An undecidable problem in finite combinatorics

1984 ◽  
Vol 49 (3) ◽  
pp. 842-850 ◽  
Author(s):  
Kevin J. Compton

Problems of computing probabilities of statements about large, finite structures have become an important subject area of finite combinatorics. Within the last two decades many researchers have turned their attention to such problems and have developed a variety of methods for dealing with them. Applications of these ideas include nonconstructive existence proofs for graphs with certain properties by showing the properties occur with nonzero probabilities (for examples see Erdös and Spencer [ES] and Bollobás [Bo]), and determination of average running times for sorting algorithms by computing asymptotic probabilities of statements about permutations (see Knuth [Kn]). Two types of techniques recur in solutions to such problems: probabilistic techniques, such as those used by Erdös and Spencer [ES], and classical assymptotic techniques, such as those surveyed by Bender [Be] and de Bruijn [Br]. Studying this body of techniques, one notices that characteristics of these problems suggest certain methods of solution, in much the same way that the form of an integrand may suggest certain substitutions. The question arises, then, as to whether there is a systematic way to approach these problems: is there an algorithm for computing asymptotic probabilities? I will show that the answer is “no”—for any reasonable formulation, the problem of computing asymptotic probabilities is undecidable.The main theorem of the paper is Theorem 1.6, which says that there is a finitely axiomatizable class in which every first order sentence has an asymptotic probability of 0 or 1—i.e., is almost always true or almost always false in finite structures—but for which the problem of deciding whether a sentence has asymptotic probability 0 or 1 is undecidable. Heretofore, classes known to have such a 0-1 law have had decidable asymptotic probability problems (see Lynch [Ly] for examples and a discussion of previous work in the area).

1996 ◽  
Vol 76 (01) ◽  
pp. 005-008 ◽  
Author(s):  
Jean Claude Lormeau ◽  
Jean Pascal Herault ◽  
Jean Marc Herbert

SummaryWe examined the effect of the synthetic pentasaccharide representing the minimal binding site of heparin to antithrombin on the antithrombin-mediated inactivation of factor Vila bound to tissue factor. This effect was compared to the effect of unfractionated heparin. Using purified recombinant human coagulation factors and either a clotting or an amidolytic assay for the determination of the residual activity of factor Vila, we showed that the pentasaccharide was an efficient antithrombin-dependent inhibitor of the coagulant activity of tissue factor-factor Vila complex. In our experimental conditions, assuming a mean MW of 14,000 for heparin, the molar pseudo-first order rate constants for ATIII-mediated FVIIa inhibition by ATIII-binding heparin and by the synthetic pentasaccharide were found to be similar with respective values of 104,000 ± 10,500 min-1 and 112,000 ± 12,000 min-1 (mean ± s.e.m., n = 3)


2018 ◽  
Vol 84 (11) ◽  
pp. 74-87
Author(s):  
V. B. Bokov

A new statistical method for response steepest improvement is proposed. This method is based on an initial experiment performed on two-level factorial design and first-order statistical linear model with coded numerical factors and response variables. The factors for the runs of response steepest improvement are estimated from the data of initial experiment and determination of the conditional extremum. Confidence intervals are determined for those factors. The first-order polynomial response function fitted to the data of the initial experiment makes it possible to predict the response of the runs for response steepest improvement. The linear model of the response prediction, as well as the results of the estimation of the parameters of the linear model for the initial experiment and factors for the experiments of the steepest improvement of the response, are used when finding prediction response intervals in these experiments. Kknowledge of the prediction response intervals in the runs of steepest improvement of the response makes it possible to detect the results beyond their limits and to find the limiting values of the factors for which further runs of response steepest improvement become ineffective and a new initial experiment must be carried out.


Author(s):  
Pratik S Mehta ◽  
Pratik R. Patel ◽  
Rajesh R Parmar ◽  
M M K Modasiya ◽  
Dushyant A Shah

A novel, simple, accurate, sensitive, precise and economical derivative spectroscopic method was developed and validated for the determination of cefadroxil and probenecid in synthetic mixture. First order derivative spectroscopy method was adopted to eliminate spectral interference. The method obeys Beer’s Law in concentration ranges of 4-36 μg/ml for cefadroxil and of 5-25 μg/ml of probenecid. The zero crossing point for cefadroxil and probenecid was 260 nm and 237.8 nm respectively in 0.1N HCl. The method was validated in terms of accuracy, precision, linearity, limits of detection, limits of quantitation. This method has been successively applied to synthetic mixture and no interference from the synthetic mixture’s excipients was found.   


2021 ◽  
Vol 82 (2) ◽  
Author(s):  
Robin Hirsch ◽  
Jaš Šemrl

AbstractThe motivation for using demonic calculus for binary relations stems from the behaviour of demonic turing machines, when modelled relationally. Relational composition (; ) models sequential runs of two programs and demonic refinement ($$\sqsubseteq $$ ⊑ ) arises from the partial order given by modeling demonic choice ($$\sqcup $$ ⊔ ) of programs (see below for the formal relational definitions). We prove that the class $$R(\sqsubseteq , ;)$$ R ( ⊑ , ; ) of abstract $$(\le , \circ )$$ ( ≤ , ∘ ) structures isomorphic to a set of binary relations ordered by demonic refinement with composition cannot be axiomatised by any finite set of first-order $$(\le , \circ )$$ ( ≤ , ∘ ) formulas. We provide a fairly simple, infinite, recursive axiomatisation that defines $$R(\sqsubseteq , ;)$$ R ( ⊑ , ; ) . We prove that a finite representable $$(\le , \circ )$$ ( ≤ , ∘ ) structure has a representation over a finite base. This appears to be the first example of a signature for binary relations with composition where the representation class is non-finitely axiomatisable, but where the finite representation property holds for finite structures.


2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Vu Dang Hoang ◽  
Dong Thi Ha Ly ◽  
Nguyen Huu Tho ◽  
Hue Minh Thi Nguyen

The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimized to give the highest spectral recoveries. Calibration graphs in the linear concentration ranges of ibuprofen (12–32 mg/L) and paracetamol (20–40 mg/L) were obtained by measuring the amplitudes of the transformed signals. Our proposed spectrophotometric methods were statistically compared to HPLC in terms of precision and accuracy.


2017 ◽  
Vol 10 (5) ◽  
pp. 604-610 ◽  
Author(s):  
Rúbia A. Sversut ◽  
Isabella C. Alcântara ◽  
Aline M. Rosa ◽  
Adriano C.M. Baroni ◽  
Patrik O. Rodrigues ◽  
...  

2012 ◽  
Vol 588-589 ◽  
pp. 359-363
Author(s):  
Jian Ping Sun ◽  
Jian Xin Wang

the columns of magnetostrictive transducer for the object, the establishment of a Radiant Panel in magnetostrictive rods through the spring of motion model, gives a method for solving first-order analysis and solutions, discusses the spring rate on radiation effect of amplitude. On reasonable determination of Radiant Panel structure, the size of the transducer, and optimization methods.


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