Inducement of antibody that mimics insulin action on insulin receptor by insulin autoantibody directed at determinant at asparagine site on human insulin B chain

Diabetes ◽

10.2337/diabetes.40.8.966 ◽

1991 ◽

Vol 40 (8) ◽

pp. 966-970 ◽

Author(s):

Y. Uchigata ◽

S. Takayama-Hasumi ◽

K. Kawanishi ◽

Y. Hirata

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Action ◽

Insulin Autoantibody

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Inducement of Antibody That Mimics Insulin Action on Insulin Receptor by Insulin Autoantibody Directed at Determinant at Asparagine Site on Human Insulin B Chain

Diabetes ◽

10.2337/diab.40.8.966 ◽

1991 ◽

Vol 40 (8) ◽

pp. 966-970 ◽

Author(s):

Y. Uchigata ◽

S. Takayama-Hasumi ◽

K. Kawanishi ◽

Y. Hirata

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Action ◽

Insulin Autoantibody

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Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42456-8 ◽

1992 ◽

Vol 267 (12) ◽

pp. 8383-8389 ◽

Author(s):

A Cama ◽

M.J. Quon ◽

M de la Luz Sierra ◽

S.I. Taylor

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Tyrosine Kinase ◽

Insulin Action ◽

Kinase Activity ◽

Beta Subunit ◽

Tyrosine Kinase Activity ◽

Receptor Endocytosis ◽

Human Insulin Receptor

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Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.79.23.7312 ◽

1982 ◽

Vol 79 (23) ◽

pp. 7312-7316 ◽

Author(s):

R. A. Roth ◽

D. J. Cassell ◽

K. Y. Wong ◽

B. A. Maddux ◽

I. D. Goldfine

Keyword(s):

Monoclonal Antibodies ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Action ◽

Insulin Binding ◽

Human Insulin Receptor ◽

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Different Ligand Affinities of the Two Human Insulin Receptor Splice Variants Are Reflected in Parallel Changes in Sensitivity for Insulin Action

Molecular Endocrinology ◽

10.1210/mend-5-5-734 ◽

1991 ◽

Vol 5 (5) ◽

pp. 734-739 ◽

Author(s):

Donald A. McClain

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Action ◽

Splice Variants ◽

Human Insulin Receptor

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Vanadate augments insulin-stimulated insulin receptor kinase activity and prolongs insulin action in rat adipocytes. Evidence for transduction of amplitude of signaling into duration of response

Diabetes ◽

10.2337/diabetes.43.3.375 ◽

1994 ◽

Vol 43 (3) ◽

pp. 375-383 ◽

Author(s):

I. G. Fantus ◽

F. Ahmad ◽

G. Deragon

Keyword(s):

Insulin Receptor ◽

Insulin Action ◽

Kinase Activity ◽

Receptor Kinase ◽

Rat Adipocytes ◽

Duration Of Response ◽

Insulin Receptor Kinase ◽

Insulin Receptor Kinase Activity

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Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction

Diabetes ◽

10.2337/diabetes.39.1.123 ◽

1990 ◽

Vol 39 (1) ◽

pp. 123-128 ◽

Author(s):

S. Seino ◽

M. Seino ◽

G. I. Bell

Keyword(s):

Polymerase Chain Reaction ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Gene ◽

Partial Sequence ◽

Chain Reaction ◽

Insulin Receptor Gene ◽

Human Insulin Receptor ◽

Polymerase Chain

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Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)81632-0 ◽

1989 ◽

Vol 264 (5) ◽

pp. 2438-2444 ◽

Author(s):

D M Hawley ◽

B A Maddux ◽

R G Patel ◽

K Y Wong ◽

P W Mamula ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Tyrosine Kinase ◽

Insulin Receptor ◽

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Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30636-1 ◽

1990 ◽

Vol 265 (31) ◽

pp. 19143-19150

Author(s):

T Kadowaki ◽

H Kadowaki ◽

D Accili ◽

S.I. Taylor

Keyword(s):

Cell Surface ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Alpha Subunit ◽

Human Insulin Receptor

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Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38291-2 ◽

1990 ◽

Vol 265 (22) ◽

pp. 13248-13253 ◽

Author(s):

E M Schaefer ◽

K Siddle ◽

L Ellis

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Deletion Analysis ◽

Alpha Subunit ◽

Human Insulin Receptor

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Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50389-1 ◽

1992 ◽

Vol 267 (13) ◽

pp. 9065-9070

Author(s):

Y Takata ◽

N.J. Webster ◽

J.M. Olefsky

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Intracellular Signaling ◽

Human Insulin Receptor ◽

Carboxyl Terminal ◽

Tyrosine Autophosphorylation

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