399 COMPARISON OF COGNITIVE FUNCTION AND QUALITY OF LIFE IN WOMEN WITH HYPOPITUITARISM: ROLE OF ANDROGENS

About 1 of every 8 women will develop breast cancer during her lifetime, and approximately 250,000 new cancer cases are expected annually as of 2017. Of those breast cancers, approximately 60% to 75% will express estrogen receptors, suggesting that estrogens are likely to promote growth of those tumors. Because the use of inhibitors of the synthesis of estrogens is the adjuvant treatment of choice for many women, it is essential that we understand the potential adverse effects on quality of life of those treatments. This review addresses the role of estrogens locally synthesized in the brain in laboratory animals and women, the effects of estrogens on cognitive function, the effects of synthesis blockers on cognitive function, and the limitations in performing experiments that will give us strong confidence in the results and conclusions.

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Treatments for Breast Cancer That Affect Cognitive Function in Postmenopausal Women

Policy Insights from the Behavioral and Brain Sciences ◽

10.1177/2372732217717271 ◽

2017 ◽

Vol 4 (2) ◽

pp. 170-177 ◽

Cited By ~ 5

Author(s):

Jeffrey D. Blaustein

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cognitive Function ◽

Develop Breast Cancer ◽

Laboratory Animals ◽

Breast Cancers ◽

Estrogen Synthesis ◽

The Brain

About one of every eight women will develop breast cancer during her lifetime. Approximately a quarter of a million new cancer cases are expected in 2017. Of those breast cancers, 60% to 75% will have characteristics suggesting that estrogens are likely to promote growth of those tumors. Consequently, inhibiting estrogen synthesis is one of the main treatments of choice. Therefore, women must understand the potential adverse effects of those treatments on quality of life. This review discusses (a) the role of estrogens locally synthesized in the brain in laboratory animals and women, (b) the effects of estrogens and blockers of estrogen synthesis on cognitive function, and (c) the limitations in experiments on women taking inhibitors. This article aims to provide women and oncologists with information that will encourage them to consider side effects of aromatase inhibitors (AIs) treatment on the brain.

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Yoga as Therapy for People With Aphasia

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-20-00028 ◽

2020 ◽

Vol 5 (4) ◽

pp. 853-860

Author(s):

Aimee Dietz ◽

E. Susan Duncan ◽

Lauren Bislick ◽

Sarah Stegman ◽

Jenna Collins ◽

...

Keyword(s):

Quality Of Life ◽

Cognitive Function ◽

Social Integration ◽

Social Interactions ◽

Chronic Conditions ◽

Potential Impact ◽

And Coping ◽

Body Practices

Purpose This viewpoint offers a perspective on the potential impact of an adapted yoga program for people with stroke-induced aphasia, with a call for additional work in this area. Conclusion Aphasia often results in decreased quality of life (QoL) from fewer social interactions, relationship strain between survivors and co-survivors, depression, and a multitude of other factors. We suggest a therapeutic yoga program for survivors and co-survivors could enhance several components of the dyad's lives that are frequently diminished as a result of aphasia, ultimately increasing QoL. In particular, we highlight the role of resilience and coping as essential tools on the rehabilitative journey in aphasia. After exploring yoga and other mind–body practices, we describe documented positive changes—including cognitive function, social integration, and QoL—following use of yoga in other chronic conditions. As people with communication deficits are typically excluded from these studies, further research is needed to establish whether these benefits generalize to people with aphasia.

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