2074-P: Histone Deacetylase Inhibitors Improve Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2074-P
Author(s):  
CHIH-CHUN LEE ◽  
TATSUYOSHI KONO ◽  
STACI A. WEAVER ◽  
PAUL SOHN ◽  
CARMELLA EVANS-MOLINA
Keyword(s):  
Insulin Secretion ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Calcium Entry ◽  
Store Operated Calcium Entry ◽  
Glucose Stimulated Insulin Secretion

scholarly journals Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2293-2304 ◽  
Author(s):  
Tatsuyoshi Kono ◽  
Xin Tong ◽  
Solaema Taleb ◽  
Robert N. Bone ◽  
Hitoshi Iida ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Insulin Secretion ◽  
Endoplasmic Reticulum Stress ◽  
Calcium Entry ◽  
Β Cell ◽  
Store Operated Calcium Entry

Synchronized Microfluidic System to Dynamically Assess Pancreatic Islet Function beyond Glucose-Stimulated Insulin Secretion

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2162-P
Author(s):  
STEPHAN NIEUWOUDT ◽  
RUTH MCDOWELL ◽  
HUI ZHANG ◽  
JOHN P. KIRWAN
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islet ◽  
Microfluidic System ◽  
Islet Function ◽  
Glucose Stimulated Insulin Secretion
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