptions ◽

Potential Drug ◽

Care Clinic ◽

Pharmacokinetic Interactions

Background. A drug-drug interaction (DDI) is a pharmacologic or clinical response to the administration of a drug that can result in adverse outcomes. DDIs are considered preventable adverse drug reactions because these interactions can be learned, predicted and recognized. Objective. To determine potential drug-drug interactions (pDDI) among medications prescribed to adult patients consulting at a primary care clinic in a government teaching hospital. Methods. This was a 6-month retrospective cross-sectional study of drug prescriptions based on medical records of adult Filipinos who were seen and managed at a primary care clinic in a government teaching hospital. Medical charts were systematically selected based on a sampling frame with inclusion and exclusion criteria. Results. A total of 1,490 medical records of adult Filipino patients were included in the study. There were a total of 261 unique prescriptions based on generic formulations and an overall total of 5,978 drugs for a 6-month period of clinic consultations. An average of 4 medications (SD±1.63) were prescribed for every consultation recorded in the medical chart. From the charts that were reviewed, 23% of all adults were given a prescription of 4 drugs (N=348/1490), 26% had 3 drug prescriptions (N=386/1490) and 18% had two drugs, respectively, per clinic visit. Overall, 714/9054 (7.88%) medication pairs were seen to have potential drug interactions. The top three most common drug pairs with pDDI were amlodipine-simvastatin, losartan/hydrochlorothiazide-metformin and aspirin-furosemide. Five hundred twenty-five drug pairs had pharmacodynamic interactions (525/714) while 94 drug pairs (15%) had pharmacokinetic interactions. Conclusion. Potential drug-drug interactions were observed in 8% of medications prescribed to adult Filipinos seen at Family Medicine Clinic in a government hospital. Seventy-four percent (74%) of the drug pairs with pDDIs were pharmacodynamic and 15% were pharmacokinetic interactions.

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