Treatments for Breast Cancer That Affect Cognitive Function in Postmenopausal Women

2017 ◽  
Vol 4 (2) ◽  
pp. 170-177 ◽  
Author(s):  
Jeffrey D. Blaustein
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cognitive Function ◽  
Develop Breast Cancer ◽  
Laboratory Animals ◽  
Breast Cancers ◽  
Estrogen Synthesis ◽  
The Brain

About one of every eight women will develop breast cancer during her lifetime. Approximately a quarter of a million new cancer cases are expected in 2017. Of those breast cancers, 60% to 75% will have characteristics suggesting that estrogens are likely to promote growth of those tumors. Consequently, inhibiting estrogen synthesis is one of the main treatments of choice. Therefore, women must understand the potential adverse effects of those treatments on quality of life. This review discusses (a) the role of estrogens locally synthesized in the brain in laboratory animals and women, (b) the effects of estrogens and blockers of estrogen synthesis on cognitive function, and (c) the limitations in experiments on women taking inhibitors. This article aims to provide women and oncologists with information that will encourage them to consider side effects of aromatase inhibitors (AIs) treatment on the brain.

Considerations on the Use of Aromatase Inhibitors in Postmenopausal Women With Breast Cancer

2020 ◽  
pp. 385-400
Author(s):  
Jeffrey D. Blaustein
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cognitive Function ◽  
Adverse Effects ◽  
Develop Breast Cancer ◽  
Laboratory Animals ◽  
Breast Cancers ◽  
The Brain

About 1 of every 8 women will develop breast cancer during her lifetime, and approximately 250,000 new cancer cases are expected annually as of 2017. Of those breast cancers, approximately 60% to 75% will express estrogen receptors, suggesting that estrogens are likely to promote growth of those tumors. Because the use of inhibitors of the synthesis of estrogens is the adjuvant treatment of choice for many women, it is essential that we understand the potential adverse effects on quality of life of those treatments. This review addresses the role of estrogens locally synthesized in the brain in laboratory animals and women, the effects of estrogens on cognitive function, the effects of synthesis blockers on cognitive function, and the limitations in performing experiments that will give us strong confidence in the results and conclusions.

scholarly journals Effect of Baduanjin exercise intervention on cognitive function and quality of life in women with breast cancer receiving chemotherapy: study protocol of a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiao-Lin Wei ◽  
Ru-Zhen Yuan ◽  
Yong-Mei Jin ◽  
Shu Li ◽  
Ming-Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Trial ◽  
Cognitive Function ◽  
Exercise Intervention ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Pharmacological Intervention ◽  
Control Group

Abstract Background More than 50% cognitive impairment was reported by cancer patients before and after medical treatment. However, there are no effective interventions to manage the cognitive problem in women with breast cancer. This pilot study was designed to evaluate the protective effect of Baduanjin exercise on cognitive function and cancer-related symptoms in women with early-stage breast cancer undergoing chemotherapy. Method A single-blinded, randomized control trial was designed. The trial will recruit 70 patients with early-stage breast cancer scheduled to receive chemotherapy from Shanghai in China. All participants will be randomly assigned to (1:1) the supervised Baduanjin group (5 times/week, 30 min each time) or the wait-list control group for 3 months. The effect of Baduanjin exercise intervention will be evaluated by outcome measures including subjective and objective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 8 weeks (T1), and 12 weeks (T2). The PCI score in the FACT-Cog as the primary cognitive outcome will be reported descriptively, while effect sizes and 95% confidence intervals (CIs) will be calculated. The collected data will be analyzed by using an intention-to-treat principle and linear mixed-effects modeling. Discussion This is the first randomized clinical trial to investigate whether Baduanjin exercise will have a positive role in improving cognitive function in women with breast cancer receiving chemotherapy. If possible, Baduanjin exercise will be a potential non-pharmacological intervention to manage cognitive dysfunction and promote survivorship care among breast cancer survivors. Trial registration Chinese Clinical Trial Registry (ChiCTR) ChiCTR2000033152. Registered on 22 May 2020

399 COMPARISON OF COGNITIVE FUNCTION AND QUALITY OF LIFE IN WOMEN WITH HYPOPITUITARISM: ROLE OF ANDROGENS

2005 ◽  
Vol 53 (1) ◽  
pp. S148.3-S148
Author(s):  
E. Zuckerbraun ◽  
M. Garcia ◽  
B. Tran ◽  
Bhasin S. T.C. Friedman
Keyword(s):  
Quality Of Life ◽  
Cognitive Function

Psychological distress and quality of life among Jordanian women diagnosed with breast cancer: The role of trait mindfulness

2019 ◽  
Vol 28 (5) ◽  
Author(s):  
Suhair Hussni Al‐Ghabeesh ◽  
Mahmoud Al‐Kalaldah ◽  
Ahmad Rayan ◽  
Anwar Al‐Rifai ◽  
Fadwa Al‐Halaiqa
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Psychological Distress ◽  
Trait Mindfulness

scholarly journals Fungsi Kognitif dengan Kualitas Hidup Pada Lansia

2021 ◽  
Vol 7 (1) ◽  
pp. 34
Author(s):  
Maria Manungkalit ◽  
Ni Putu Wulan Purnama Sari ◽  
Ninda Ayu Prabasari
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Brain Function ◽  
Selection Criteria ◽  
Cross Sectional ◽  
Normal Cognitive Function ◽  
Cross Sectional Design ◽  
The Brain ◽  
Elderly Living

As age increases, various body deteriorioration will follow, one of them is cognitive function. The brain function of memory recall or remembering something is part of cognitive function. If this function weaken, daily activities will be disturbed and may have impacts on quality of life. This study aimed to analyze the correlation between cognitive function and quality of life in elderly. This was a cross-sectional design. Population was all elderly living in a private nursing home in Surabaya (N=150). Based on sample's selection criteria, there were 145 elderly participated as respondents. Instruments used were Mini Mental State Exam (MMSE) for measuring cognitive function, and Older People Quality of Life (OPQOL) for measuring quality of life in elderly. Most respondents had normal cognitive function, but their quality of life was mostly sufficient. Statistical analysis by Spearman's Rho correlation test showed that cognitive function was significantly correlated with quality of life in elderly (p=0.008). The aging process has impact on cognitive function deterioration which resulted in a decrease in elderly's quality of life.  Keywords: cognitive function, elderly, quality of life

scholarly journals The Mode of Detection Is Not Associated with Quality of Life in Women with Breast Cancer

Breast Care ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 498-505
Author(s):  
Bettina Braun ◽  
Marc-André Kurosinski ◽  
Laura Khil ◽  
Joke Tio ◽  
Barbara Krause-Bergmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Tumor Stage ◽  
Screening Mammography ◽  
Influential Factors ◽  
Breast Cancers ◽  
Interval Cancers ◽  
Screening Programs ◽  
Mode Of Detection

Introduction: Apart from saving lives, mammography screening programs (MSP) are expected to reduce negative side effects of treatment by detecting cancer earlier, when it is more responsive to less aggressive treatment. This study compared quality of life (QoL) among women with breast cancers that were detected either by screening mammography, as interval cancers, or clinically among women not participating in the MSP. Methods: Retrospective study of first-ever invasive breast cancers detected among MSP-eligible women aged 50–69 years between 2006 and 2012 in Münster, Germany. EORTC QLQ-C30 and -BR23 questionnaires were mailed to 1,399 cases still alive in 2015 (response rate 64.1%). Results: Women’s responses were obtained on average 6.1 years after diagnosis. Mean crude and age-adjusted scores for overall QoL, breast and body image (BBI), and five functional scales (FS) were comparable between groups of detection mode. Clearly lower adjusted means for most scores were observed in women with interval cancers, if time since diagnosis was less than 5 years. Cases younger than 60 years showed lower values for some FS, particularly among interval and screen-detected cases. Discussion/Conclusion: In summary, cases with breast cancer showed health-related score values that were similar to the general population of the same age. There was also no indication that mode of detection markedly influenced these scores. However, after adjusting for tumor stage and other influential factors, screening participants appeared more susceptible to score declines after a diagnosis of cancer than non-participants.

Mindfulness and Quality of Life in Cancer Survivors: The Mediating Role of Self-Kindness and Alexithymia

2016 ◽  
Vol 38 (4) ◽  
pp. 346-359 ◽  
Author(s):  
Allison M. Forti ◽  
Craig S. Cashwell ◽  
Robert Henson
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Post Treatment ◽  
Significant Variance ◽  
Mediating Role ◽  
The Relationship

The purpose of this study was to understand the relationship among mindfulness, self-kindness, alexithymia and quality of life in post-treatment breast cancer survivors and to examine whether self-kindness and alexithymia mediate the relationship between mindfulness and quality of life. Results suggested that the overall model accounted for significant variance in quality of life and that alexithymia partially mediated the relationship between mindfulness and quality of life. Implications for practice and further research are discussed.

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