Purification, Characterization, and the Presumptive Role of Fumarase in the Energy Metabolism of Ascaris suum

1979 ◽  
Vol 65 (6) ◽  
pp. 833 ◽  
Author(s):  
D. Michael Payne ◽  
David G. Powley ◽  
Ben G. Harris

Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.





2019 ◽  
Author(s):  
Min Pi ◽  
Fuyi Xu ◽  
Ruisong Ye ◽  
Satoru K. Nishimoto ◽  
Robert A. Kesterson ◽  
...  


Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 608
Author(s):  
Domenico Nuzzo

All cells continuously generate reactive oxygen species (ROS) through the respiratory chain during the energy metabolism process [...]



1994 ◽  
Vol 161 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Bernd Kreke ◽  
Heribert Cypionka


2004 ◽  
Vol 36 (4) ◽  
pp. 252-261 ◽  
Author(s):  
Yi‐Hao Yu ◽  
Henry Ginsberg
Keyword(s):  


Endocrine ◽  
2017 ◽  
Vol 58 (1) ◽  
pp. 3-13 ◽  
Author(s):  
William Gustavo Lima ◽  
Gleuber Henrique Marques-Oliveira ◽  
Thaís Marques da Silva ◽  
Valéria Ernestânia Chaves


2017 ◽  
Vol 66 (1) ◽  
pp. S335-S336
Author(s):  
F. Luciano ◽  
N. Cabré ◽  
A. Hernandez-Aguilera ◽  
G. Baiges-Gaya ◽  
A. Garcia-Heredia ◽  
...  
Keyword(s):  


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