Synthesis, characterization and antibacterial and antifungal studies of some tetraazamacrocyclic complexes

A new series of complexes was synthesized by template condensation of malonyl dihydrazide and glyoxal in methanolic medium in the presence of divalent cobalt, nickel, copper, zinc and cadmium salts, whereby complexes of the type: [M(C5H6N4O2)X2] where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), and X = Cl-, NO3- and OAc-, were formed. The complexes were characterized with the aid of elemental analyses, conductance measurements, magnetic susceptibility measurements, and electronic, NMR and infrared spectral studies. Based on these studies, a six coordinate octahedral geometry is proposed for these complexes. The complexes were tested for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration shown by complexes was compared with that of standard drugs.

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Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids

Journal of Chemistry ◽

10.1155/2013/727182 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

C. Mallikarjunaswamy ◽

D. G. Bhadregowda ◽

L. Mallesha

Keyword(s):

Antimicrobial Activity ◽

The Other ◽

Spectral Studies ◽

H Nmr ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Ft Ir ◽

Uv Visible ◽

Antibacterial And Antifungal

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.

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Synthesis,Characterization and Evaluation of the Anticancer and Antimicrobial Activities of Some Novel Benzazole and Benzazine Derivatives

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v3i3.927 ◽

2007 ◽

Vol 3 (3) ◽

pp. 252-263

Author(s):

Wesam Saber Shehab ◽

Naglaa Z.H. Eleiwa ◽

Samar.M. Mouneir

Keyword(s):

Cancer Cells ◽

Benzimidazole Derivative ◽

Coupling Reaction ◽

Antimicrobial Activities ◽

Spectral Studies ◽

Design Modification ◽

Future Design ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

The present study was designed to synthesize and develop new useful lead compounds (some novel benzazole and benzazine derivatives ) of simple structure , exhibiting optimal in vitro anticancer and antimicrobial potency. Phenylenediamine derivative 1 was condensed with dithiocarboxylic acid derivatives 2 and produced benzimidazole derivative 4. The benzotriazepines 8 and 10 were formed by the reaction of 1 with dicarbonyl derivatives followed by intermolecular coupling reaction. The synthesis of benzotriazine12, benzotriazole 14,17, benzimidazole16 and benzothiadiazine 19 from compound 1 was also described. The Synthesized Compounds were characterized by Spectral Studies like IR, H1 – NMR and Analysis Spectra .The title compounds were screened for their possible In vitro anticancer and antimicrobial activities. Among the synthesized compounds, some have shown promisingly remarkable activities against different cancer cell lines (MCF-7 human breast cancer cells, HepG2 human hepatocarcinoma cells and PC3 human prostate cancer cells)and moderate to high antibacterial and antifungal activities. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs.

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Infrared, 1H-NMR Spectral Studies of some Methyl 6-O-Myristoyl-α-D-Glucopyranoside Derivatives: Assessment of Antimicrobial Effects

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.58.122 ◽

2015 ◽

Vol 58 ◽

pp. 122-136 ◽

Cited By ~ 4

Author(s):

Sarkar M.A. Kawsar ◽

Khaleda Mymona ◽

Refat Asma ◽

Mohammad A. Manchur ◽

Yasuhiro Koide ◽

...

Keyword(s):

Pathogenic Fungi ◽

Spectral Studies ◽

Bacterial Strains ◽

Substitution Product ◽

Antifungal Activities ◽

H Nmr ◽

Antibacterial And Antifungal Activities ◽

Fungal Phytopathogens ◽

Antibacterial And Antifungal

This study was carried out to regioselective myristoylation of methyl α-D-glucopyranoside (1) using the direct acylation method gave the corresponding methyl 6-O-myristoyl-α-D-glucopyranoside (2) in fair yield. A number of 2,3,4-tri-O-acyl derivatives (3-15) of this 6-O-substitution product using a wide variety of acylating agents were also prepared in order to obtain newer derivatives of synthetic and biological importance. The reaction conditions are reasonably simple and yields were very good. The structures of the title compounds (2-15) were established by using analytical, physicochemical techniques and spectroscopic data (IR and 1H-NMR). All the synthesized compounds were employed as test chemicals for in vitro antimicrobial functionality test against Gram-positive Bacillus subtilis, Staphylococcus aureus, Gram-negative Escherichia coli, Pseudomonas aeruginosa bacteria and plant pathogenic fungi Aspergillus niger and Candida albicans. For comparative studies, antimicrobial activity of standard antibiotics, Ampicillin and Nystatin were also carried out against these microorganisms. The study revealed that the tested samples exhibited moderate to good antibacterial and antifungal activities. It was also observed that the test substances were more effective against fungal phytopathogens than those of the human bacterial strains. Encouragingly, a number of tested chemicals showed nearest antibacterial and antifungal activities with the standard antibiotics employed.

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Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones

International Scholarly Research Notices ◽

10.1155/2014/439243 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Namratha Bhandari ◽

Santosh L. Gaonkar

Keyword(s):

Convenient Method ◽

Nmr Spectra ◽

Spectral Studies ◽

Antimicrobial Screening ◽

Antifungal Activities ◽

H Nmr ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Antibacterial And Antifungal ◽

C Nmr

The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1H NMR, 13C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by 1H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral studies, formation of 2-amino-1,3,4-thiadiazoles from the isobenzofuran acyl thiosemicarbazides 11(a–h) is ruled out.

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Synthesis and characterization of divalent metal complexes with ligand derived from the reaction of 3-aminopyridine and biacetyl

Journal of the Serbian Chemical Society ◽

10.2298/jsc0609939s ◽

2006 ◽

Vol 71 (8-9) ◽

pp. 939-944 ◽

Cited By ~ 2

Author(s):

D.P. Singh ◽

Ramesh Kumar ◽

Rimpi Mehani ◽

S.K. Verma

Keyword(s):

Far Infrared ◽

Azomethine Nitrogen ◽

Spectral Studies ◽

Copper Salts ◽

Cobalt Nickel ◽

Pyridine Nitrogen ◽

Distorted Octahedral ◽

Infrared Spectral ◽

Divalent Cobalt

Divalent cobalt, nickel and copper salts reacted in situ with 3-aminopyridine and biacetyl to form complexes of the type: [M(Ap2biac) 2X2], where Ap 2biac is the ligand and X=Cl, Br, NO3 or NCS. The complexes were analyzed and characterized as distorted octahedral by conductance, molecular weight magnetic, electronic and IR spectral studies. The electronic spectra were interpreted and tentative assignments made. The infrared spectral studies revealed that two molecules of 3-aminopyridine were joined by molecules of biacetyl through a two carbon atom bridge and that the ligand coordinated through azomethine nitrogen atoms, whereas the pyridine nitrogen does not participate in the coordination. In the far infrared spectra, various metal-ligand vibrations were observed and are discussed.

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Synthetic, Structural, and Biochemical Studies of Organotin(IV) with Schiff Bases Having Nitrogen and Sulphur Donor Ligands

Bioinorganic Chemistry and Applications ◽

10.1155/bca/2006/23245 ◽

2006 ◽

Vol 2006 ◽

pp. 1-7 ◽

Cited By ~ 45

Author(s):

Har Lal Singh ◽

A. K. Varshney

Keyword(s):

Magnetic Resonance ◽

Schiff Bases ◽

Donor Ligands ◽

Spectral Studies ◽

Molecular Weights ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Biochemical Studies ◽

Antibacterial And Antifungal ◽

Heterocyclic Aldehydes

Three bidentate Schiff bases having nitrogen and sulphur donor sequences were prepared by condensing S-benzyldithiocarbazate (NH2NHCS2CH2C6H5) with heterocyclic aldehydes. The reaction of diphenyltin dichloride with Schiff bases leads to the formation of a new series of organotin(IV) complexes. An attempt has been made to prove their structures on the basis of elemental analyses, conductance measurements, molecular weights determinations, UV, infrared, and multinuclear magnetic resonance (H1,C13, andS119n) spectral studies. Organotin(IV) complexes were five- and six-coordinate. Schiff bases and their corresponding organotin complexes have also been screened for their antibacterial and antifungal activities and found to be quite active in this respect.

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Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

10.31221/osf.io/g7mx8 ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Nalidixic Acid ◽

Copper Complexes ◽

Biological Activities ◽

Bidentate Coordination ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Oxadiazole Derivatives ◽

Antibacterial And Antifungal ◽

Derivatives Of ◽

Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

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Substituted 4-Formyl-2H-chromen-2-ones: Their Reaction with N-(2,3,4,6-Tetra-Oacetyl- β-D-galactopyranosyl)thiosemicarbazide, Antibacterial and Antifungal Activity of Their Thiosemicarbazone Products

Current Organic Chemistry ◽

10.2174/1385272824999200812132256 ◽

2020 ◽

Vol 24 (19) ◽

pp. 2272-2282

Author(s):

Vu Ngoc Toan ◽

Nguyen Minh Tri ◽

Nguyen Dinh Thanh

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Candida Albicans ◽

Selenium Dioxide ◽

Antibacterial And Antifungal Activity ◽

E Coli ◽

Antibacterial And Antifungal Activities ◽

Alkyl Ethers ◽

Antibacterial And Antifungal

Several 6- and 7-alkoxy-2-oxo-2H-chromene-4-carbaldehydes were prepared from corresponding alkyl ethers of 6- and 7-hydroxy-4-methyl-2-oxo-2H-chromen-2-ones by oxidation using selenium dioxide. 6- and 7-Alkoxy-4-methyl-2H-chromenes were obtained with yields of 57-85%. Corresponding 4-carbaldehyde derivatives were prepared with yields of 41-67%. Thiosemicarbazones of these aldehydes with D-galactose moiety were synthesized by reaction of these aldehydes with N-(2,3,4,6-tetra-O-acetyl-β-Dgalactopyranosyl) thiosemicarbazide with yields of 62-74%. These thiosemicarbazones were screened for their antibacterial and antifungal activities in vitro against bacteria, such as Staphylococcus aureus, Escherichia coli, and fungi, such as Aspergillus niger, Candida albicans. Several compounds exhibited strong inhibitory activity with MIC values of 0.78- 1.56 μM, including 8a (against S. aureus, E. coli, and C. albicans), 8d (against E. coli and A. niger), 9a (against S. aureus), and 9c (against S. aureus and C. albicans).

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Synthesis, Characterization, and Antimicrobial Activity of Methyl-2-aminopyridine-4-carboxylate Derivatives

Journal of Chemistry ◽

10.1155/2013/312961 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

S. Nagashree ◽

P. Mallu ◽

L. Mallesha ◽

S. Bindya

Keyword(s):

Antimicrobial Activity ◽

Spectral Studies ◽

H Nmr ◽

Chemical Structures ◽

Elemental Analyses ◽

Ft Ir

A series of methyl-2-aminopyridine-4-carboxylate derivatives,3a–f,were synthesized in order to determine theirin vitroantimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, FT-IR, and1H NMR spectral studies. Among the synthesized compounds,3cand3dshowed good antimicrobial activity compared to other compounds in the series.

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