1663-P: Monophasic Glucose Response Curve Reflective of Glucose Intolerance in Young Mexican Americans

Diuretic-induced glucose intolerance is cited frequently as a problem of only limited clinical significance. In certain populations, such as Mexican-Americans, this effect may be much more dramatic. A 50-year-old obese Mexican-American woman presented with a three-month history of increased thirst and frequent urination. A fasting blood glucose concentration of 365 mg/dL prompted initiation of chlorpropamide therapy. A review of her medical history revealed that a thiazide diuretic was started six months previously. A reduction in thiazide dose and potassium supplementation together with chlorpropamide therapy controlled the patient's blood glucose. Subsequently, all three medications were discontinued, and the patient remained normoglycemic during a full year of follow-up. The temporal relationship between symptomatic diabetes and hydrochlorothiazide therapy incriminates the diuretic as the most probable cause.

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The shape of the glucose response curve during an OGTT heralds β−cell function in a large Chinese population

10.21203/rs.2.11308/v2 ◽

2019 ◽

Author(s):

Xinqi Cheng ◽

Na Yang ◽

Yuxiu Li ◽

Qi Sun ◽

Ling Qiu ◽

...

Keyword(s):

Insulin Resistance ◽

Chinese Population ◽

Response Curve ◽

Cell Function ◽

Serum Insulin ◽

Oral Glucose ◽

Insulinogenic Index ◽

Β Cell ◽

Glucose Response ◽

Β Cell Function

Abstract Background The shape of the glucose response during an oral glucose tolerance test can detect β-cell function and insulin resistance. But there were few studies in Chinese, so we aimed to verify the utility of these connections in a large Chinese population. Methods A total of 11,866 times of 3-h OGTT were categorized to either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, Matsuda index, insulinogenic index and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT. Results Individuals with a monophasic shape had significantly higher glucose, insulin, and had significantly lower insulin sensitivity and impaired β-cell function than multiphasic group. In addition, Individuals were younger with a multiphasic shape compared to those with a monophasic shape. Conclusion The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

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Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men

Journal of Diabetes Investigation ◽

10.1111/jdi.13227 ◽

2020 ◽

Vol 11 (4) ◽

pp. 874-877

Author(s):

Hideyoshi Kaga ◽

Yoshifumi Tamura ◽

Kageumi Takeno ◽

Saori Kakehi ◽

Yuki Someya ◽

...

Keyword(s):

Insulin Sensitivity ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Response Curve ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Insulin Clearance ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Glucose Response

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Use of sourdough lactobacilli and oat fibre to decrease the glycaemic index of white wheat bread

British Journal Of Nutrition ◽

10.1017/s0007114507772689 ◽

2007 ◽

Vol 98 (6) ◽

pp. 1196-1205 ◽

Cited By ~ 56

Author(s):

Maria De Angelis ◽

Carlo G. Rizzello ◽

Giuditta Alfonsi ◽

Philip Arnault ◽

Stefan Cappelle ◽

...

Keyword(s):

Lactic Acid ◽

Resistant Starch ◽

Specific Volume ◽

Response Curve ◽

Lactobacillus Brevis ◽

Glycaemic Index ◽

Wheat Bread ◽

Glucose Response ◽

White Wheat ◽

Crumb Structure

This work was aimed at decreasing the glycaemic index (GI) of white wheat bread. Breads made with wheat flour (WF) or wholemeal flour (WMF) and fermented with baker's yeast had similar values of resistant starch (RS; 1·4–1·7 %, starch basis). Sourdough Lactobacillus plantarum P1 and Lactobacillus brevis P2 favoured the highest formation of RS (approximately 5 %) when fermented with WF and WMF. The mixture (1:1) of WF and WMF (WF/WMF) was selected. The effect of dietary fibres, chemical or sourdough acidification on the hydrolysis index (HI) of WF/WMF bread was determined. Among fibres, only the addition of oat fibre (5 %) decreased the HI to 90·84 %. Lactic acid determined the lowest HI, and the effect was related to the decrease of pH. For the same decrease of pH, breads fermented with L. plantarum P1 and L. brevis P2 (sourdough WF/WMF) showed values of HI lower than chemical acidification. The glucose response and GI of WF bread or sourdough WF/WMF bread enriched with oat fibre was determined by using fifteen healthy volunteers. Anhydrous glucose was used as reference. The area under the glucose response curve and the value of GI (72 %) of WF bread were significantly (P < 0·05) higher than sourdough WF/WMF bread enriched with oat fibre (GI = 53·7 %). The decrease of GI of the sourdough WF/WMF bread may be due to both fibre content and decreased pH. Compared to WMF bread, sourdough WF/WMF bread, enriched with oat fibre, had higher specific volume, better cell crumb structure and more appreciated acidulous smell, taste and aroma.

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The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth

Diabetes Care ◽

10.2337/dc16-0352 ◽

2016 ◽

Vol 39 (8) ◽

pp. 1431-1439 ◽

Cited By ~ 34

Author(s):

Joon Young Kim ◽

Sara F. Michaliszyn ◽

Alexis Nasr ◽

SoJung Lee ◽

Hala Tfayli ◽

...

Keyword(s):

Type 2 Diabetes ◽

Glucose Tolerance ◽

Response Curve ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Glucose Response ◽

Obese Youth

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Glucose Response Curve and Type 2 Diabetes Risk in Latino Adolescents

Diabetes Care ◽

10.2337/dc11-2476 ◽

2012 ◽

Vol 35 (9) ◽

pp. 1925-1930 ◽

Cited By ~ 38

Author(s):

J. Y. Kim ◽

D. K. Coletta ◽

L. J. Mandarino ◽

G. Q. Shaibi

Keyword(s):

Type 2 Diabetes ◽

Response Curve ◽

Diabetes Risk ◽

Latino Adolescents ◽

Glucose Response

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The shape of the glucose response curve during an OGTT heralds β−cell function in a large Chinese population

10.21203/rs.2.11308/v1 ◽

2019 ◽

Author(s):

Xinqi Cheng ◽

Na Yang ◽

Yuxiu Li ◽

Qi Sun ◽

Ling Qiu ◽

...

Keyword(s):

Insulin Resistance ◽

Chinese Population ◽

Response Curve ◽

Cell Function ◽

Serum Insulin ◽

Oral Glucose ◽

Insulinogenic Index ◽

Β Cell ◽

Glucose Response ◽

Β Cell Function

Abstract Background The shape of the glucose response during an oral glucose tolerance test can detect β-cell function and insulin resistance. But there were few studies in Chinese, so we aimed to verify the utility of these connections in a large Chinese population. Methods A total of 11,866 times of 3-h OGTT were categorized to either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, Matsuda index, insulinogenic index and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT. Results Individuals with a monophasic shape had significantly higher glucose, insulin, and had significantly lower insulin sensitivity and impaired β-cell function than multiphasic group. In addition, Individuals were younger with a multiphasic shape compared to those with a monophasic shape. Conclusion The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

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