Sarcoidosis Can Present with Necrotizing Granulomas Histologically: Two Cases of Ulcerated Sarcoidosis and Review of the Literature

2013 ◽  
Vol 17 (6) ◽  
pp. 377-383 ◽  
Author(s):  
Kristin Noiles ◽  
Katie Beleznay ◽  
Richard I. Crawford ◽  
Sheila Au
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Disorder ◽  
Review Of The Literature ◽  
Cutaneous Sarcoidosis ◽  
Cutaneous Lesions ◽  
Delay In Diagnosis ◽  
Cutaneous Involvement ◽  
Histopathologic Findings ◽  
Histopathologic Features ◽  
Necrotizing Granulomas

Background: Sarcoidosis is a systemic inflammatory disorder with cutaneous involvement present in 25% of cases. The presence of naked granulomas histologically is the hallmark of sarcoidosis. The presence of necrotizing granulomas is highly suggestive of other granulomatous conditions and leads the clinician to pursue other diagnoses, such as infectious causes. Objectives: We describe two cases of sarcoidosis in which necrotizing granulomas were present on biopsy. Both patients had ulcerated cutaneous lesions of sarcoidosis. In one case, the presence of these atypical histologic features led to a delay in diagnosis of almost 10 years. We review the various histopathologic findings associated with cutaneous sarcoidosis and discuss a potential connection between ulcerated sarcoidosis and atypical histologic findings. Conclusion: When atypical histopathologic features are present, the differential diagnosis of sarcoidosis should not be excluded.

scholarly journals Adaptive Immune Responses in Primary Cutaneous Sarcoidosis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Matteo Bordignon ◽  
Paola Rottoli ◽  
Carlo Agostini ◽  
Mauro Alaibac
Keyword(s):  
Dendritic Cells ◽  
Treatment Strategies ◽  
Immunological Response ◽  
Inflammatory Disorder ◽  
Cutaneous Sarcoidosis ◽  
Cutaneous Lesions ◽  
Adaptive Immune ◽  
Immunological Mechanisms ◽  
Adaptive Immune Systems

Sarcoidosis is a multisystemic inflammatory disorder with cutaneous lesions present in about one-quarter of the patients. Cutaneous lesions have been classified as specific and nonspecific, depending on the presence of nonnecrotizing epithelial cell granulomas on histologic studies. The development and progression of specific cutaneous sarcoidosis involves a complex interaction between cells of the adaptive immune systems, notably T-lymphocytes and dendritic cells. In this paper, we will discuss the role of T-cells and skin dendritic cells in the development of primary cutaneous sarcoidosis and comment on the potential antigenic stimuli that may account for the development of the immunological response. We will further explore the contributions of selected cytokines to the immunopathological process. The knowledge of the adaptive immunological mechanisms operative in cutaneous sarcoidosis may subsequently be useful for identifying prevention and treatment strategies of systemic sarcoidosis.

Esophageal Melanocytosis Morphologic Features and Review of the Literature

2006 ◽  
Vol 130 (4) ◽  
pp. 552-557 ◽  
Author(s):  
Fuju Chang ◽  
Harriet Deere
Keyword(s):  
Differential Diagnosis ◽  
Squamous Epithelium ◽  
Natural Course ◽  
Bibliographic Databases ◽  
Review Of The Literature ◽  
Histopathologic Features

Abstract Endoscopic or macroscopic esophageal melanocytosis is a benign clinicopathologic entity characterized by melanocytic proliferation in esophageal squamous epithelium and melanin deposition in the mucosa. Little is known about the etiology and natural course of this condition, although it has been suggested to be a precursor of primary esophageal melanoma by some authors. Following a search of the bibliographic databases (PubMed and Medline) regarding esophageal melanocytosis and melanosis, thirty-four cases of isolated esophageal melanocytosis (including one unpublished case from us) were found. The histopathologic features of esophageal melanocytosis are reviewed and its differential diagnosis with other pigmented esophageal lesions is discussed.

scholarly journals Dendritic Fibromyxolipoma of the Pyriform Sinus: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Abdulrahim AlAbdulsalam ◽  
Maha Arafah
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Spindle Cell ◽  
Pyriform Sinus ◽  
Vascular Pattern ◽  
Review Of The Literature ◽  
Spindle Cell Lipoma ◽  
Soft Tissue Neoplasm ◽  
Cytoplasmic Processes ◽  
Histopathologic Features

Dendritic fibromyxolipoma is a rare and distinctive soft tissue neoplasm that is considered by many authors as a variant of spindle cell lipoma and characterized by the presence of dendritic cytoplasmic processes, plexiform vascular pattern, and keloidal collagen. It has never been reported in the larynx and hypopharynx. Its rarity and the potential to mistake it as a more clinically aggressive myxoid soft tissue neoplasm highlight the importance of its recognition. Here, a case of a dendritic fibromyxolipoma of the pyriform sinus in a 38-year-old male who presented with dysphagia, change of voice, and stridor is reported. A review of the literature, including histopathologic features and differential diagnosis, is also included.

scholarly journals Squamous Lesions of the Ovary

2011 ◽  
Vol 135 (12) ◽  
pp. 1611-1614 ◽  
Author(s):  
Etienne Mahe ◽  
Monalisa Sur
Keyword(s):  
Differential Diagnosis ◽  
Clinical Features ◽  
Review Of The Literature ◽  
Squamous Differentiation ◽  
Prognostic Features ◽  
The Common ◽  
Histopathologic Features

The ovary shows an innate potential for markedly variable histogenesis, including squamous differentiation. Although not uncommon, squamous differentiation in ovarian lesions can be present in several diagnostic contexts, both benign and malignant. We present a review of the literature pertaining to squamous lesions of the ovary. In particular, we summarize the relevant clinical features, workup, gross findings and histopathologic features, differential diagnosis, treatment, and prognostic features of both the common and rare squamous entities found in the ovary.

scholarly journals Diffuse Facial Hyperpigmentation as a Presenting Sign of Lupus Erythematosus: Three Cases and Review of the Literature

2021 ◽  
pp. 263-270
Author(s):  
Shir Azrielant ◽  
Eran Ellenbogen ◽  
Alon Peled ◽  
Valentina Zemser-Werner ◽  
Liat Samuelov ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Lupus Erythematosus ◽  
Autoimmune Disorder ◽  
Patient Evaluation ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Systemic Involvement

Lupus erythematosus (LE) is an autoimmune disorder commonly affecting the skin; cutaneous lesions may indicate systemic involvement, warranting further evaluation. Photosensitivity, which may result in hyperpigmentation, is a well-known feature of the disease. In contrast, the prevalence of primary hyperpigmentation as a presenting sign of LE is not well established. Here, we compare 3 unique cases of diffuse facial hyperpigmentation as the primary manifestation of LE (cutaneous or systemic) and review previously reported cases. Our data highlight the need for considering LE in the differential diagnosis of facial hyperpigmentation and substantiate the importance of this unique lupus variant in early diagnosis and patient evaluation.

scholarly journals Bladder perivascular epithelioid cell neoplasm: The importance of immunohistochemistry in the diagnosis of an unusual neoplasm

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110008
Author(s):  
Solange De Noon ◽  
Benjamin Ayres ◽  
Uday Patel ◽  
Rami Issa ◽  
Colan Maxwell Ho-Yen
Keyword(s):  
Differential Diagnosis ◽  
Epithelioid Cell ◽  
Review Of The Literature ◽  
Histological Features ◽  
Perivascular Epithelioid Cell Neoplasms ◽  
Perivascular Epithelioid Cell ◽  
Organ Systems ◽  
Cell Neoplasm ◽  
Key Features ◽  
Mesenchymal Tumours

Perivascular epithelioid cell neoplasms represent a group of uncommon mesenchymal tumours with as yet undiscovered benign counterpart. Although perivascular epithelioid cell neoplasms have been described arising in most organ systems as well as in soft tissue and bone, only a small number of perivascular epithelioid cell neoplasms have been reported in the bladder. To date, there is no agreed system for predicting the behaviour of these tumours. We describe a case of a perivascular epithelioid cell neoplasm of the bladder arising in a 57-year-old male and initially diagnosed on biopsy and present a review of the literature focussing on the pathological differential diagnosis and the importance of key histological features in conjunction with a broad immunohistochemical panel. This case report highlights the key features of bladder perivascular epithelioid cell neoplasms that distinguishes these rare neoplasms from other bladder lesions.

scholarly journals Belated Diagnosis of a Primary Bone Lymphoma of the Elbow: A Rare Case and Review of the Literature

2020 ◽  
pp. 100-107
Author(s):  
Michele Boffano ◽  
Nicola Ratto ◽  
Martina Rezzoagli ◽  
Andrea Conti ◽  
Pietro Pellegrino ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Rare Case ◽  
Early Stage ◽  
Bone Lesions ◽  
Review Of The Literature ◽  
Primary Bone Lymphoma ◽  
Lytic Bone Lesions ◽  
Primary Bone ◽  
Bone Lymphoma

Primary non-Hodgkin bone lymphoma (PBL) is a rare disease that accounts for <2% of all lymphomas in adults. PBL can be monostotic or polyostotic, mainly causing destructive and lytic bone lesions frequently located in the femur, humerus, and pelvis. PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL is not uncommonly diagnosed with delay because patients do not experience symptoms nor show objective abnormalities in the early stage of disease. Here, we reported a 60-year-old woman with a PBL of the elbow.

Sign in / Sign up

Export Citation Format

Share Document