<b>Objective</b>: To
describe Celiac Disease (CD) screening rates and glycemic outcomes of a
gluten-free diet (GFD) in type 1 diabetes patients asymptomatic for CD.
<p><b>Research Design
and Methods</b>: Asymptomatic patients (8-45
years) were screened for CD. Biopsy-confirmed CD participants were
randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c
and continuous glucose monitoring (CGM) over 12 months. </p>
<p><b>Results</b>: Adults had higher CD-seropositivity rates than children (6.8%,
95%CI 4.9% to 8.2%, N=1298 vs. 4.7%; 95%CI 3.4% to 5.9%, N=1089, p=0.035) with
lower rates of prior CD-screening (6.9% vs 44.2%, p<0.0001). 51 participants
were randomized to a GFD (N=27) or GCD (N=24). No HbA1c differences were seen between groups (+0.14%,
1.5mmol/mol; 95%CI: -0.79 to 1.08; p=0.76) although greater post-prandial
glucose increases (4-hr +1.5mmol/L; 95%CI:
0.4 to 2.7; p=0.014) emerged with a GFD.</p>
<p><b>Conclusions</b>: CD is
frequently observed in asymptomatic patients with type 1 diabetes and clinical
vigilance is warranted with initiation of a GFD. </p>