scholarly journals Bacterial Load Predicts Healing Rate in Neuropathic Diabetic Foot Ulcers

Diabetes Care ◽  
2007 ◽  
Vol 30 (2) ◽  
pp. 378-380 ◽  
Author(s):  
L. Xu ◽  
S. V. McLennan ◽  
L. Lo ◽  
A. Natfaji ◽  
T. Bolton ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Healing Rate ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

Retrospective Matched Case-Control Study on the Use of CO2 Laser for the Treatment of Nonhealing Diabetic Foot Ulcers: The DULCIS-2 (Diabetic ULcer, CO2 Laser, and Infections) Study

2020 ◽  
pp. 153473462096029
Author(s):  
Matteo Monami ◽  
Benedetta Ragghianti ◽  
Antonio Silverii ◽  
Alessia Scatena ◽  
Letizia Landi ◽  
...  
Keyword(s):  
Co2 Laser ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Negative Impact ◽  
Bacterial Load ◽  
Case Control ◽  
Foot Ulcers ◽  
Surgical Approaches ◽  
Diabetic Foot Ulcers ◽  
Diabetic Ulcer

Purpose Infection, which is one of the possible complications of diabetic foot ulcers (DFUs), makes the treatment of ulcers challenging because of its negative impact on healing processes and the high prevalence of multiresistant germs. This study is aimed at verifying the effect of a surgical CO2 laser (which reduces the bacterial load and allows a more accurate debridement), as compared with the traditional lancets, on the healing rate of DFU. Methods The present case-control retrospective analysis was performed on patients with chronic (>6 months) DFU with Texas grade >1, treated with 80 W surgical CO2 laser (DEKA SmartXide2 C80, El.En. Group) and compared with a matched sample of patients with similar characteristics, who were treated with a traditional surgical approach. The debridement was performed trying to achieve the complete removal of nonviable tissues. The principal endpoint was the proportion of patients healed at 6 months. All analyses were carried out with SPSS 25.0. The study protocol was approved by the local ethical committee. Results This study included 118 patients (59 cases and 59 controls). At 6 months, the proportion of healing patients was 35% and 18% in cases and controls, respectively ( P = .034). The corresponding figure at 1 year was 62% and 38% ( P = .009), whereas no difference was observed at 1, 2, and 3 months. No serious adverse event was observed. Conclusions In this article, we show for the first time that CO2 laser treatment, in comparison with traditional surgical approaches, can be associated with an increased healing rate in patients with DFU.

scholarly journals Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

2021 ◽  
pp. 1-4
Author(s):  
Astasio Picado Álvaro ◽  
Keyword(s):  
Negative Pressure ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Negative Pressure Therapy ◽  
Novel Therapy ◽  
Pressure Therapy ◽  
Advanced Therapy ◽  
Global Increase

The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

scholarly journals HEALING RATE IN DIABETIC FOOT ULCERS TREATED WITH BIOMEMBRANE AND HYDROCOLLOID POWDER: RANDOMIZED CLINICAL TRIAL

2021 ◽  
Author(s):  
Manuela de Mendonça Figueirêdo Coelho ◽  
Luciana Catunda Gomes de Menezes ◽  
Shérida Karanini Paz de Oliveira ◽  
Ana Débora Alcantara Coêlho Bonfim ◽  
Viviane Mamede Vasconcelos Cavalcante ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Foot Ulcers ◽  
Calotropis Procera ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Diabetic Foot Ulcers ◽  
Clinical Trial Registry ◽  
Experimental Group

Objective: to evaluate the rate of healing in diabetic foot ulcers treated with a biomembrane of latex proteins from Calotropis procera (BioMem CpLP) when compared to powdered hydrocolloid. Method: randomized controlled clinical trial, registered by the Brazilian Clinical Trial Registry (REBEC), according to protocol RBR-98f3j9, carried out with eight people with diabetic foot, in a diabetic foot clinic, from March to July 2019. In the experimental group (n = 04), biomembrane was applied; in the control group (n = 04), hydrocolloid powder was used. The healing rate was assessed at 30 and 60 days after starting treatment. Results: no statistical differences were found between the healing rates of the control group and the experimental group in the temporal analysis of the initial 30 days (p = 0.726) and in the 60 days following the start of treatment (p = 0.562). Conclusion: BioMem CpLP presented healing rates similar to the conventional product, being an effective and low cost alternative for the treatment of diabetic feet.

scholarly journals Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Liling Zhao ◽  
Zi Guo ◽  
Ke Chen ◽  
Wenjun Yang ◽  
Xinxing Wan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Cell Injection ◽  
Endothelial Colony Forming Cells

Background. This study is aimed at investigating the effect of combined transplantation of umbilical cord mesenchymal stem cells (UCMSCs) and umbilical cord blood-derived endothelial colony-forming cells (ECFCs) on diabetic foot ulcer healing and at providing a novel therapy for chronic diabetic foot ulcer. Methods. We reported the treatment of refractory diabetic foot ulcers in twelve patients. Among them, five patients had two or more wounds; thus, one wound in the same patient was treated with cell injection, and other wounds were regarded as self-controls. The remaining seven patients had only one wound; therefore, the difference between the area of wound before and after treatment was estimated. The UCMSCs and ECFCs were injected into the wound along with topically applied hyaluronic acid (HA). Results. In this report, we compared the healing rate of multiple separate wounds in the same foot of the same patient: one treated with cell injection combined with topically applied HA-based hydrogel and was later covered by the hydrocolloid dressings, while the self-control wounds were only treated with conventional therapy and covered by the hydrocolloid dressings. The wound underwent cell injection showed accelerated healing in comparison to control wound within the first week after treatment. In other diabetic patients with only one refractory wound, the healing rate after cell transplantation was significantly faster than that before injection. Two large wounds healed without needing skin grafts after combination therapy of cell injection and HA. After four weeks of combination treatment, wound closure was reached in six patients, and the wounds of the other six patients were significantly reduced in size. Conclusions. Our study suggests that the combination of UCMSCs, ECFCs, and HA can safely synergize the accelerated healing of refractory diabetic foot ulcers.

scholarly journals Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
F. R. Henshaw ◽  
P. Boughton ◽  
L. Lo ◽  
S. V. McLennan ◽  
S. M. Twigg
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Ulcer Healing ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Wound Fluid ◽  
Diabetic Wounds

Aims/Hypothesis. Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken.Methods. Full thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound healing rate was observed on day 14 and wound sites were examined for breaking strength and granulation tissue. In the human study across 32 subjects, serial CTGF regulation was analyzed longitudinally in postdebridement diabetic wound fluid.Results. CTGF treated diabetic wounds had an accelerated closure rate compared with vehicle treated diabetic wounds. Healed skin withstood more strain before breaking in CTGF treated rat wounds. Granulation tissue from CTGF treatment in diabetic wounds showed collagen IV accumulation compared with nondiabetic animals. Woundα-smooth muscle actin was increased in CTGF treated diabetic wounds compared with untreated diabetic wounds, as was macrophage infiltration. Endogenous wound fluid CTGF protein rate of increase in human diabetic foot ulcers correlated positively with foot ulcer healing rate (r=0.406;P<0.001).Conclusions/Interpretation. These data collectively increasingly substantiate a functional role for CTGF in human diabetic foot ulcers.

scholarly journals Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

2021 ◽  
pp. 1-4
Author(s):  
Astasio Picado Álvaro ◽  
Keyword(s):  
Negative Pressure ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Negative Pressure Therapy ◽  
Novel Therapy ◽  
Pressure Therapy ◽  
Advanced Therapy ◽  
Global Increase

The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

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