The next-to-leading order electro-weak radiative corrections to the µ±e- → µ±e- process are reviewed and their relevance is discussed for the MUonE experiment, proposed at CERN. The aim of MUonE is the high precision measurement of the QED running coupling constant in the space-like region, from which the full hadronic contribution can be extracted and used to provide a new and independent determination of the leading-order hadronic correction to the muon g − 2. In this context, the required accuracy demands that radiative corrections are accounted for at the highest level of precision and implemented into a Monte Carlo event generator for data analysis. The first step towards the final goal of theoretical precision, which will require the full set of NNLO corrections and resummation of higher orders, is the inclusion of NLO electro-weak corrections.