scholarly journals SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW BENZTHIAZOLE OXIME ETHER DERIVATIVES

2021 ◽  
Vol 11 (6) ◽  
pp. 47-50
Author(s):  
Sachin V Patil
Keyword(s):  
Biological Activities ◽  
Alkyl Halides ◽  
Ethyl Chloride ◽  
Absolute Ethanol ◽  
Spectroscopic Methods ◽  
Butyl Chloride ◽  
Oxime Ether ◽  
Antimicrobial Evaluation ◽  
Oxime Derivatives

Some new oxime ether derivatives containing benzthiazole heterocyclic nuclei are synthesized. The reaction of 2-mercapto benzthiazole with α-halo ketones followed by reaction with hydroxylamine gave oxime derivatives which on reaction with alkyl halides viz. ethyl chloride, n-propyl chloride, and n-butyl chloride in absolute ethanol afforded the target compounds 4a-l. The structure of all the synthesized compounds was confirmed by spectroscopic methods like mass and NMR. All compounds after structural confirmation were tested for biological activities.

scholarly journals Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives

2019 ◽  
Vol 20 (9) ◽  
pp. 2184 ◽  
Author(s):  
Ahmed Dhahir Latif ◽  
Tímea Gonda ◽  
Máté Vágvölgyi ◽  
Norbert Kúsz ◽  
Ágnes Kulmány ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Gynecological Cancer ◽  
Human Leukemia ◽  
Oxime Ether ◽  
M Phase ◽  
Induced Apoptosis ◽  
Mcf 7

Naringenin is one of the most abundant dietary flavonoids exerting several beneficial biological activities. Synthetic modification of naringenin is of continuous interest. During this study our aim was to synthesize a compound library of oxime and oxime ether derivatives of naringenin, and to investigate their biological activities. Two oximes and five oxime ether derivatives were prepared; their structure has been elucidated by NMR and high-resolution mass spectroscopy. The antiproliferative activity of the prepared compounds was evaluated by MTT assay against human leukemia (HL-60) and gynecological cancer cell lines isolated from cervical (HeLa, Siha) and breast (MCF-7, MDA-MB-231) cancers. Tert-butyl oxime ether derivative exerted the most potent cell growth inhibitory activity. Moreover, cell cycle analysis suggested that this derivative caused a significant increase in the hypodiploid (subG1) phase and induced apoptosis in Hela and Siha cells, and induced cell cycle arrest at G2/M phase in MCF-7 cells. The proapoptotic potential of the selected compound was confirmed by the activation of caspase-3. Antioxidant activities of the prepared molecules were also evaluated with xanthine oxidase, DPPH and ORAC assays, and the methyl substituted oxime ether exerted the most promising activity.

Efficient synthesis and antimicrobial evaluation of 2-((1-substituted-1H-1,2,3-triazol-4-yl)-1-naphthaldehydes and their oxime derivatives

2017 ◽  
Vol 26 (7) ◽  
pp. 1469-1480 ◽  
Author(s):  
Pinki Yadav ◽  
Kashmiri Lal ◽  
Poonam Rani ◽  
Satbir Mor ◽  
Ashwani Kumar ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Antimicrobial Evaluation ◽  
Oxime Derivatives

Antimicrobial Evaluation of New Quinoxaline Derivatives Synthesized by Selective Coupling with Alkyl Halides and Amino Acids Esters

2017 ◽  
Vol 54 (5) ◽  
pp. 2881-2888 ◽  
Author(s):  
Ahmed T. A. Boraei ◽  
El Sayed H. El Tamany ◽  
Ibrahim A. I. Ali ◽  
Sara M. Gebriel
Keyword(s):  
Amino Acids ◽  
Alkyl Halides ◽  
Quinoxaline Derivatives ◽  
Antimicrobial Evaluation

scholarly journals Phytochemical Traits and Biological Activity of Eryngium amethystinum and E. alpinum (Apiaceae)

Horticulturae ◽  
2021 ◽  
Vol 7 (10) ◽  
pp. 364
Author(s):  
Dario Kremer ◽  
Marijana Zovko Končić ◽  
Ivan Kosalec ◽  
Iztok Jože Košir ◽  
Tanja Potočnik ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
High Performance ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Dilution Assay ◽  
Germacrene D ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Eryngium amethystinum L. is a wild vegetable used in Croatia. Both E. amethystinum and E. alpinum L. are decorative plants that can also be used in horticulture. To find out the hidden qualities of these two species, the following biological activities were studied: essential oil (EO) composition, analyzed by gas chromatography and gas chromatography with mass spectrometry (GC, GC–MS); phenolic compound content (PC), analyzed by high performance liquid chromatography (HPLC); total phenols as well as total flavonoids, analyzed by ultraviolet–visible spectrophotometry (UV/Vis); antioxidants, analyzed by 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity (DPPH), b-carotene-linoleic acid assay, chelating activity and reducing power of the extracts; and antimicrobial evaluation by micro-dilution assay and inhibition of Candida albicans blastospore germination. The major constituents of EO were β-caryophyllene (15.2%), α-pinene (10.2%) and 2,3,6-trimethylbenzaldehyde (9.3%) for E. amethystinum and caryophyllene oxide (27.9%), bicyclogermacrene (13.2%) and germacrene D (8.2%) for E. alpinum. The methanol extracts of both species showed a broad spectrum of antibacterial and antifungal activity with minimum inhibitory concentrations (MIC) less than or equal to 1.944 and 1.11 mg/mL, respectively.

scholarly journals Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

2020 ◽  
Vol 40 (12) ◽  
pp. 4315
Author(s):  
Yue Zhu ◽  
Dandan Zheng ◽  
Heyi Miao ◽  
Cheng Qian ◽  
Hong Dai ◽  
...  
Keyword(s):  
Biological Activities ◽  
Oxime Derivatives

scholarly journals Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Bearing an Oxazole Moiety

2020 ◽  
Vol 40 (3) ◽  
pp. 774
Author(s):  
Yue Zhu ◽  
Dandan Zheng ◽  
Yadan Ni ◽  
Jinfeng Li ◽  
Huanyu Zhou ◽  
...  
Keyword(s):  
Biological Activities ◽  
Oxime Derivatives

scholarly journals A review on biological activities of Schiff base, hydrazone, and oxime derivatives of curcumin

RSC Advances ◽  
2020 ◽  
Vol 10 (50) ◽  
pp. 30186-30202 ◽  
Author(s):  
Sakineh Omidi ◽  
Ali Kakanejadifard
Keyword(s):  
Schiff Base ◽  
Biological Activities ◽  
Oxime Derivatives ◽  
Derivatives Of

Schiff base, hydrazone, and oxime derivatives of curcumin showed enhanced biological activities.

Synthesis of some 1H-1,5-benzodiazepine Series Containing Chromene Ring from α,β-Unsaturated Ketones of 6-Acetyl-5-Hydroxy-4-Methylcoumarin

2020 ◽  
Vol 17 (5) ◽  
pp. 404-410 ◽  
Author(s):  
Duong Ngoc Toan ◽  
Nguyen Dinh Thanh ◽  
Mai Xuan Truong ◽  
Nguyen Minh Thao
Keyword(s):  
Biological Activities ◽  
Absolute Ethanol ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Unsaturated Ketones ◽  
Molar Ratios ◽  
Antibacterial And Antifungal Activities ◽  
Substituted Benzaldehydes ◽  
Antibacterial And Antifungal ◽  
Layer Chromatography

Background: Reaction of α,β-unsaturated ketones with o-phenylenediamine afforded corresponding 2,3-dihydro-1H-1,5-benzodiazepines. Objective: α,β-Unsaturated ketones of 6-acetyl-5-hydroxy-4-methylcoumarin are precursors for synthesis of 2,3-dihydro-1H-1,5-benzodiazepines by a reaction with o-phenylenediamine. Methods: Enones of 6-acetyl-5-hydroxy-4-methylcoumarin were prepared from this ketone and (un)substituted benzaldehydes in the presence of piperidine, triethylamine, or pyridine as a catalyst in absolute ethanol with 1:1 molar ratios, respectively. 2',3'-Dihydro-1H-1',5'-benzodiazepines were synthesized by using the reaction of these enones with o-phenylenediamine in absolute ethanol in the presence of glacial acetic acid as a catalyst. Their biological activities were evaluated using the disk diffusion method. Results: Seven new 2',3'-dihydro-1H-1',5'-benzodiazepines were obtained and their structures were confirmed by thin-layer chromatography, IR, NMR and MS spectra. Some synthesized benzodiazepines showed antibacterial and antifungal activities against Escherichia coli (Gram-(−) bacterium), Staphylococus epidermidis (Gram-(+) bacterium). Candida albicans (fungus). Conclusion: The formation of enones from 6-acetyl-5-hydroxy-4-methylcoumarin and (un)substituted benzaldehydes could be catalyzed by piperidine, triethylamine, pyridine to afford similar yields. 2',3'-dihydro-1H- 1',5'-benzodiazepines have been synthesized from the aforementioned enones and o-phenylenediamine.

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