SYNTHESIS AND MOLECULAR DOCKING ANALYSIS OF OXAZETIDINE DERIVATIVES FOR NEUROLOGICAL DISORDERS
2021 ◽
Vol 10
(4)
◽
pp. 3291-3295
Keyword(s):
A series of Oxazetidine (NL1-NL12) from reacting tryptophan and aromatic aldehydes were synthesized in good yields by involving 2-{[(4-chlorophenyl) methylidene] amino}-3-(1H-indol-3-yl) propanoic acid and chloro acetyl chloride as reactive intermediates. All the synthesized derivatives were screened via spectral techniques. Synthesized molecules were virtually screened against Human A2A Adenosine receptor interactions analysis using molecular docking to elucidate CNS potential. Synthesized derivatives showed excellent binding towards the Human A2A Adenosine receptor.
2018 ◽
Vol 1163
◽
pp. 147-160
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2009 ◽
Vol 17
(1)
◽
pp. 401-410
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Keyword(s):
Keyword(s):
2021 ◽
Vol 36
(1)
◽
pp. 618-626
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Keyword(s):
Keyword(s):