Atypical Fibroxanthoma Arising in a Scar of Discoid Lupus Erythematosus

2014 ◽  
Vol 18 (5) ◽  
pp. 353-355 ◽  
Author(s):  
Vincenzo De Francesco ◽  
Enzo Errichetti ◽  
Enrico Pegolo ◽  
Giuseppe Stinco
Keyword(s):  
Lupus Erythematosus ◽  
Fibrous Histiocytoma ◽  
Early Stage ◽  
Rare Event ◽  
Soft Tissue Sarcomas ◽  
Squamous Cell Carcinomas ◽  
Discoid Lupus Erythematosus ◽  
Atypical Fibroxanthoma ◽  
Basal Cell Carcinomas

Background: Malignant change in the scars of discoid lupus erythematosus (DLE) is a well-known event. In most cases, tumors are of epithelial origin, particularly squamous cell carcinomas and, less frequently, basal cell carcinomas and keratoacanthomas. The onset of soft tissue sarcomas in a DLE scar is a very rare event, however, because only one case of malignant fibrous histiocytoma has been described in the literature. Objective: We describe the first documented report of atypical fibroxanthoma (AFX) arising in an old scar of DLE. Results: Although we cannot exclude an accidental association between AFX and DLE, our case emphasizes that patients with DLE may develop AFX in the context of an old scar. Conclusion: Our finding further underlines the importance of strict and long-term surveillance of people with DLE to identify and remove eventual tumors at an early stage.

Long-term Results of Intralesional Interferon Alpha-2B in Discoid Lupus Erythematosus

1993 ◽  
Vol 20 (7) ◽  
pp. 444-446 ◽  
Author(s):  
Jesús Martínez ◽  
Ricardo F. de Misa ◽  
Pablo Boixeda ◽  
José María Arrazola ◽  
Antonio Ledo
Keyword(s):  
Interferon Alpha ◽  
Lupus Erythematosus ◽  
Long Term Results ◽  
Discoid Lupus Erythematosus ◽  
Interferon Alpha 2B

Systemic Lupus Erythematosus

2019 ◽  
Author(s):  
Kyriakos A. Kirou ◽  
Michael D. Lockshin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sun Exposure ◽  
Disease Classification ◽  
Discoid Lupus Erythematosus ◽  
Neurologic Disease ◽  
Systemic Lupus ◽  
Nuclear Antigens ◽  
Key Words Systemic Lupus

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune illness characterized by autoantibodies directed at nuclear antigens that cause clinical and laboratory abnormalities, such as rash, arthritis, leukopenia and thrombocytopenia, alopecia, fever, nephritis, and neurologic disease. Most or all of the symptoms of acute lupus are attributable to immunologic attack on the affected organs. Many complications of long-term disease are attributable to both the disease and its treatment. Intense sun exposure, drug reactions, and infections are circumstances that induce flare; the aim of treatment is to induce remission. This chapter is divided into sections dealing with SLE’s definitions; epidemiology; pathogenesis; disease classification, diagnosis, and differential diagnosis; and treatment. This review contains 10 figures, 12 tables, and 97 references. Key Words: Systemic lupus erythematosus, Dermatomyositis, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, Discoid lupus erythematosus, truncal psoriasiform, annular polycyclic rash

Multiple Squamous Cell Carcinomas Arising in Lesions of Discoid Lupus Erythematosus

2004 ◽  
Vol 31 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Shigeto Matsushita ◽  
Tsuyoshi Ishihara ◽  
Toshiro Kageshita ◽  
Kiyofumi Egawa ◽  
Taiga Miyake ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Lupus Erythematosus ◽  
Squamous Cell Carcinomas ◽  
Discoid Lupus Erythematosus

Systemic Lupus Erythematosus

2019 ◽  
Author(s):  
Kyriakos A. Kirou ◽  
Michael D. Lockshin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sun Exposure ◽  
Disease Classification ◽  
Discoid Lupus Erythematosus ◽  
Neurologic Disease ◽  
Systemic Lupus ◽  
Nuclear Antigens ◽  
Key Words Systemic Lupus

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune illness characterized by autoantibodies directed at nuclear antigens that cause clinical and laboratory abnormalities, such as rash, arthritis, leukopenia and thrombocytopenia, alopecia, fever, nephritis, and neurologic disease. Most or all of the symptoms of acute lupus are attributable to immunologic attack on the affected organs. Many complications of long-term disease are attributable to both the disease and its treatment. Intense sun exposure, drug reactions, and infections are circumstances that induce flare; the aim of treatment is to induce remission. This chapter is divided into sections dealing with SLE’s definitions; epidemiology; pathogenesis; disease classification, diagnosis, and differential diagnosis; and treatment. This review contains 10 figures, 12 tables, and 97 references. Key Words: Systemic lupus erythematosus, Dermatomyositis, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, Discoid lupus erythematosus, truncal psoriasiform, annular polycyclic rash

Primary presentation of spontaneous jugular vein thrombosis to the otolaryngologist - in three different pathologies

1998 ◽  
Vol 112 (9) ◽  
pp. 888-890 ◽  
Author(s):  
U. S. Kale ◽  
R. G. Wight
Keyword(s):  
Lupus Erythematosus ◽  
Jugular Vein ◽  
Sinus Thrombosis ◽  
Rare Event ◽  
Discoid Lupus Erythematosus ◽  
Lateral Sinus ◽  
Jugular Vein Thrombosis ◽  
Vein Thrombosis ◽  
Middle Ear Disease ◽  
Primary Presentation

AbstractAn otolaryngologist is conversant with the potential of middle-ear disease leading to lateral sinus thrombosis and subsequent jugular vein thrombosis, although this is becoming an increasingly rare event. Spontaneous jugular vein thrombosis from non-otological causes, however, is not well described in the otolaryngology literature. We present three cases of jugular vein thrombosis who presented primarily to the Otolaryngology department each attributable to a different pathology including discoid lupus erythematosus, antiphospholipid syndrome and metastatic malignancy. Awareness needs to be increased of this condition in the differential diagnosis of acute neck swelling and neck pain.

scholarly journals Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia

2019 ◽  
Vol 6 (1) ◽  
pp. 35-41
Author(s):  
Takashi Iizumi ◽  
Shosei Shimizu ◽  
Haruko Numajiri ◽  
Hideyuki Takei ◽  
Noboru Yamada ◽  
...  
Keyword(s):  
Proton Beam ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Late Toxicity ◽  
Proton Beam Therapy ◽  
Target Lesion ◽  
Limb Amputation ◽  
Local Hyperthermia

Abstract Purpose: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. The standard treatment is adequate surgical resection; in addition, radiation therapy plays a major role in perioperative treatment in most cases. Herein, we report the case of a patient with a large MFH who was successfully treated with combined proton beam therapy (PBT) and local hyperthermia (LH). Case Presentation: A 60-year-old man presented with a 6×4-cm mass on his left thigh. Histopathology and immunohistochemistry indicated MFH, and he refused limb amputation. He received treatment with PBT at a dose at 72 GyE in 18 fractions. To cover the entire large target lesion, we used a patch-field protocol. He also concurrently received 7 courses of LH. The combination therapy achieved long-term local control without severe acute or late toxicity during the 7-year follow-up period. Conclusions: This case suggests that the combination of PBT and LH may be an option as a limb-preserving treatment for large inoperable MFH in the extremities.

Systemic Lupus Erythematosus

2019 ◽  
Author(s):  
Kyriakos A. Kirou ◽  
Michael D. Lockshin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sun Exposure ◽  
Disease Classification ◽  
Discoid Lupus Erythematosus ◽  
Neurologic Disease ◽  
Systemic Lupus ◽  
Nuclear Antigens ◽  
Key Words Systemic Lupus

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune illness characterized by autoantibodies directed at nuclear antigens that cause clinical and laboratory abnormalities, such as rash, arthritis, leukopenia and thrombocytopenia, alopecia, fever, nephritis, and neurologic disease. Most or all of the symptoms of acute lupus are attributable to immunologic attack on the affected organs. Many complications of long-term disease are attributable to both the disease and its treatment. Intense sun exposure, drug reactions, and infections are circumstances that induce flare; the aim of treatment is to induce remission. This chapter is divided into sections dealing with SLE’s definitions; epidemiology; pathogenesis; disease classification, diagnosis, and differential diagnosis; and treatment. This review contains 10 figures, 12 tables, and 97 references. Key Words: Systemic lupus erythematosus, Dermatomyositis, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, Discoid lupus erythematosus, truncal psoriasiform, annular polycyclic rash

Atypical Fibroxanthoma

2001 ◽  
Vol 110 (10) ◽  
pp. 985-987 ◽  
Author(s):  
Ishrat Hakim
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Soft Tissue ◽  
Wide Local Excision ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Dermatofibrosarcoma Protuberans ◽  
Tissue Preservation ◽  
Atypical Fibroxanthoma ◽  
First Case

This is the first case report of atypical fibroxanthoma in the otolaryngology literature. Atypical fibroxanthoma is a rare fibrohistiocytic tumor that occurs on actinically damaged skin. The typical presentation is a nodular lesion in sun-exposed areas of the head and neck in an elderly patient. Differentiating atypical fibroxanthoma from other soft tissue sarcomas, such as dermatofibrosarcoma protuberans and malignant fibrous histiocytoma, can be difficult. Treatment should be wide local excision with a 1-cm margin. In cosmetically important regions in which tissue preservation is important, Mohs' surgery should be considered.

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