scholarly journals Protective effect of sildenafil in pulmonary hypertensive child with congenital heart disease

2018 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Oxygen Saturation ◽  
Pulmonary Artery Pressure ◽  
Primary Pulmonary Hypertension ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Acceleration Time ◽  
Artery Pressure ◽  
Secondary Type

Objective Pulmonary hypertension has been described as an elevation in mean pulmonary artery pressure (PAP) >25 mmHg at rest or 30 mmHg during exercise, which can be classified into primary and secondary pulmonary hypertension.Methods In this study, subjects were divided into two groups of patients and controls. The patients were treated with Sildenafil for 3 months, starting with 0.2 mg/kg/dose, six times daily and then the dose was increased with an increment of 0.2 mg/kg/dose every 15 days. Echocardiography examination, including pulmonary artery pressure, tricuspid regurgitation velocity, and pulmonary artery acceleration time, as well as oxygen saturation (SpO2) rate were measured every 15 days.Results The results revealed that a significant decrease (P < 0.05) in the pulmonary artery and tricuspid pressure, and a significant increase (P < 0.05) in the rate of blood oxygen saturation and pulmonary artery acceleration time have been found.Conclusion The results of this study reveal that Sildenafil has a great effect in the treatment of the secondary type of pulmonary hypertension and has a negligible effect on primary pulmonary hypertension.

scholarly journals Abnormal Pulmonary Artery Pressure Response in Asymptomatic Carriers of Primary Pulmonary Hypertension Gene

Circulation ◽  
2000 ◽  
Vol 102 (10) ◽  
pp. 1145-1150 ◽  
Author(s):  
Ekkehard Grünig ◽  
Bart Janssen ◽  
Derliz Mereles ◽  
Ulrike Barth ◽  
Mathias M. Borst ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Primary Pulmonary Hypertension ◽  
Pressure Response ◽  
Asymptomatic Carriers ◽  
Artery Pressure

Pulmonary Artery Pressure–Flow Relations after Prostacyclin in Primary Pulmonary Hypertension

2002 ◽  
Vol 165 (3) ◽  
pp. 338-340 ◽  
Author(s):  
VINCENT CASTELAIN ◽  
DENIS CHEMLA ◽  
MARC HUMBERT ◽  
OLIVIER SITBON ◽  
GERALD SIMONNEAU ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Primary Pulmonary Hypertension ◽  
Pressure Flow ◽  
Artery Pressure

scholarly journals Correlation of Pulse Wave Transit Time with Pulmonary Artery Pressure in a Porcine Model of Pulmonary Hypertension

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1212
Author(s):  
Fabian Mueller-Graf ◽  
Jonas Merz ◽  
Tim Bandorf ◽  
Chiara Albus ◽  
Maike Henkel ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Transit Time ◽  
Pulse Wave ◽  
Correlation Coefficients ◽  
Physiological Basis ◽  
Artery Pressure ◽  
Hypoxic Vasoconstriction ◽  
Pulse Wave Transit Time

For the non-invasive assessment of pulmonary artery pressure (PAP), surrogates like pulse wave transit time (PWTT) have been proposed. The aim of this study was to invasively validate for which kind of PAP (systolic, mean, or diastolic) PWTT is the best surrogate parameter. To assess both PWTT and PAP in six healthy pigs, two pulmonary artery Mikro-Tip™ catheters were inserted into the pulmonary vasculature at a fixed distance: one in the pulmonary artery trunk, and a second one in a distal segment of the pulmonary artery. PAP was raised using the thromboxane A2 analogue U46619 (TXA) and by hypoxic vasoconstriction. There was a negative linear correlation between PWTT and systolic PAP (r = 0.742), mean PAP (r = 0.712) and diastolic PAP (r = 0.609) under TXA. During hypoxic vasoconstriction, the correlation coefficients for systolic, mean, and diastolic PAP were consistently higher than for TXA-induced pulmonary hypertension (r = 0.809, 0.778 and 0.734, respectively). Estimation of sPAP, mPAP, and dPAP using PWTT is feasible, nevertheless slightly better correlation coefficients were detected for sPAP compared to dPAP. In this study we establish the physiological basis for future methods to obtain PAP by non-invasively measured PWTT.

scholarly journals The Relationship between Vitamin D Deficiency and Pulmonary Hypertension

2013 ◽  
Vol 114 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Mehmet Demir ◽  
U. Uyan ◽  
S. Keçeoçlu ◽  
C. Demir
Keyword(s):  
Vitamin D ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Vitamin D Deficiency ◽  
Pulmonary Artery Pressure ◽  
Control Group ◽  
Systolic Pulmonary Artery Pressure ◽  
Control Groups ◽  
Artery Pressure ◽  
Vitamin D Levels

Vitamin D deficiency actives renin-angiotensin-aldosterone system (RAAS) which affects cardiovascular system. Activation of RAAS is associated with pulmonary hypertension (PHT). Relation between vitamin D deficiency and PHT could be therefore suggested. In  our study we compared pulmonary artery pressure between vitamin D deficiency and control groups. 115 consecutive patients (average age: 61.86 ± 5.86) who have detected very low vitamin D (vitamin D levels < 10 ng/ml) were enrolled. 117 age matched persons (average age: 61.74 ± 5.99) were selected as the control group. All groups underwent transthoracic echocardiography. Routine biochemical measurement of 25-OH vitamin D and parathormon (PTH) levels were performed. Baseline characteristics of the study groups were comparable. Systolic pulmonary artery pressure (SPAP) of patients in  the low vitamin D group was higher than the control groups. As a  result our study, a  relation between vitamin D deficiency and pulmonary artery hypertension was revealed.

Sign in / Sign up

Export Citation Format

Share Document