Islet Beta-Cell Specific Deletion of UBL5 Gene Associated with Mitochondrial Stress Leads to Diabetes in Mice and Beta-Cell Impairment/Death

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 311-LB
Author(s):  
CHRISTIAN HARALAMBOUS ◽  
VIKTORIA NTOUMA
Keyword(s):  
Beta Cell ◽  
Mitochondrial Stress ◽  
Islet Beta Cell ◽  
Diabetes In Mice ◽  
Specific Deletion

2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2129-P
Author(s):  
YUTING LU ◽  
JINGYA LI ◽  
JIA LI
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Islet Beta Cell

2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2116-P
Author(s):  
JEEYEON CHA ◽  
EMILY M. WALKER ◽  
XIN TONG ◽  
MIN GUO ◽  
JIN HUA LIU ◽  
...  
Keyword(s):  
Beta Cell ◽  
Missense Mutation ◽  
Cell Aging ◽  
Islet Beta Cell

scholarly journals Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

Diabetologia ◽  
2010 ◽  
Vol 53 (6) ◽  
pp. 1046-1056 ◽  
Author(s):  
S. Zraika ◽  
R. L. Hull ◽  
C. B. Verchere ◽  
A. Clark ◽  
K. J. Potter ◽  
...  
Keyword(s):  
Cell Death ◽  
Beta Cell ◽  
Circumstantial Evidence ◽  
Beta Cell Death ◽  
Islet Beta Cell

scholarly journals Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients

Diabetologia ◽  
1994 ◽  
Vol 37 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Y. Tanizawa ◽  
A. C. Riggs ◽  
J. M. Roseman ◽  
M. A. Permutt ◽  
K. C. Chiu ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
Glucose Transporter ◽  
Transporter Gene ◽  
Islet Beta Cell ◽  
Pancreatic Islet Beta Cell ◽  
Niddm Patients

scholarly journals Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose

2020 ◽  
Vol 64 (4) ◽  
pp. 235-248 ◽  
Author(s):  
Karin J Bosma ◽  
Mohsin Rahim ◽  
Kritika Singh ◽  
Slavina B Goleva ◽  
Martha L Wall ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Fasting Blood Glucose ◽  
Human Islets ◽  
Peripheral Tissues ◽  
Adult Mice ◽  
Mouse Islets ◽  
Glucose Stimulated Insulin Secretion ◽  
Pancreatic Islet Beta Cell ◽  
Specific Deletion

The G6PC1, G6PC2 and G6PC3 genes encode distinct glucose-6-phosphatase catalytic subunit (G6PC) isoforms. In mice, germline deletion of G6pc2 lowers fasting blood glucose (FBG) without affecting fasting plasma insulin (FPI) while, in isolated islets, glucose-6-phosphatase activity and glucose cycling are abolished and glucose-stimulated insulin secretion (GSIS) is enhanced at submaximal but not high glucose. These observations are all consistent with a model in which G6PC2 regulates the sensitivity of GSIS to glucose by opposing the action of glucokinase. G6PC2 is highly expressed in human and mouse islet beta cells however, various studies have shown trace G6PC2 expression in multiple tissues raising the possibility that G6PC2 also affects FBG through non-islet cell actions. Using real-time PCR we show here that expression of G6pc1 and/or G6pc3 are much greater than G6pc2 in peripheral tissues, whereas G6pc2 expression is much higher than G6pc3 in both pancreas and islets with G6pc1 expression not detected. In adult mice, beta cell-specific deletion of G6pc2 was sufficient to reduce FBG without changing FPI. In addition, electronic health record-derived phenotype analyses showed no association between G6PC2 expression and phenotypes clearly unrelated to islet function in humans. Finally, we show that germline G6pc2 deletion enhances glycolysis in mouse islets and that glucose cycling can also be detected in human islets. These observations are all consistent with a mechanism by which G6PC2 action in islets is sufficient to regulate the sensitivity of GSIS to glucose and hence influence FBG without affecting FPI.

scholarly journals Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.

1990 ◽  
Vol 9 (1) ◽  
pp. 53-60 ◽  
Author(s):  
W.F. Pralong ◽  
C. Bartley ◽  
C.B. Wollheim
Keyword(s):  
Beta Cell ◽  
Pyridine Nucleotides ◽  
Cell Stimulation ◽  
Islet Beta Cell

Pancreatic Islet Beta-Cell Replacement Strategies

2020 ◽  
pp. 193-214
Author(s):  
J. Jason Collier ◽  
Susan J. Burke
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
Cell Replacement ◽  
Islet Beta Cell ◽  
Beta Cell Replacement ◽  
Pancreatic Islet Beta Cell
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