<i>Objective:</i> <a>To investigate the
effect of acute hyperglycemia on brain function in adolescents with type 1
diabetes.</a>
<p><i><br></i></p><p><i>Research Design and Methods:</i><b> </b>Twenty participants with type 1 diabetes (T1D) (age
14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed
two functional magnetic resonance imaging sessions. Participants with T1D
performed the first scanning session under euglycemic and the second under
hyperglycemic clamp (20 mmol/L (360 mg/dL)).<b> </b></p>
<p><i><br></i></p><p><i>Results:</i> Lower spatial working memory (sWM)
capacity during acute hyperglycemia and significant differences in activation
of regions of interest during different stages of the spatial working memory task
(p=0.014) were observed.<b> </b><b></b></p>
<p><i><br></i></p><p><i>Conclusions</i>: Acute hyperglycemia
negatively affected sWM capacity in adolescents with T1D, which is relevant for
daily functioning and academic performance.</p>
<i>Objective:</i> <a>To investigate the
effect of acute hyperglycemia on brain function in adolescents with type 1
diabetes.</a>
<p><i><br></i></p><p><i>Research Design and Methods:</i><b> </b>Twenty participants with type 1 diabetes (T1D) (age
14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed
two functional magnetic resonance imaging sessions. Participants with T1D
performed the first scanning session under euglycemic and the second under
hyperglycemic clamp (20 mmol/L (360 mg/dL)).<b> </b></p>
<p><i><br></i></p><p><i>Results:</i> Lower spatial working memory (sWM)
capacity during acute hyperglycemia and significant differences in activation
of regions of interest during different stages of the spatial working memory task
(p=0.014) were observed.<b> </b><b></b></p>
<p><i><br></i></p><p><i>Conclusions</i>: Acute hyperglycemia
negatively affected sWM capacity in adolescents with T1D, which is relevant for
daily functioning and academic performance.</p>