Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome

The metabolic syndrome is a clinical situation including a series of factors at high cardiovascular risk; the treatment with an oxygenozone gas mixture can influence all factors associated with this syndrome. The objective of the study has been to verify if the rectal insufflation could replace the large auto-hemoinfusion when treating the metabolic syndrome in those patients who, for various reasons cannot use the auto-hemoinfusion. Twenty-four individuals aged between 34 and 68 were recruited and included in the group treated with ozonated auto-hemoinfusion and other 24 individuals aged between 35 and 67 were recruited and included in the group treated with rectal insufflation of the oxygen-ozone gas mixture. According to the results obtained by means of oxygen-ozone mixture rectal insufflation, which are almost equivalent to the results obtained with the large ozonated auto-hemoinfusion, authors could conclude that the ozonated rectal insufflation can be taken into consideration as alternative method to the large auto-hemoinfusion, while treating the metabolic syndrome, in those patients difficult to manage due to the previously described reasons.

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Factors associated with the metabolic syndrome in a national sample of youths: CASPIAN Study

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2007.02.014 ◽

2008 ◽

Vol 18 (7) ◽

pp. 461-470 ◽

Cited By ~ 53

Author(s):

Roya Kelishadi ◽

Mohammad Mehdi Gouya ◽

Khosrow Adeli ◽

Gelayol Ardalan ◽

Riaz Gheiratmand ◽

...

Keyword(s):

Metabolic Syndrome ◽

National Sample ◽

Factors Associated ◽

The Metabolic Syndrome

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Prevalence and factors associated with Metabolic Syndrome in elderly users of the Unified Health System

Revista Brasileira de Epidemiologia ◽

10.1590/1809-4503201400040001 ◽

2014 ◽

Vol 17 (4) ◽

pp. 805-817 ◽

Cited By ~ 10

Author(s):

Edna Cunha Vieira ◽

Maria do Rosário Gondim Peixoto ◽

Erika Aparecida da Silveira

Keyword(s):

Metabolic Syndrome ◽

Health System ◽

Health Workers ◽

The Elderly ◽

World Health ◽

Fat Percentage ◽

Cross Sectional ◽

Factors Associated ◽

Unified Health System ◽

The Metabolic Syndrome

OBJECTIVE: To evaluate the prevalence and factors associated with metabolic syndrome in the elderly. METHODS: Cross-sectional study, with 133 individuals randomly selected in the Unified Health System in Goiania, Goiás. The following variables were researched: anthropometric (BMI, waist circumference, fat percentage by Dual X-ray absorptiometry), sociodemographic (gender, age, color, income, marital status and years of schooling), lifestyle (physical activity, smoking and risk alcohol consumption) and food intake (risk and protective foods). The metabolic syndrome was assessed according to harmonized criteria proposed by the World Health Organization (WHO). The combinations were tested by Poisson regression for confounding factors. RESULTS: The prevalence of metabolic syndrome was 58.65% (95%CI 49.8 - 67.1), with 60.5% (95%CI 49.01 - 71.18) for females and 55.7% (95%CI 41.33 - 69.53) for males. Hypertension was the most prevalent component of the syndrome in both men, with 80.8% (95%CI 64.5 - 90.4), and women, with 85.2% (95%CI 75.5 - 92.1). After the multivariate analysis, only the excess of weight measured by body mass index (prevalence ratio = 1.66; p < 0.01) remained associated with the metabolic syndrome. CONCLUSIONS: The prevalence of metabolic syndrome in this sample was high, indicating the need for systematic actions by health workers in the control of risk factors through prevention strategies and comprehensive care to the elderly.

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Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study

Pain ◽

10.1016/j.pain.2013.04.043 ◽

2013 ◽

Vol 154 (9) ◽

pp. 1595-1602 ◽

Cited By ~ 35

Author(s):

Nicola J. Goodson ◽

Blair H. Smith ◽

Lynne J. Hocking ◽

Mark M. McGilchrist ◽

Anna F. Dominiczak ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Chronic Pain ◽

Cardiovascular Risk ◽

General Population ◽

Cardiovascular Risk Factors ◽

Cross Sectional ◽

General Population Study ◽

Factors Associated ◽

The Metabolic Syndrome

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Abstract 1186: Overexpression Of Endothelial Lipase In The Liver Promotes The Clearance Of Plasma Lipids But Accelerates Liver Steatosis In A Mouse Model Of Metabolic Syndrome

Circulation ◽

10.1161/circ.116.suppl_16.ii_240 ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Tomoyuki Yasuda ◽

Tatsuro Ishida ◽

Yoko Kojima ◽

Hanayo Tanaka ◽

Takeaki Okada ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Acid ◽

Mouse Model ◽

Fatty Acid Synthase ◽

Plasma Lipids ◽

Recombinant Adenovirus ◽

Mrna Level ◽

Liver Steatosis ◽

Endothelial Lipase ◽

The Metabolic Syndrome

The metabolic syndrome includes high triglyceride (TG) and low HDL-cholesterol (HDL-C) levels in the plasma, and often accompanies steatosis in the liver. Endothelial lipase (EL) is a phospholipase that regulates HDL metabolism. EL is expressed by hepatocytes, while the function of EL in the liver has not been identified. Here, we examined the role of EL in the liver using a mouse model of metabolic syndrome. The EL expression in the liver was analyzed by real-time PCR. It revealed that liver EL expression was significantly increased in obese and diabetic db/db mice compared to that of control mice. To examine the significance of the EL upregulation in the liver, we injected the recombinant adenovirus encoding human EL into mice. The EL overexpression in the liver resulted in a significant decrease in plasma HDL-C, TG, and free fatty acid levels. Interestingly, the EL overexpression in the liver increased liver weight and liver TG content both in wild-type and db/db mice. In db/db mice, particularly, EL overexression accelerated the formation of steatosis by increasing the mRNA level of fatty acid synthase. These findings indicate that EL expression is increased in the liver in the metabolic syndrome. The upregulation of EL promotes the uptake of plasma lipids by hepatocytes, and accelerates the progression of steatosis in db/db mice. Thus EL may play a role in the genesis of steatosis as well as dyslipidemia in the metabolic syndrome.

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Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome

The Journal of Lipid Research ◽

10.1194/jlr.p900033-jlr200 ◽

2009 ◽

Vol 50 (9) ◽

pp. 1917-1926 ◽

Cited By ~ 75

Author(s):

Sonya J. Elder ◽

Alice H. Lichtenstein ◽

Anastassios G. Pittas ◽

Susan B. Roberts ◽

Paul J. Fuss ◽

...

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Environmental Influences ◽

Factors Associated ◽

The Metabolic Syndrome

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Interventions for metabolic problems in people with schizophrenia

10.1093/med/9780198811688.003.0008 ◽

2017 ◽

Author(s):

David J. Castle ◽

Peter F. Buckley ◽

Fiona P. Gaughran

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Physical Health ◽

Early Death ◽

Effective Communication ◽

Self Management ◽

Antipsychotic Medications ◽

Factors Associated ◽

The Metabolic Syndrome ◽

Comprehensive Framework

To address the risk factors associated with early death in people with schizophrenia, a comprehensive framework is required. This is required to address individuals, systems, and the community. A number of specific frameworks are available to provide better physical health treatments for people with schizophrenia. The most effective of these embrace elements of self-management and self-efficacy. The engagement of patients, carers, and clinicians requires concerted work and effective communication. Peer workers can play a particular role. Various medications can also be used to address specific aspects of the metabolic syndrome in particular, and care should be taken to try to choose (where feasible) antipsychotic medications with the lowest possible risk of metabolic syndrome.

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