scholarly journals Bonelike Apatite Coating on Skeleton of Poly(lactic acid) Composite Sponge

2004 ◽  
Vol 45 (4) ◽  
pp. 989-993 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
2005 ◽  
Vol 284-286 ◽  
pp. 301-304 ◽  
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.


2007 ◽  
Vol 334-335 ◽  
pp. 1213-1216 ◽  
Author(s):  
Yun Chen ◽  
Arthur F.T. Mak ◽  
Min Wang

Bonelike apatite coating was formed on poly(L-lactic acid) (PLLA) scaffolds and poly(glycolic acid) (PGA) scaffolds in 24 hours through an accelerated biomimetic process. The ion concentrations in the simulated body fluid (SBF) were nearly 5 times of those in human blood plasma. The apatite formed in 5SBF was similar in morphology and composition to that formed in the classical biomimetic process employing SBF or 1.5SBF, and similar to that of natural bone. To facilitate coating into scaffolds, the flowing condition was introduced into the accelerated biomimetic process. It was found that the accelerated biomimetic process performed in the flowing condition yielded more uniform spatial distribution of apatite particles than that in the regular shaking condition.


2007 ◽  
Vol 330-332 ◽  
pp. 519-522
Author(s):  
Akiko Obata ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga

2011 ◽  
Vol 131 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Toru Oi ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita

2014 ◽  
Vol 134 (4) ◽  
pp. 237-242
Author(s):  
Naru Matsugasaki ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita

2020 ◽  
Vol 62 (6) ◽  
pp. 732-743
Author(s):  
Chi-Hui Tsou ◽  
Jipeng Guo ◽  
Ji-Ang Lei ◽  
Manuel Reyes De Guzman ◽  
Maw-Cherng Suen
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