ADME Evaluation (K11054) of Sulfolane (126-33-0) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection, or Dermal Application

Rats have an attenuated or absent febrile response to exogenous pyrogen (e.g., bacterial endotoxin) near term of pregnancy. With the aim of providing insight into possible mechanism(s) of the altered febrile response to exogenous pyrogen, experiments have been carried out on 67 time-bred Sprague-Dawley rats to investigate the febrile response to endogenous pyrogen [i.e., interleukin-1 beta (IL-1 beta)]. On day 13 of gestation, intravenous injection of IL-1 beta produced a significant increase in body temperature with a latency of approximately 30 min and a duration of approximately 120 min. In contrast, on days 17 and 21 of gestation as well as on the day of delivery, intravenous injection of IL-1 beta produced significant decreases in body temperature. Thus rats do not develop fever in response to endogenous pyrogen near term of pregnancy but rather become hypothermic. The mechanism of the altered body temperature response to exogenous pyrogen as pregnancy proceeds remains unknown. We speculate, however, that it most likely lies downstream from the formation of endogenous pyrogen.

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Teratogenicity study of N-methylpyrrolidone after dermal application to Sprague-Dawley rats

Fundamental and Applied Toxicology ◽

10.1016/s0272-0590(82)80117-6 ◽

1982 ◽

Vol 2 (2) ◽

pp. 73-76 ◽

Cited By ~ 45

Author(s):

P BECCI ◽

M KNICKERBOCKER ◽

E REAGAN ◽

R PARENT ◽

L BURNETTE

Keyword(s):

Sprague Dawley ◽

Sprague Dawley Rats ◽

Dermal Application

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Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide.

Journal of Experimental Medicine ◽

10.1084/jem.165.6.1688 ◽

1987 ◽

Vol 165 (6) ◽

pp. 1688-1702 ◽

Cited By ~ 30

Author(s):

S A Stimpson ◽

R E Esser ◽

P B Carter ◽

R B Sartor ◽

W J Cromartie ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Intravenous Injection ◽

Lipid A ◽

Disease Process ◽

Polymyxin B ◽

Sprague Dawley ◽

E Coli ◽

Sprague Dawley Rats ◽

Ankle Joints ◽

Group A

Rat ankle joints injected intraarticularly with 5 micrograms of group A streptococcal peptidoglycan-polysaccharide (PG-APS) developed an acute course of arthritis. Recurrence of arthritis was induced in 100% of these joints by intravenous injection of as little as 10 micrograms of Salmonella typhimurium lipopolysaccharide (LPS) 3 wk after intraarticular injection. This reaction was similar in athymic and euthymic rats. Buffalo rats were less susceptible than Lewis or Sprague-Dawley rats. Neisseria gonorrhoeae, Yersinia enterocolitica, and Escherichia coli LPS, and S. typhimurium Re mutant LPS, were also active. Re mutant LPS activity was greatly reduced by mixing with polymyxin B. E. coli lipid A was weakly active. An acute synovitis of much less incidence, severity, and duration was seen in contralateral joints injected initially with saline, and in ankle joints of naive, previously uninjected rats after intravenous LPS injection. The intravenous injection of the muramidase mutanolysin on day 0 or 7 after intraarticular PG-APS injection prevented LPS-induced recurrence of arthritis. These studies suggest that the phlogistic activities of lipid A and peptidoglycan might interact in an inflammatory disease process, and that LPS may play a role in recurrent episodes of rheumatoid arthritis or reactive arthritis.

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Disposition and Metabolism of 2,2’-Dimorpholinodiethyl Ether in Harlan Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application

Chemical Effects in Biological Systems (CEBS) ◽

10.22427/ntp-data-002-02085-0009-0000-6 ◽

2019 ◽

Author(s):

Keyword(s):

Intravenous Administration ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Dermal Application

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ADME/TK Evaluation (K10482) of N-Butylbenzenesulfonamide (3622-84-2) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection

Chemical Effects in Biological Systems (CEBS) ◽

10.22427/ntp-data-002-03240-0010-0000-2 ◽

2019 ◽

Author(s):

Keyword(s):

Intravenous Injection ◽

Sprague Dawley ◽

Sprague Dawley Rats

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Intravenous Administration of Multiwalled Carbon Nanotubes Aggravates High-Fat Diet-Induced Nonalcoholic Steatohepatitis in Sprague Dawley Rats

International Journal of Toxicology ◽

10.1177/1091581816653363 ◽

2016 ◽

Vol 35 (6) ◽

pp. 634-643 ◽

Cited By ~ 1

Author(s):

Yu-Ying Xu ◽

Juan Ge ◽

Mo-Han Zhang ◽

Wen-Jie Sun ◽

Jun Zhang ◽

...

Keyword(s):

Carbon Nanotubes ◽

Fatty Liver ◽

Multiwalled Carbon Nanotubes ◽

Intravenous Injection ◽

Intravenous Administration ◽

Nonalcoholic Steatohepatitis ◽

Sprague Dawley ◽

Multiwalled Carbon ◽

Liver Model ◽

Sprague Dawley Rats

Multiwalled carbon nanotubes (MWCNTs) have been explored in pharmaceutical applications such as tumor targeting and delivery of drugs, in which MWCNTs are given through intravenous injection. However, the biosafety of MWCNTs is of concern for such application. Therefore, in the current study, we used a fatty liver model to investigate the possible toxicity of MWCNTs to the liver, as MWCNTs were retained mainly in the liver of mice after intravenous injection. Male Sprague Dawley rats were used to generate the fatty liver model, and the effects of intravenous administration of MWCNTs on fatty liver were studied. Hematoxylin and eosin staining for hepatocellular anatomy and Masson trichrome staining for hepatic fibrosis were conducted. Histologically, MWCNTs aggravated steatohepatitis with higher nonalcoholic fatty liver disease scores. Analysis of liver injury markers indicated that MWCNTs administration resulted in chronic hepatitis, along with increased liver fat and altered liver oxidation, including the increase of P6 protein and the depletion of glutathione. In conclusion, our results suggest that MWCNTs can aggravate nonalcoholic steatohepatitis in Sprague Dawley rats, and oxidative injury may be involved in this process.

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