2430-PUB: Analysis of Transient Elastography Data and the Risk of Metabolic Syndrome

(1) Background: Direct-acting antiviral therapy for chronic hepatitis C virus (HCV) infection is associated with high sustained virologic response (SVR) and overcomes negative predictive factors, including steatosis, in patients without human immunodeficiency virus (HIV) coinfection. The impact of steatosis on SVR in patients with HIV–HCV coinfection is unknown. (2) Methods: A retrospective analysis of patients treated with direct-acting antivirals was performed. Demographic, laboratory and direct-acting antiviral regimen data were prospectively collected. Metabolic syndrome and its components—diabetes mellitus, hypertension, dyslipidemia and obesity—were assessed. Hepatic steatosis (≥5%) was defined by liver biopsy or controlled attenuation parameter (CAP) measurement during vibration-controlled transient elastography (VCTE). (3) Results: A total of 151 HIV–HCV-coinfected patients on combined antiretroviral therapy and direct-acting antiviral therapy were included in this analysis. Prevalence of steatosis by liver biopsy (n = 34) or CAP (≥263 db/m) during VCTE (n = 92) was 27% and was independently associated with obesity (OR 3.11; 95% CI 1.43–6.82; p = 0.004) and the metabolic syndrome (OR 1.08; 95% CI 1.01–0.15; p = 0.01). The overall SVR rate (n = 148) was 95% and was not impacted by the presence of steatosis (p = 0.42). (4) Conclusions: Hepatic steatosis is common in HIV–HCV coinfection, correlates with obesity and the metabolic syndrome and does not impact SVR.

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High liver stiffness values by transient elastography related to metabolic syndrome and harmful alcohol use in a large Spanish cohort

United European Gastroenterology Journal ◽

10.1002/ueg2.12109 ◽

2021 ◽

Author(s):

Elba Llop ◽

Paula Iruzubieta ◽

Christie Perelló ◽

Carlos Fernández Carrillo ◽

Joaquín Cabezas ◽

...

Keyword(s):

Metabolic Syndrome ◽

Alcohol Use ◽

Transient Elastography ◽

Liver Stiffness ◽

Harmful Alcohol ◽

Spanish Cohort ◽

High Liver

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Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?

BioMed Research International ◽

10.1155/2016/7963972 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Jamrus Pongpit ◽

Saneerat Porntharukchareon ◽

Piyaporn Kaewduang ◽

Kwannapa Promson ◽

Wasana Stitchantrakul ◽

...

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Liver Fibrosis ◽

Associated Factors ◽

Transient Elastography ◽

Liver Stiffness ◽

Liver Stiffness Measurement ◽

Nonalcoholic Fatty Liver ◽

Stiffness Measurement ◽

Significant Liver Fibrosis

Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients. Methods. Subjects underwent TE and ultrasonography. Univariate and multivariate analysis were performed for the associated factors. Results. One hundred and sixty-eight patients were recruited. Three patients were excluded due to TE failure. Mean BMI was 24.8±4.7 kg/m2. NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients. The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients. Mean LSM was 5.3±2.9 kPa. High LSM was found in 18 (11.0%) patients. Waist circumference (OR: 1.24; 95% CI: 1.11–1.38; P=0.0002), diabetes (OR: 12.70; 95% CI: 1.84–87.70; P=0.010), and AST (OR: 1.08; 95% CI: 1.02–1.16; P=0.017) were associated with high LSM. Conclusion. 11% of psoriatic patients had significant liver fibrosis by high LSM. Waist circumference, diabetes, and AST level were the independent predictors.

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