A study of effect of cephalosporin drug loaded topical nanogel formulation on the bacterial load of diabetic foot ulcers load of diabetic foot ulcers

2018 ◽  
Vol 09 ◽  
Author(s):  
M S Umashankar ◽  
K S Lakshmi
Keyword(s):  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

2021 ◽  
pp. 1-4
Author(s):  
Astasio Picado Álvaro ◽  
Keyword(s):  
Negative Pressure ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Negative Pressure Therapy ◽  
Novel Therapy ◽  
Pressure Therapy ◽  
Advanced Therapy ◽  
Global Increase

The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

scholarly journals Bacterial Load Predicts Healing Rate in Neuropathic Diabetic Foot Ulcers

Diabetes Care ◽  
2007 ◽  
Vol 30 (2) ◽  
pp. 378-380 ◽  
Author(s):  
L. Xu ◽  
S. V. McLennan ◽  
L. Lo ◽  
A. Natfaji ◽  
T. Bolton ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Healing Rate ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

2021 ◽  
pp. 1-4
Author(s):  
Astasio Picado Álvaro ◽  
Keyword(s):  
Negative Pressure ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Negative Pressure Therapy ◽  
Novel Therapy ◽  
Pressure Therapy ◽  
Advanced Therapy ◽  
Global Increase

The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

scholarly journals Clinical and Antimicrobial Efficacy of a Silver Foam Dressing With Silicone Adhesive in Diabetic Foot Ulcers With Mild Infection

2019 ◽  
Vol 18 (3) ◽  
pp. 269-278 ◽  
Author(s):  
José Luis Lázaro-Martínez ◽  
Francisco Javier Álvaro-Afonso ◽  
David Sevillano-Fernández ◽  
Raúl Juan Molines-Barroso ◽  
Yolanda García-Álvarez ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Period ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Microbiological Analysis ◽  
Diabetic Foot Ulcers ◽  
Silicone Adhesive

The use of an antimicrobial dressing instead of a non-antimicrobial dressing may increase the number of diabetic foot ulcers healed over a medium-term follow-up period. The study aim was to evaluate the clinical and microbiological efficacy of a silver foam dressing in the management of diabetic foot ulcers. We conducted a single-center, prospective, open, noncontrolled study involving 21 outpatients with diabetic foot ulcers with mild infection. All patients received standard of care for their wounds and a silver foam dressing with silicone adhesive was applied twice per week for wound management during a 6-week treatment period. Soft tissue punch biopsies were taken every second week for qualitative and quantitative microbiological analysis. Wounds were assessed at patient admission, and wound bed tissue was evaluated for presence, quality, and consistency of granulation tissue. Clinical evaluation revealed improvements in wound conditions as a result of treatment with the silver dressing. Wollina wound scores improved significantly, from a mean score of 3.9 ± 1.6 points at inclusion to 6.1 ± 1.3 points at the end of the study (n = 19, P < .001). Treatment with the silver dressing resulted in significant decreases in the bioburden of classically considered diabetic foot ulcer pathogenic organisms such as Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, Enterobacteriaceae species, Pseudomonas aeruginosa, and other nonfermenting gram-negative bacilli. Findings revealed that the use of silver foam dressing significantly reduced the pathogenic bacterial load and markedly improved the clinical outcome in patients with diabetic foot ulcer with mild infection over a 6-week treatment period.

scholarly journals The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers

2020 ◽  
Vol 17 (6) ◽  
pp. 1986-1995
Author(s):  
Lawrence A. Lavery ◽  
Amanda L. Killeen ◽  
David Farrar ◽  
Yucel Akgul ◽  
Peter A. Crisologo ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Oxygen Treatment

The Use of Superoxidized Aqueous Solution versus Saline as a Replacement Solution in the Versajet Lavage System in Chronic Diabetic Foot Ulcers

2011 ◽  
Vol 101 (2) ◽  
pp. 124-126 ◽  
Author(s):  
Frank L. Bowling ◽  
Ryan T. Crews ◽  
Eleanna Salgami ◽  
David G. Armstrong ◽  
Andrew J.M. Boulton
Keyword(s):  
Aqueous Solution ◽  
Diabetic Foot ◽  
Chronic Wounds ◽  
Bacterial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Air Contamination ◽  
Jet Lavage ◽  
Significant Difference ◽  
Replacement Solution

Background: The removal of necrotic tissue from chronic wounds is required for wound healing to occur. Hydrodebridement (jet lavage) and superoxidized aqueous solution have been independently used for debriding wounds. We sought to investigate the use of superoxidized aqueous solution with a jet lavage system. Methods: Twenty patients with diabetic foot ulcers were randomly assigned in a 1:1 ratio to receive jet lavage debridement with either superoxidized aqueous solution or standard saline weekly. Results: There was no significant difference between the two treatments in the reduction of bacterial load or wound size in 4 weeks. No adverse reactions were reported for either treatment. Conclusions: The use of superoxidized aqueous solution for jet lavage debridement seemed to be as safe and effective as saline. Future investigations should concentrate on whether superoxidized aqueous solution may reduce the bacterial air contamination associated with hydrodebridement. (J Am Podiatr Med Assoc 101(2): 124–126, 2011)

Antimicrobial Photodynamic Therapy in Infected Diabetic Foot Ulcers: A Multicenter Preliminary Experience

2020 ◽  
Vol 110 (1) ◽  
Author(s):  
Matteo Monami ◽  
Alessia Scatena ◽  
Michael Schlecht ◽  
Ralf Lobmann ◽  
Letizia Landi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Healing Process ◽  
Red Light ◽  
Wound Management ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Foot Infections ◽  
Management Procedure

Background: The increasing resistance of bacteria to antibiotics and the frequency of comorbid conditions of patients make the treatment of diabetic foot infections problematic. In this context, photodynamic therapy could be a useful tool to treat infected wounds. The aim of this study was to evaluate the effect of repeated applications of a phthalocyanine derivative (RLP068) on the bacterial load and on the healing process. Methods: The present analysis was performed on patients with clinically infected ulcers who had been treated with RLP068. A sample for microbiological culture was collected at the first visit before and immediately after the application of RLP068 on the ulcer surface, and the area was illuminated for 8 minutes with a red light. The whole procedure was repeated three times per week at two centers (Florence and Arezzo, Italy) (sample A), and two times per week at the third center (Stuttgart, Germany) (sample B) for 2 weeks. Results: Sample A and sample B were composed of 55 and nine patients, respectively. In sample A, bacterial load decreased significantly after a single treatment, and the benefit persisted for 2 weeks. Similar effects of the first treatment were observed in sample B. In both samples, the ulcer area showed a significant reduction during follow-up, even in patients with ulcers infected with gram-negative germs or with exposed bone. Conclusions: RLP068 seems to be a promising topical wound management procedure for the treatment of infected diabetic foot ulcers.

Retrospective Matched Case-Control Study on the Use of CO2 Laser for the Treatment of Nonhealing Diabetic Foot Ulcers: The DULCIS-2 (Diabetic ULcer, CO2 Laser, and Infections) Study

2020 ◽  
pp. 153473462096029
Author(s):  
Matteo Monami ◽  
Benedetta Ragghianti ◽  
Antonio Silverii ◽  
Alessia Scatena ◽  
Letizia Landi ◽  
...  
Keyword(s):  
Co2 Laser ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Negative Impact ◽  
Bacterial Load ◽  
Case Control ◽  
Foot Ulcers ◽  
Surgical Approaches ◽  
Diabetic Foot Ulcers ◽  
Diabetic Ulcer

Purpose Infection, which is one of the possible complications of diabetic foot ulcers (DFUs), makes the treatment of ulcers challenging because of its negative impact on healing processes and the high prevalence of multiresistant germs. This study is aimed at verifying the effect of a surgical CO2 laser (which reduces the bacterial load and allows a more accurate debridement), as compared with the traditional lancets, on the healing rate of DFU. Methods The present case-control retrospective analysis was performed on patients with chronic (>6 months) DFU with Texas grade >1, treated with 80 W surgical CO2 laser (DEKA SmartXide2 C80, El.En. Group) and compared with a matched sample of patients with similar characteristics, who were treated with a traditional surgical approach. The debridement was performed trying to achieve the complete removal of nonviable tissues. The principal endpoint was the proportion of patients healed at 6 months. All analyses were carried out with SPSS 25.0. The study protocol was approved by the local ethical committee. Results This study included 118 patients (59 cases and 59 controls). At 6 months, the proportion of healing patients was 35% and 18% in cases and controls, respectively ( P = .034). The corresponding figure at 1 year was 62% and 38% ( P = .009), whereas no difference was observed at 1, 2, and 3 months. No serious adverse event was observed. Conclusions In this article, we show for the first time that CO2 laser treatment, in comparison with traditional surgical approaches, can be associated with an increased healing rate in patients with DFU.

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