Postmastectomy radiotherapy and locoregional recurrence rate in high-risk breast cancer patients

BACKGROUND: Postmastectomy radiotherapy has been the topic for many debates over several years about its role on locoregional control as well as overall survival in premenopausal and postmenopausal breast cancer patients. METHODS: From 1994 till 1999, 233 patients underwent modified radical mastectomy for breast cancer. Among them there was 92 premenopausal patients (median age was 44 years) and 141 postmenopausal patients (median age was 60 years). Traditional prognostic factors were used to assess risk of locoregional recurrence: 84 patients were node-negative, 71 patients had 1 to 3 lymph nodes positive, and 71 patients had 4 and more positive lymph nodes; 103 patients had tumor less than 3 cm diameter and 130 patients had tumors grater than 3 cm. According to this, postmastectomy radio- therapy was applied in 125 patients of whom 117 patients (94%) had also adjuvant systemic therapy (chemotherapy and/or hormonal therapy). RESULTS: The locoregional recurrence was observed in 42 patients while 191 patients were free of (median follow-up time was 49 months). Locoregional recurrence developed in 10 patients who had postmastectomy radiotherapy and in 32 patients who did not had postmastectomy radiotherapy (p=0.0001). In the group of patients with locoregional recurrence event 5-year overall survival was 28% while 70% in the group of patients free of (p=0.00001). There was statistically significant advantage for post- mastectomy radiotherapy in the group of patients with 1 to 3 positive lymph nodes as well as for 4 and more positive lymph nodes group (p=0.0008). In addition there was statistically significant difference among postmastectomy radiotherapy group and no postmastectomy radiotherapy group for disease free survival (74% vs. 50%, 5-year disease free survival, p=0.0001) and overall survival (71% vs. 53%, 5-year overall survival, p=0.0422). CONCLUSION: Postmastectomy radiotherapy reduces locoregional recurrence rate and improves overall survival in premenopausal and postmenopausal breast cancer patients with tumors grater than 3cm diameter and positive axillary lymph nodes.

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5128 POSTER Postmastectomy Radiotherapy Reduces Locoregional Recurrence and Overall Mortality for Breast Cancer Patients With T1-2 and One to Three Positive Lymph Nodes

European Journal of Cancer ◽

10.1016/s0959-8049(11)71570-2 ◽

2011 ◽

Vol 47 ◽

pp. S368

Author(s):

K.M. Rau ◽

Y.L. Su ◽

S.H. Li ◽

H.C. Chen ◽

Y. Tang ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Cancer Patients ◽

Locoregional Recurrence ◽

Breast Cancer Patients ◽

Postmastectomy Radiotherapy ◽

Positive Lymph Nodes ◽

Overall Mortality

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Postmastectomy Radiotherapy Improves Disease-Free Survival of High Risk of Locoregional Recurrence Breast Cancer Patients with T1-2 and 1 to 3 Positive Nodes

PLoS ONE ◽

10.1371/journal.pone.0119105 ◽

2015 ◽

Vol 10 (3) ◽

pp. e0119105 ◽

Cited By ~ 14

Author(s):

Zhen-Yu He ◽

San-Gang Wu ◽

Juan Zhou ◽

Fang-Yan Li ◽

Qin Lin ◽

...

Keyword(s):

Breast Cancer ◽

High Risk ◽

Cancer Patients ◽

Locoregional Recurrence ◽

Disease Free Survival ◽

Breast Cancer Patients ◽

Postmastectomy Radiotherapy ◽

Free Survival ◽

Disease Free

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Postmastectomy Radiotherapy in T1–2 Female Breast Cancer Patients with 1–3 Positive Axillary Lymph Nodes: A Propensity Score Matched SEER Analysis

10.21203/rs.3.rs-970789/v1 ◽

2021 ◽

Author(s):

Gang Xu ◽

Shanshan Bu ◽

Xiushen Wang ◽

Hong Ge

Keyword(s):

Breast Cancer ◽

Propensity Score ◽

Lymph Nodes ◽

Cancer Patients ◽

Female Breast Cancer ◽

Axillary Lymph ◽

Breast Cancer Patients ◽

Postmastectomy Radiotherapy ◽

Female Breast ◽

Positive Lymph Nodes

Abstract Purpose The application of postmastectomy radiotherapy (PMRT) in T1–2 female breast cancer patients with 1–3 positive lymph nodes has been controversial. We sought to determine the survival benefits of PMRT in the patients with T1–2 and 1–3 positive nodes. Methods A retrospective study using the Surveillance, Epidemiology, and End Results (SEER) Regs Custom Data (with additional treatment fields) from 2001 to 2011 was performed. Patients who received PMRT were matched by the propensity score with patients who did not receive PMRT. The Overall survival (OS) and breast cancer-specific survival (BCSS) were analyzed. Results We identified 56,725 female breast cancer patients with T1–2 and 1–3 positive nodes, and 18,646 patients were included in the analysis. After propensity score matching (1:1), with a median follow-up of 116 months, PMRT showed an increase in the OS (P = 0.018) but had no effect on the BCSS. The 10-year OS rates were 76.8% and 74.4%, and the 10-year BCSS rates were 82.8% and 82.2% for the patients who received and who did not receive PMRT, respectively. Only patients with 3 positive nodes could gain the benefit of PMRT for BCSS. Conclusion PMRT for patients with T1–2 and 1–3 positive lymph nodes could increase the 10-year OS, and had no effect on the 10-year BCSS. Subgroup analysis indicated that only patients with 3 positive lymph nodes could benefit from PMRT for both the OS and BCSS.

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Risk factors for locoregional recurrence after postmastectomy radiotherapy in breast cancer patients with four or more positive axillary lymph nodes

Current Oncology ◽

10.3747/co.21.2000 ◽

2014 ◽

Vol 21 (5) ◽

pp. 685 ◽

Cited By ~ 6

Author(s):

Q. Li ◽

S. Wu ◽

J. Zhou ◽

J. Sun ◽

F. Li ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Lymph Nodes ◽

Cancer Patients ◽

Locoregional Recurrence ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Breast Cancer Patients ◽

Postmastectomy Radiotherapy

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Postmastectomy Radiotherapy in T1–2 Women Breast Cancer Patients with 1–3 Positive Axillary Lymph Nodes: A Propensity Score Matched SEER Analysis

10.21203/rs.3.rs-121109/v1 ◽

2020 ◽

Author(s):

Gang Xu ◽

Shanshan Bu ◽

Xiushen Wang ◽

Hong Ge

Keyword(s):

Breast Cancer ◽

Propensity Score ◽

Lymph Nodes ◽

Cancer Patients ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Breast Cancer Patients ◽

Cancer Specific Survival ◽

Postmastectomy Radiotherapy ◽

Positive Lymph Nodes

Abstract Purpose: The application of postmastectomy radiotherapy (PMRT) in T1–2 women breast cancer patients with 1–3 positive lymph nodes has been controversial. We sought to determine the survival benefits of PMRT in the patients with T1–2 and 1–3 positive nodes.Methods: A retrospective study using the Surveillance, Epidemiology, and End Results (SEER) Regs Custom Data (with additional treatment fields) from 2001 to 2011 was performed. Patients who received PMRT were matched by the propensity score with patients who did not receive PMRT. The Overall survival (OS) and breast cancer-specific survival (BCSS) were analyzed. Results: We identified 56,725 women breast cancer patients with T1–2 and 1–3 positive nodes, and 18,646 patients were included in the analysis. After propensity score matching (1:1), with a median follow-up of 116 months, PMRT showed an increase in the OS (P = 0.018) but had no effect on the BCSS. The 10-year OS rates were 76.8% and 74.4%, and the 10-year BCSS rates were 82.8% and 82.2% for the patients who received and who did not receive PMRT, respectively. Only patients with 3 positive nodes could gain the benefit of PMRT for BCSS.Conclusion: PMRT for patients with T1–2 and 1–3 positive lymph nodes could increase the 10-year OS, and had no effect on the 10-year BCSS. Subgroup analysis indicated that only patients with 3 positive lymph nodes could benefit from PMRT for both the OS and BCSS.

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