Resting Heart Rate in Middle Age and Diabetes Development in Older Age

Background: Heart rate variability has been considered as an indicator of autonomic nerve function status. Few works have been done to assess the heart rate variability in normal healthy subjects in different countries. Objectives: To assess the cardiac autonomic nerve function status in healthy Bangladeshi population of different age groups by analyzing time domain measures of Heart Rate Variability. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from the period of July 2012 to June 2013. For this purpose, a total number of 180 healthy subjects were selected with the age ranging from 15-60 years of both sexes. All the study subjects were divided into 3 different groups according to age (Control 15-30 years; middle age 31-45 years; older age 46-60 years). Each group included 60 subjects of which 30 were male and 30 were female. The subjects were selected from different areas of Dhaka city by personal contacts. HRV parameters were recorded by a 4 active channels, RMS Polyrite-D-2 machine For statistical analysis, one way ANOVA, unpaired Students t-test and Pearsons correlation coefficient test were performed. as applicable. Results: Systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly (p<0.001) higher in older group in comparison to control & middle age group. Again RR interval and RMSSD (p<0.001), were significantly lower in older age group (p<0.05) compared to control & also to middle age group. But HR was found significantly higher (p<0.05)in both middle and older subjects than control and also in older (p<0.05) compared to middle age. Correlation analysis showed moderate negative correlation of mean R-R with age in middle age whereas significant negative correlation for RMSSD both in middle and older age subjects. Conclusion: In this study, markedly decreased cardiac parasympathetic function were found with aging process. DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22801 Bangladesh Soc Physiol. 2014, December; 9(2): 78-82

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Childhood Bradycardia Associates With Atrioventricular Conduction Defects in Older Age: A Longitudinal Birth Cohort Study

Journal of the American Heart Association ◽

10.1161/jaha.121.021877 ◽

2021 ◽

Vol 10 (19) ◽

Author(s):

Constantin‐Cristian Topriceanu ◽

James C. Moon ◽

Rebecca Hardy ◽

Alun D. Hughes ◽

Gabriella Captur

Keyword(s):

Heart Rate ◽

Birth Cohort ◽

Generalized Linear Models ◽

Linear Models ◽

Left Ventricular ◽

Older Age ◽

Atrioventricular Conduction ◽

Resting Heart Rate ◽

Fractional Polynomials ◽

Ventricular Conduction

Background This study explored the association between childhood bradycardia and later‐life cardiac phenotype using longitudinal data from the 1946 National Survey of Health and Development (NSHD) birth cohort. Methods and Results Resting heart rate was recorded at 6 and 7 years of age to provide the bradycardia exposure defined as a childhood resting heart rate <75 bpm. Three outcomes were studied: (1) echocardiographic data at 60 to 64 years of age, consisting of ejection fraction, left ventricular mass index, myocardial contraction fraction index, and E/e′; (2) electrocardiographic evidence of atrioventricular or ventricular conduction defects by 60 to 64 years of age; and (3) all‐cause and cardiovascular mortality. Generalized linear models or Cox regression models were used, and adjustment was made for relevant demographic and health‐related covariates, and for multiple testing. Mixed generalized linear models and fractional polynomials were used as sensitivity analyses. One in 3 older adults with atrioventricular conduction defects had been bradycardic in childhood, with defects being serious (Mobitz type II second‐degree atrioventricular block or higher) in 12%. In fully adjusted models, childhood bradycardia was associated with 2.91 higher odds of atrioventricular conduction defects (95% CI, 1.59–5.31; P =0.0005). Associations persisted in random coefficients mixed generalized linear models (odds ratio, 2.50; 95% CI, 1.01–4.31). Fractional polynomials confirmed a linear association between the log odds of atrioventricular conduction defects at 60 to 64 years of age and resting heart rate at 7 years of age. There was no association between bradycardia in childhood and mortality outcomes or with echocardiographic parameters and ventricular conduction defects in older age. Conclusions Longitudinal birth cohort data indicate that childhood bradycardia trebles the odds of having atrioventricular conduction defects in older age, 88% of which are benign. In addition, it does not influence mortality or heart size and function. Future research should concentrate on identifying children at risk.

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Heart rate recovery after maximal exercise is blunted in hypertensive seniors

Journal of Applied Physiology ◽

10.1152/japplphysiol.00395.2014 ◽

2014 ◽

Vol 117 (11) ◽

pp. 1302-1307 ◽

Cited By ~ 12

Author(s):

Stuart A. Best ◽

Tiffany B. Bivens ◽

M. Dean Palmer ◽

Kara N. Boyd ◽

M. Melyn Galbreath ◽

...

Keyword(s):

Heart Rate ◽

Autonomic Function ◽

Maximal Exercise ◽

Middle Age ◽

Treadmill Exercise ◽

Heart Rate Recovery ◽

Older Age ◽

Graded Exercise ◽

Stage 1 ◽

Normotensive Control

Abnormal heart rate recovery (HRR) after maximal exercise may indicate autonomic dysfunction and is a predictor for cardiovascular mortality. HRR is attenuated with aging and in middle-age hypertensive patients, but it is unknown whether HRR is attenuated in older-age adults with hypertension. This study compared HRR among 16 unmedicated stage 1 hypertensive (HTN) participants [nine men/seven women; 68 ± 5 (SD) yr; awake ambulatory blood pressure (BP) 149 ± 10/87 ± 7 mmHg] and 16 normotensive [control (CON)] participants (nine men/seven women; 67 ± 5 yr; 122 ± 4/72 ± 5 mmHg). HR, BP, oxygen uptake (V̇o2), cardiac output (Qc), and stroke volume (SV) were measured at rest, at two steady-state work rates, and graded exercise to peak during maximal treadmill exercise. During 6 min of seated recovery, the change in HR (ΔHR) was obtained every minute and BP every 2 min. In addition, HRR and R-R interval (RRI) recovery kinetics were analyzed using a monoexponential function, and the indexes (HRRI and RRII) were calculated. Maximum V̇o2, HR, Qc, and SV responses during exercise were not different between groups. ΔHR was significantly different ( P < 0.001) between the HTN group (26 ± 8) and the CON group (36 ± 12 beats/min) after 1 min of recovery but less convincing at 2 min ( P = 0.055). BP recovery was similar between groups. HRRI was significantly lower ( P = 0.016), and there was a trend of lower RRII ( P = 0.066) in the HTN group compared with the CON group. These results show that in older-age adults, HRR is attenuated further with the presence of hypertension, which may be attributable to an impairment of autonomic function.

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Regional Frontal Lobe Response Magnitudes During Affective Shifting Covary With Resting Heart Rate Variability in Healthy Volunteers

Journal of Psychophysiology ◽

10.1027/0269-8803/a000166 ◽

2016 ◽

Vol 30 (4) ◽

pp. 165-174 ◽

Cited By ~ 3

Author(s):

Ryan Smith ◽

John J.B. Allen ◽

Julian F. Thayer ◽

Richard D. Lane

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Healthy Subjects ◽

Emotional Reactivity ◽

Bold Signal ◽

Resting Heart Rate ◽

Functional Magnetic Resonance ◽

Absolute Value ◽

Cardiac Vagal Control ◽

Resting Heart Rate Variability

Abstract. We hypothesized that in healthy subjects differences in resting heart rate variability (rHRV) would be associated with differences in emotional reactivity within the medial visceromotor network (MVN). We also probed whether this MVN-rHRV relationship was diminished in depression. Eleven healthy adults and nine depressed subjects performed the emotional counting stroop task in alternating blocks of emotion and neutral words during functional magnetic resonance imaging (fMRI). The correlation between rHRV outside the scanner and BOLD signal reactivity (absolute value of change between adjacent blocks in the BOLD signal) was examined in specific MVN regions. Significant negative correlations were observed between rHRV and average BOLD shift magnitude (BSM) in several MVN regions in healthy subjects but not depressed subjects. This preliminary report provides novel evidence relating emotional reactivity in MVN regions to rHRV. It also provides preliminary suggestive evidence that depression may involve reduced interaction between the MVN and cardiac vagal control.

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