scholarly journals SARS CoV-2 adenovirus and RNA based vaccines potential autoimmune complications: could we lower the chances?

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
High Risk ◽  
Hospital Admissions ◽  
Risk Groups ◽  
Spike Protein ◽  
Subunit Vaccines ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Vaccination Campaigns ◽  
Personalized Risk

Nucleic acid based - mRNA based and adenovirus vectored - vaccines, were first ever or first commercially ever approved for the public, respectively. However, these newly emergency approved types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia, myocarditis and immune induced thrombosis and thromboembolism that might be fatal and could reason for some of the post vaccination sudden death reports. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients as well as they might share in development of some lethal SARS CoV-2 variants. Importantly, we suggest that SARS CoV-2 mass vaccination campaigns were the worst ever decision made and that making these COVID-19 vaccines compulsory or administering them to children or pregnant participants might be considered as a crime against humanity to the extent that no prior companies- governmental agreements would ever secure impunity. Finally, a full informed personalized risk benefit ratio especially for some described high-risk groups must be secured while suggesting that the subunit vaccines are the least hazardous ones.

scholarly journals Autoimmunity and Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination: A Global Human Right to Know then Decide.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Hospital Admissions ◽  
Risk Groups ◽  
Right To Know ◽  
Human Right ◽  
Subunit Vaccines ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Vaccination Campaigns ◽  
Personalized Risk

Nucleic acid based - mRNA based and adenovirus vectored - vaccines, were first ever or first commercially ever approved for the public, respectively. However, these newly emergency approved types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia, myocarditis and immune induced thrombosis and thromboembolism that might be fatal and could reason for some of the post vaccination sudden death reports. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients as well as they might share in development of some lethal SARS CoV-2 variants. Importantly, we suggest that SARS CoV-2 mass vaccination campaigns were the worst ever decision made and that making these COVID-19 vaccines compulsory or administering them to children or pregnant participants might be considered as a crime against humanity to the extent that no prior companies- governmental agreements would ever secure impunity. Finally, a full informed personalized risk benefit ratio especially for some described high-risk groups must be secured while suggesting that the subunit vaccines are the least hazardous ones.

scholarly journals Autoimmunity and Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination: A Global Human Right to Know then Decide.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Hospital Admissions ◽  
Risk Groups ◽  
Spike Protein ◽  
Right To Know ◽  
Human Right ◽  
Autoimmune Myocarditis ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmune myocarditis and immune induced thrombosis and thromboembolism. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Furthermore, SARS CoV-2 vaccines might share in development of some lethal SARS CoV-2 variants. Finally, we suggest that making these COVID-19 vaccines compulsory or administering them to children or pregnant participants might be considered as a crime against humanity and an informed personalized risk benefit ratio especially for described high risk groups must be secured.

scholarly journals Autoimmunity and Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination: A Global Human Right to Know then Decide.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Hospital Admissions ◽  
Risk Groups ◽  
Spike Protein ◽  
Right To Know ◽  
Human Right ◽  
Autoimmune Myocarditis ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmune myocarditis and immune induced thrombosis and thromboembolism. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Furthermore, SARS CoV-2 vaccines might share in development of some lethal SARS CoV-2 variants. Finally, we suggest that making these COVID-19 vaccines compulsory or administering them to children or pregnant participants might be considered as a crime against humanity and an informed personalized risk benefit ratio especially for described high risk groups must be secured.

scholarly journals Autoimmunity and Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination: A Global Human Right to Know then Decide.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Hospital Admissions ◽  
Risk Groups ◽  
Spike Protein ◽  
Right To Know ◽  
Human Right ◽  
Autoimmune Myocarditis ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmune myocarditis and immune induced thrombosis and thromboembolism. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Furthermore, SARS CoV-2 vaccines might share in development of some lethal SARS CoV-2 variants. Finally, we suggest that making these COVID-19 vaccines compulsory or administering them to children or pregnant participants might be considered as a crime against humanity and an informed personalized risk benefit ratio especially for described high risk groups must be secured.

scholarly journals Autoimmunity and Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination: A Global Human Right to Know then Decide.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Hospital Admissions ◽  
Risk Groups ◽  
Spike Protein ◽  
Right To Know ◽  
Human Right ◽  
Autoimmune Myocarditis ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmune myocarditis and immune induced thrombosis and thromboembolism. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Furthermore, SARS CoV-2 vaccines might share in development of some lethal SARS CoV-2 variants. Finally, we suggest that making these COVID-19 vaccines compulsory is a crime against humanity and an informed personalized risk benefit ratio especially for described high risk groups must be secured.

scholarly journals Potential Autoimmunity of SARS CoV-2 Nucleic Acid-based Vaccination: What Should We Know?

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Nucleic Acid ◽  
The Other ◽  
Spike Protein ◽  
Vulnerable Groups ◽  
Right To Know ◽  
Benefit Ratio ◽  
The Public ◽  
To Receive ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases more possibly in the short yet potentially the long term as well. On the other hand, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, including the conventional ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement. Thus, a moral, legal, and constitutional public right to know and decide basing on a personalized risk benefit ratio must be secured. In this manuscript, we analyze the theoretical autoimmunity potential of SARS CoV-2 adenovirus vectored vaccines, after we have previously discussed the same potential for mRNA-based ones. Further, we explore the vulnerable groups of vaccines recipients who are generally more liable to develop autoimmune diseases and how might these groups modify the risk if decided to receive the vaccines.

scholarly journals Potential Autoimmunity or Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination or Convalescent Plasma: A Potential Man-Made Hades.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Nucleic Acid ◽  
Autoimmune Diseases ◽  
Vulnerable Groups ◽  
Right To Know ◽  
Post Vaccination ◽  
Benefit Ratio ◽  
The Public ◽  
To Receive ◽  
A Company ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases that might also reason for some of the post vaccination sudden death reports. On the other hand, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Moreover, we explore the vulnerable groups of vaccines recipients to develop autoimmune diseases and how might these groups modify their risk if decided to receive the vaccines. Importantly, we recommend CDC to change its neutral recommendation and to advice against administration of nucleic acid-based vaccines to persons complaining from autoimmune diseases. Furthermore, we urge the FDA to consider a reevaluation of the emergency approval granted to Pfizer-BioNTech SARS CoV-2 mRNA as a company specific extra risk might be present. Finally, a moral, legal, and constitutional public right to know and decide basing on a personalized risk benefit ratio must be secured. We truly wish that science proves us wrong, as if not we suggest that the rapid race to develop and approve SARS CoV-2 vaccines with all its political and economic aspects might eventually end with a man-made Hades that might exceed COVID-19 in its dangers.

scholarly journals Potential Autoimmunity or Antibody Dependent COVID-19 Enhancement of SARS CoV-2 Vaccination or Convalescent Plasma: A Moral, Legal and Constitutional Right to Know.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
The Other ◽  
Spike Protein ◽  
Vulnerable Groups ◽  
Right To Know ◽  
Benefit Ratio ◽  
The Public ◽  
Constitutional Right ◽  
To Receive ◽  
Personalized Risk

mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases more possibly in the short yet potentially the long term as well. On the other hand, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients. Thus, a moral, legal, and constitutional public right to know and decide basing on a personalized risk benefit ratio must be secured. In this manuscript, we analyze the theoretical autoimmunity potential of SARS CoV-2 adenovirus vectored vaccines, after we have previously discussed the same potential for mRNA-based ones. Further, we explore the vulnerable groups of vaccines recipients who are generally more liable to develop autoimmune diseases and how might these groups modify the risk if decided to receive the vaccines.

scholarly journals The Efficacy of Bamlanivimab in Reducing Emergency Department Visits and Hospitalizations in a Real-World Setting

2021 ◽  
Author(s):  
Douglas S Corwin ◽  
Peter T Ender ◽  
Nitasa Sahu ◽  
Ryan A Durgham ◽  
Dennis M McGorry ◽  
...  
Keyword(s):  
Emergency Department ◽  
Monoclonal Antibody ◽  
High Risk ◽  
Real World ◽  
Hospital Admissions ◽  
Emergency Department Visits ◽  
Spike Protein ◽  
Ambulatory Treatment ◽  
Real World Setting ◽  
Antibody Targeting

Abstract Bamlanivimab, a monoclonal antibody targeting the spike protein of SARS-CoV-2, is available for ambulatory treatment of COVID-19. This real-world study confirms the efficacy of bamlanivimab in reducing hospital admissions and emergency department visits among high-risk outpatients with mild to moderate COVID-19 illness and reveals a trend toward improved mortality.

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

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