scholarly journals One-pot green synthesis of isoxazol-5(4H)-one derivatives by Dowex1-x8OH in water

2016 ◽  
Vol 81 (9) ◽  
pp. 971-978 ◽  
Author(s):  
Davood Setamdideh
Keyword(s):  
Green Synthesis ◽  
Reaction Times ◽  
One Pot ◽  
The One ◽  
High Yields ◽  
Operational Simplicity

4-arylmethylidene-3-methylisoxazol-5(4H)-ones and 4-arylmethyl-idene-3-phenylisoxazol-5(4H)-ones have been synthesized in the one-pot three-component synthesis in the presence of Dowex1-x8OH as catalyst in water. The products have been obtained in high yields (90-95%) and proper reaction times (1-5 hours). This method has eco-friendly profile and operational simplicity.

Microwave-Assisted and L-proline Catalysed Domino Cyclisation in an Aqueous Medium: A Rapid, Highly Efficient and Green Synthesis of Benzo[a]Phenazine Annulated Heterocycles

2016 ◽  
Vol 40 (12) ◽  
pp. 722-726 ◽  
Author(s):  
Afshin Yazdani-Elah-Abadi ◽  
Razieh Mohebat ◽  
Mehrnoosh Kangani
Keyword(s):  
Green Synthesis ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Heterocyclic Ring ◽  
One Pot ◽  
Microwave Assisted ◽  
Highly Efficient ◽  
High Yields ◽  
Work Up ◽  
Operational Simplicity

A highly efficient one-pot, two-step microwave-assisted procedure was applied for the rapid and green synthesis of benzo[a]phenazine annulated heterocyclic ring systems from the three- or four-component condensation reactions of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aromatic aldehydes and 1,3-indandione using L-proline as a bifunctional organocatalyst in water. This new procedure has a number of advantages such as high yields, very short reaction times, operational simplicity, simple work-up procedures and avoidance of hazardous or toxic catalysts and organic solvents. Moreover, the catalyst can be recovered and reused several times without much loss of its performance.

One-pot synthesis of 1-(benzothiazolylamino)aryl methyl-2-naphthols and 3-benzothiazolyl 2,3-dihydroquinazolinones using a magnetically recoverable core–shell nanocomposite as catalyst

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yousef Mardani ◽  
Zahed Karimi-Jaberi ◽  
Mohammad Jaafar Soltanian Fard
Keyword(s):  
Reaction Times ◽  
Chemical Waste ◽  
One Pot ◽  
Significant Deterioration ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Green Conditions ◽  
Aryl Methyl ◽  
Operational Simplicity

Abstract Nano-magnetite-supported sulfated polyethylene glycol (Fe3O4@PEG-SO3H) was prepared, characterized and utilized as a magnetically recoverable heterogeneous catalyst for the one-pot, three-component reaction of 2-aminobenzothiazole, aldehydes and 2-naphthol/isatoic anhydride resulting in efficient formation of 1-(benzothiazolylamino)arylmethyl-2-naphthol or dihydroquinazolinones derivatives. The significant features of this method include green conditions, operational simplicity, minimizing production of chemical waste, shorter reaction times and good to high yields. In addition, the nanocatalyst can easily be separated from the reaction mixture by application of a magnetic field and reused without significant deterioration in its catalytic activity.

A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride

2021 ◽  
Vol 76 (2) ◽  
pp. 85-90
Author(s):  
Abdolkarim Zare ◽  
Manije Dianat
Keyword(s):  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Catalyst Amount ◽  
Green Protocol ◽  
Highly Efficient ◽  
Green Approach ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields

Abstract A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.

Rapid and Green One-Pot Synthesis of Novel 2-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-diones

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Zahra Ghahremany ◽  
Madieh Sadeghpour
Keyword(s):  
Aromatic Amines ◽  
Low Cost ◽  
Guanidine Hydrochloride ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields ◽  
Work Up

: A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.

scholarly journals An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

2008 ◽  
Vol 5 (4) ◽  
pp. 688-695 ◽  
Author(s):  
Taoues Boumoud ◽  
Boudjemaa Boumoud ◽  
Salah Rhouati ◽  
Ali Belfaitah ◽  
Abdelmadjid Debache ◽  
...  
Keyword(s):  
Reaction Times ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
First Derivative ◽  
Target Molecules ◽  
The One ◽  
High Yields

The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β-ketoesters and urea. The reaction was carried out in refluxing acetonitrile and afforded the target molecules in good to excellent yields. The method offers several advantages including high yields of the products, short reaction times and easy experimental workup procedure

scholarly journals Leucine: green and efficient catalyst for the synthesis of 4H-chromenes

2017 ◽  
Vol 10 (9) ◽  
pp. 3197-3202 ◽  
Author(s):  
Davood Azarifar ◽  
Younes Abbasi ◽  
Omolbanin Badalkhani
Keyword(s):  
Amino Acid ◽  
Condensation Reaction ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Efficient Catalyst ◽  
Naturally Occurring ◽  
The One ◽  
High Yields ◽  
Work Up

Leucine, a naturally occurring α-amino acid, has been found as an effective catalyst to effect the one-pot three-component condensation reaction between aromatic aldehydes, malononitrile and 5,5-dimethyl-1,3-cyclohexanedione (dimedone). Various 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives are conveniently prepared by these reactions in excellent yields. High yields, short reaction times, simple work-up, use of green and naturally occurring catalyst and solvent are the main merits of the present protocol. 

Green Synthesis of 4-aryl-3,4-Dihydrochromeno[3,4-e][1,3]Oxazine-2,5-Dione in Aqueous Media by Condensation of 4-Hydroxycoumarin with Aromatic Aldehydes and Methyl Carbamate

2017 ◽  
Vol 41 (3) ◽  
pp. 136-138 ◽  
Author(s):  
Sabereh Bougan ◽  
Alireza Hassanabadi
Keyword(s):  
Green Chemistry ◽  
Organic Solvent ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
High Yields

A green and efficient synthesis of the title compounds has been achieved in a one-pot, three-component reaction of 4-hydroxycoumarin and aromatic aldehydes with methyl carbamate catalysed by p-toluenesulfonic acid in aqueous media to afford 4-aryl-3,4-dihydrochromeno[3,4-e][1,3]oxazine-2,5-diones in excellent yields. The salient features of this protocol are: short reaction times, high yields and absence of any hazardous organic solvent. Consequently, this procedure could be classified as green chemistry.

scholarly journals DOWEX(R)50WX4/H2O: A Green System for a One-pot and Three-Component Synthesis of isoxazol-5(4H)-one Derivatives

2017 ◽  
Vol 59 (3) ◽  
Author(s):  
Davood Setamdideh
Keyword(s):  
Present Method ◽  
Reaction Times ◽  
One Pot ◽  
Efficient Approach ◽  
High Yields ◽  
Green System ◽  
Reaction Profile ◽  
Operational Simplicity

A one-pot and three-component synthesis of 3-methyl-4-arylmethyleneisoxazol-5(4<em>H</em>)-ones was developed in the presence of DOWEX(R)50WX4 as the catalyst. The products were obtained in high yields (93-96%) and short reaction times (30-60 min). The present method provides an easy and efficient approach for the synthesis of this class of compounds, because of its clean reaction profile and operational simplicity.

scholarly journals Fe3o4 nanoparticles: A highly efficient and easily reusable catalyst for the one-pot synthesis of xanthene derivatives under solvent-free conditions

2013 ◽  
Vol 78 (6) ◽  
pp. 769-779 ◽  
Author(s):  
Ali Ghasemzadeh ◽  
Javad Safaei-Ghomi ◽  
Safura Zahedi
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Xanthene Derivatives ◽  
The One ◽  
High Yields

Magnetically separable Fe3O4 nanoparticles supply environmentally friendly procedure for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene and 1,8-dioxo-octahydro-xanthene derivatives. These compounds were obtained in high yields and short reaction times by the reaction of dimedone and 2-naphthol with various aromatic aldehydes under solvent-free conditions. The catalyst coluld be easily recovered using an external magnet and reused for six cycles with almost consistent activity.

scholarly journals Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sougata Santra ◽  
Matiur Rahman ◽  
Anupam Roy ◽  
Adinath Majee ◽  
Alakananda Hajra
Keyword(s):  
Knoevenagel Condensation ◽  
One Pot ◽  
Green Protocol ◽  
Microwave Assisted ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Purification Technique ◽  
The One ◽  
High Yields ◽  
Operational Simplicity

A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component condensation of aldehydes, 1,3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure.

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