PREVALENCE OF HYPERTENSION AND POTENTIAL DRUG-DRUG INTERACTIONS AMONG CHRONIC HEART FAILURE PATIENTS MANAGED AT LAGOS UNIVERSITY TEACHING HOSPITAL, NIGERIA

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A39
Author(s):  
Uzochukwu Ofonakara ◽  
Samuel Olayemi ◽  
Kolawale Ale
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Drug Interactions ◽  
Teaching Hospital ◽  
University Teaching ◽  
Potential Drug ◽  
Heart Failure Patients

The role of the clinical pharmacist in the prevention of potential drug interactions in geriatric heart failure patients

2019 ◽  
Vol 41 (6) ◽  
pp. 1555-1561
Author(s):  
Kaloyan D. Georgiev ◽  
Nadezhda Hvarchanova ◽  
Marieta Georgieva ◽  
Branimir Kanazirev
Keyword(s):  
Heart Failure ◽  
Drug Interactions ◽  
Clinical Pharmacist ◽  
Potential Drug ◽  
Heart Failure Patients

scholarly journals POTENTIAL DRUG-DRUG INTERACTIONS IN HEART FAILURE PATIENTS

2019 ◽  
pp. 37-41
Author(s):  
Kaloyan Georgiev ◽  
Nadezhda Hvarchanova ◽  
Marieta Georgieva ◽  
Branimir Kanazirev
Keyword(s):  
Heart Failure ◽  
Drug Interactions ◽  
Prescription Drugs ◽  
Adverse Drug Events ◽  
Therapeutic Index ◽  
Potential Drug ◽  
Heart Failure Patients ◽  
Risk Rating ◽  
One Year ◽  
Therapy Modification

Objective: The aim of the present study was to assess the prevalence, risk rating and the severity of hazardous pDDIs (potential drug-drug interactions) in the prescribed pharmacotherapy in the hospital discharged heart failure (HF) patients, primarily with co-administered drugs with narrow therapeutic index (statins, anticoagulants, antithrombotic drugs). Methods: The prescriptions of chronic heart failure patients for one year (January-December 2014) were analyzed for pDDIs through Lexi-interact® software. DDIs belonging to the categories D (Consider therapy modification) and X (Avoid combination) and/or severity of drug interaction-major, were selected for the study. Results: After reviewing the medical records of 985 patients, 239 patients were selected based on the criteria mentioned above. The average number of prescription drugs at hospital discharge was 7.27 medications (±1.84 SD) per patient. The total number of pDDIs was 1483 or approximately 6.2 (±3.89 SD) pDDIs per patient. With respect to the risk rating, in categories D and X were detected 76 (5.12 %) and 2 (0.13 %) pDDI, respectively. The major pDDIs were 108 (7.28 %). Conclusion: HF patients are at high risk of pDDIs. Screening of prescriptions for pDDIs and monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.

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