525-P: Integrated Mirnome and Proteomic Analyses in Plasma and Progression to ESRD in Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 525-P
Author(s):  
EIICHIRO SATAKE ◽  
JAN SKUPIEN ◽  
ZAIPUL I. MD DOM ◽  
HIROKI KOBAYASHI ◽  
KATSUHITO IHARA ◽  
...  
Keyword(s):  
Proteomic Analyses

Proteomic Analyses of Nipple Fluids for Early Detection of Breast Cancer

2004 ◽  
Author(s):  
Frederick P. Li ◽  
Anne-Renee Hartman ◽  
Alexander Miron
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Proteomic Analyses

scholarly journals Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

2012 ◽  
Vol 11 (12) ◽  
pp. 1578-1585 ◽  
Author(s):  
Sebastian A. Wagner ◽  
Petra Beli ◽  
Brian T. Weinert ◽  
Christian Schölz ◽  
Christian D. Kelstrup ◽  
...  
Keyword(s):  
Proteomic Analyses

Development of a C12Im-Cl-assisted method for rapid sample preparation in proteomic application

2021 ◽  
Author(s):  
Chang Liu ◽  
Xiaoxia Si ◽  
Shumei Yan ◽  
Xinyuan Zhao ◽  
Xiaohong Qian ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Protein Extraction ◽  
Sample Processing ◽  
Processing Methods ◽  
Proteomic Analyses

Chromatography and mass spectrometry (MS) techniques have greatly improved the power of proteomic analyses. However, sample processing methods, including protein extraction and digestion, before MS remain as bottlenecks in the...

scholarly journals Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Christina Coughlan ◽  
Douglas I. Walker ◽  
Kelly M. Lohr ◽  
Jason R. Richardson ◽  
Laura M. Saba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Cytoskeletal Proteins ◽  
Synaptic Function ◽  
Behavioral Alterations ◽  
Mechanisms Of Toxicity ◽  
Kegg Pathways ◽  
Increased Risk ◽  
Proteomic Analyses

Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson’s disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigrostriatal dopamine system in PD and pesticide exposure. Enhanced oxidative stress leads to lipid peroxidation and production of reactive aldehydes; therefore, we conducted proteomic analyses to identify carbonylated proteins in the striatum and cortex of pesticide-treated mice in order to elucidate possible mechanisms of toxicity. Male C57BL/6J mice were treated biweekly for 6 weeks with saline, PQ (10 mg/kg), MB (30 mg/kg), or the combination of PQ and MB (PQMB). Treatments resulted in significant behavioral alterations in all treated mice and depleted striatal dopamine in PQMB mice. Distinct differences in 4-hydroxynonenal-modified proteins were observed in the striatum and cortex. Proteomic analyses identified carbonylated proteins and peptides from the cortex and striatum, and pathway analyses revealed significant enrichment in a variety of KEGG pathways. Further analysis showed enrichment in proteins of the actin cytoskeleton in treated samples, but not in saline controls. These data indicate that treatment-related effects on cytoskeletal proteins could alter proper synaptic function, thereby resulting in impaired neuronal function and even neurodegeneration.

Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains

2014 ◽  
Vol 98 (11) ◽  
pp. 5105-5115 ◽  
Author(s):  
Yu-Sin Jang ◽  
Mee-Jung Han ◽  
Joungmin Lee ◽  
Jung Ae Im ◽  
Yu Hyun Lee ◽  
...  
Keyword(s):  
Phase Transition ◽  
Clostridium Acetobutylicum ◽  
Proteomic Analyses
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