Functional hearing examinations in patients suffering from diabetes mellitus type 1 in regard to disease duration

Introduction. Problems of hearing disturbances in persons suffering from diabetes have been attracting great attention for many decades. Material and methods. In this study we examined the auditory function of 50 patients suffering from diabetes mellitus type 1 of different duration by analyzing results of pure-tone audiometry and brainstem audi?tory evoked potentials. The obtained results of measuring were compared to 30 healthy subjects from the corresponding age and gender group. The group of diabetic patients was divided according to the disease duration (I group 0-5 years; II group 6-10 years, III group over 10 years). Results and discussion. A statistically significant increase of sensorineural hearing loss was found in the diabetics according to the duration of their disease (I group = 14.09%, II group = 21.39%, III group = 104.89%). The results of the brain stem auditory evoked potentials, the significance threshold being p=0.05 between the controls and the diabetics at all levels of absolute latency of right and left sides, did not show significant differences in the mean values. In the case of interwave latencies, the diabetic patients were found to have a significant qualitative difference of intervals I-III and I-V on both ears in the sense of internal distribution of response. In cases of sensorineural hearing loss we found a significant connection with prolonged latencies of I wave on the right ear and of I and V waves on the left ear. In all probability, the cause of these results could be found in distinctive individuality of the organism reactions to the consequences of this disease (disturbance in the distal part of n. cochlearis). Conclusion. The results of research have shown the existence of a significant sensorineural hearing loss in the patients with diabetes mellitus type 1 in accordance to the disease duration. We also found qualitative changes of brainstem auditory evoked potentials in the diabetic patients in comparison to the controls as well as significant quantitative changes in regard to the presence of sensorineural hearing loss of the patients.

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Correlation of hearing function findings in regard to other, subsequent complication of diabetes mellitus type 1

Medicinski pregled ◽

10.2298/mpns0912517p ◽

2009 ◽

Vol 62 (11-12) ◽

pp. 517-521

Author(s):

Goran Pudar ◽

Liljana Vlaski ◽

Danka Filipovic ◽

Ilija Tanackov

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Auditory Evoked Potentials ◽

Diabetes Mellitus Type 1 ◽

Sensorineural Hearing ◽

Diabetes Mellitus Type ◽

Brainstem Auditory Evoked Potentials ◽

The Right

Introduction. Hearing loss is considered to be a subsequent complication of diabetes. Material and methods. Auditory function was analyzed in 50 patients suffering from diabetes mellitus type I, and through results of pure-tone audiometry and brainstem auditory evoked potentials in regard to the existence of subsequent complications of the disease, diabetic neuropathy (n = 20) and retinopathy (n = 13). Results and discussion. The results were correlated with the ones in those having a disease, but without these complications and the control group of 30 healthy examinees of the adequate gender and age. Patients suffering from this disease for over 10 years (83.33%), were found to have high frequency of diabetic neuropathy, increased average sensorineural hearing loss (73.04%). The average age was significantly higher (35.5 ? (3SD = 5.3) in accordance with 23.2? (3 SD = 6.3), and the disease lasted much longer (17.5 years towards 5.7 years) in those suffering from neuropathy. In the presence of diabetic retinopathy it was found that the average sensorineural hearing loss was increased for 50.43%, in comparison to those without signs of retinopathy. The average sensorineural hearing loss was found to be higher for 62.58% to 76.81% in patients with retinopathy preproliferance and retinopathy profilerance than in those with established retinopathy nonproliferance. In the presence of diabetic retinopathy, a significant difference was observed in latencies of III and IV waves from the right, and latencies of I, IV and V waves from the left ear, this is, interwaves latencies of I-III on the right ear and III-V and I-V on the left ear. Conclusion.. Subsequent complications of diabetes mellitus type 1 (neuropathy and retinopathy) have positive correlation with the significant level of sensorineural hearing loss, particulary expressed in function of patients' age, and latencies extention of brainstem auditory evoked potentials.

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Enhanced Apoptosis of Monocytes from Complication-Free Juvenile-Onset Diabetes Mellitus Type 1 May Be Ameliorated by TNF-αInhibitors

Mediators of Inflammation ◽

10.1155/2014/946209 ◽

2014 ◽

Vol 2014 ◽

pp. 1-11 ◽

Cited By ~ 7

Author(s):

Jolanta Myśliwska ◽

Monika Ryba-Stanisławowska ◽

Marcin Smardzewski ◽

Bartosz Słomiński ◽

Małgorzata Myśliwiec ◽

...

Keyword(s):

Diabetes Mellitus ◽

Microvascular Complications ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Diabetic Patients ◽

Monocyte Subsets ◽

Juvenile Onset ◽

Monocyte Apoptosis ◽

Juvenile Onset Diabetes

Diabetes mellitus type 1 is associated with an enhanced apoptosis of different cells and tissues, accelerating occurrence of diabetic microvascular complications. The aim of our study was to determine spontaneous apoptotic potential of the monocyte subsets in juvenile-onset complication-free diabetes mellitus type 1 and to compare them with the corresponding values of the healthy. Moreover, we wanted to assess effects of TNF-R1 blocking agents and those of general TNF-αblocker (Infliximab) on spontaneous apoptosis of monocytes. Sixty randomly selected DM1 patients (14.5 ± 3.2 years) and 30 healthy (13.5 ± 2.8 years) volunteers were enrolled in the study. Our results indicate that three monocyte subsets are distinguishable in the groups of young diabetic patients and the healthy, similarly to in the blood of adults. DM1 patients were characterized by higher values of apoptotic monocytes than the healthy. The manipulation with drugs inhibiting TNF-R1 expression diminished the pool of CD16+apoptotic monocytes. Infliximab reduced the apoptotic CD16−cells. In conclusion, diabetes mellitus type 1 is associated with greater apoptosis of three monocyte subsets which may contribute to the development of microvascular complications. TNF-αmodifiers appear to ameliorate monocyte apoptosis. They may be useful for controlling excessive monocyte apoptosis in diabetic patients.

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Peculiarities of Physical Activity and Self‑Esteem of Young People with Diabetes Mellitus Type 1 and Healthy Persons Aged 18–25 Years

Baltic Journal of Sport and Health Sciences ◽

10.33607/bjshs.v4i83.305 ◽

2018 ◽

Vol 4 (83) ◽

Author(s):

Sandrija Čapkauskienė ◽

Daiva Vizbaraitė ◽

Deimantė Šeštokaitė

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Healthy Subjects ◽

Self Esteem ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Diabetic Patients ◽

Patients With Diabetes ◽

Healthy Persons

Research background and hypothesis. Careful diabetes control slows the onset and progression of life-threatening complications, the development of disability and early disability-related unemployment, and prolongs life expectancy (Danytė et al., 2000). The benefits of physical activity on regular basis comprise improved cardiovascular health, increased lean body mass, improved blood lipid profile, enhanced psycho-social wellbeing and decreased obesity (Riddell, Iscoe, 2006). Physical activity is one of the main factors influencing glucose level in diabetic patients’ blood (Wiśniewski, 2010). Analysis of self-esteem of the studied revealed a wide range of findings, from trying to outline the modest achievements, pride, and even unwillingness to discuss it to low self-esteem, feeling of guilt and self-reproach for mistakes and failures (Žemaitis, 1995). The aim of the study was to determine physical activity and self-esteem of healthy subjects and patients with diabetes mellitus type 1 aged 18–25 years.Methods. The study included 140 individuals (aged from 18 to 25 years). Among 41 patients with type 1 diabetes mellitus there were 33 young women and 8 young men, and among 99 healthy persons – 79 young women and 29 young men. All the subjects were asked to fill in the questionnaire orientated to physical activity and self-esteem. The short IPAQ questionnaire was used to research physical activity and Rosenberg’s Self-Esteem Scale was used to assess self esteem.Research results. Approximately 60% of subjects with diabetes mellitus type 1 and about 50% of healthy persons rated their physical activity as moderate. Intensive 60-minute-physical activity was reported by 48.5% of healthy subjects and 34.1% of diabetic patients, moderate 60-minute-physical activity was pointed out by 38.2% of diabetic patients and 35.8% of healthy research participants. The largest walking interval was 1–1.5 hours: in the diabetic group– 28.8%, in the healthy group – 31.65%. Healthy young men and women were physically more active than diabetic patients. Self-esteem in both genders of healthy subjects and diabetic patients was determined as moderate.Discussion and conclusions. Physical activity of women and men with diabetes mellitus type 1 aged 18–25 years was valued as moderate, meanwhile physical activity in healthy persons – moderate or high. Self-esteem is moderate in both groups of patients with diabetes and healthy persons. Healthy men are more active than diabetic patients, similarly, women having diabetes mellitus type 1 are more physically passive than healthy ones. Both patients with diabetes mellitus type 1 and healthy individuals aged 18–25 reported moderate self-esteem.Keywords: diabetes mellitus type 1, physical activity, self-esteem.

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Sensorineural hearing loss and type II diabetes mellitus

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20180714 ◽

2018 ◽

Vol 4 (2) ◽

pp. 499

Author(s):

Kavita Sachdeva ◽

Saima Azim

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Glycemic Control ◽

Sensorineural Hearing Loss ◽

Hearing Threshold ◽

Sensorineural Hearing ◽

Diabetic Patients ◽

Hearing Level ◽

Type Ii ◽

Uncontrolled Diabetes

Background: The association between Hearing loss and diabetes, first mentioned by Jardao in 1857, had been under continuous research since then; giving both positive and negative results. This study aims to explore the relationship of hearing loss with type II DM and also to evaluate the impact of glycemic control over degree of hearing loss. Methods: 92 patients with type II DM were enrolled in this study, audiometrically evaluated and compared with equal number of age and sex matched non-diabetic controls. Apart from audiological tests, haematological tests like FBS, PPBS, HbA1c, serum creatinine and cholesterol were carried out to assess glycemic control. Results: It was observed that 31 (34%) of the diabetic patients had mild to moderate sensorineural hearing loss, while only 12 (13%) of the control group suffered from the same, which is statistically significant (p<0.05). Among these 31 patients, 19 (61%) patients had uncontrolled diabetes (HbA1c >8.5) and 12 (39%) had higher creatinine levels (>2.5 mg/dl). Higher frequencies (4 and 8 kHz) were found to be affected more, both in case and control groups. Low stapedial reflex thresholds were observed in 14% patients of case group and 5.4% of the controls. Speech discrimination scores were not significantly different. Otoacoustic emission showed outer hair cell dysfunction in 85% cases and 66% controls. Conclusions: There is a strong correlation between diabetes mellitus and hearing threshold levels especially at higher frequencies. Long duration and uncontrolled diabetes has more implications over hearing threshold. Since the pattern of hearing loss in diabetes and presbycusis is similar, it may be said that hearing level with ageing is significantly impaired earlier in diabetic patients as compared to general population.

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Patterns of Otorhinolaryngological Disorders in Subjects with Diabetes

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v10i2.676 ◽

2020 ◽

Vol 10 (2) ◽

Author(s):

Gazzaz ZJ ◽

Makhdom MN ◽

Dhafar KO ◽

Maimini O ◽

Farooq MU ◽

...

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Saudi Arabia ◽

Sensorineural Hearing Loss ◽

Diabetes Mellitus Type 2 ◽

Sensorineural Hearing ◽

Diabetes Mellitus Type ◽

Patients With Diabetes ◽

Hba1c Levels

Objective: To find out the prevalence of otorhinolaryngological disorders in patients with diabetes mellitus who presented to Ear, Nose and Throat (ENT) clinic at Al-Noor specialist hospital, Makkah, Saudi Arabia. Materials & Methods: This observational retrospective study was carried out over a period of one year, from July 15, 2004 to July 20, 2005 by the collaboration of ENT Department and Health Research Center of Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Patients’ information was collected such as the demography, types and durations of diabetes, types of diabetic treatments, and fi nal ENT diagnosis. Subjects’ random blood sugar and hemoglobin A1c (HbA1c) levels were collected on the fi rst visit to the ENT-Outpatient Department. Results: One hundred patients met the inclusion criteria; with mean age of 51.5 years (age range 14-86 years). Thirty-nine percent of the patients were at the age of 45-54 years old. Males (52%) slightly out-numbered the females. Majority had diabetes mellitus type 2 and 78% patients had high HbA1c levels indicating poor glycemic controls. The most common ENT disorder was rhinitis (19%), followed by sensorineural hearing loss (12%) and malignant otitis externa (8%). Conclusion: The most common ENT disorder in patients with diabetes mellitus type 2 was rhinitis, followed by sensorineural hearing loss. Majority of these patients had poor glycemic control, hence can explain the predominance of certain disorders over others.

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Inhibition of 2C Coxsackie B Virus Protein to Decrease Pathogenicity of Diabetes Mellitus Type 1

Current Computer - Aided Drug Design ◽

10.2174/1573409915666190820154422 ◽

2020 ◽

Vol 16 (3) ◽

pp. 318-326

Author(s):

Amina Amin ◽

Muhammad A. Rasheed ◽

Rana A. Diwan ◽

Muhammad Shahid ◽

Saddia Bano ◽

...

Keyword(s):

Diabetes Mellitus ◽

Environmental Factors ◽

Small Rna ◽

Rna Virus ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Diabetic Patients ◽

Lead Compounds ◽

Coxsackie B4 Virus

Background: Insulin-dependent Diabetes Mellitus Type 1 (T1D) also referred to as autoimmune diabetes. T1D is a chronic disease which is characterized by way of insulin deficiency. The deficiency is due to the loss of pancreatic β cells and leads to hyperglycemia. There are many factors which play a significant role in T1D disease pathogenicity including genetic predisposition, the immune system, and environmental factors. The environmental factors may include Coxsackie B4 virus, a small RNA virus. Objective: The objective of current in silico study is to identify active lead compounds against Coxsackie B4 virus, a small RNA virus which has been reported in diabetic patients after PCR. There is a need to predict inhibitors against TID caused by Coxsackie B4 viral protein that may be used as a drug against TID in the future. Methods: For this purpose, different bioinformatics databases and tools were used. The protein structure generation and validation, retrieval of ligands and their properties analysis were performed by different databases, web servers, and software tools. Moreover, the docking tools were used to identify the target site of the protein and interaction of different inhibitors with the target protein molecule. Results: Based on the analysis, two lead compounds ZINC00034488 and ZINC00034585 were selected as potential drugs. These compounds are non-toxic and have best interaction energy and fulfill Lipinski rule, Veber rule, Ghose Rule, Weighted QED, Unweighted QED and BBB likeness parameters. Conclusion: Our work will help researchers to get an idea about the understanding of chemicals against Coxsackie B4 Viruses and helpful to design a drug and test these chemicals to overcome Diabetes Mellitus Type 1 caused by Coxsackie B4 virus.

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