Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid

ABSTRACT To elucidate the hypolipacidaemic effect of insulin in ducks, its action on the uptake of free fatty acids (FFA) by duck hepatocytes was determined. At low doses (10 mu./l) insulin stimulated FFA uptake. This effect was not observed with higher doses of insulin (20, 30 and 50 mu./l). Growth hormone at physiological concentrations and corticosterone (14·4 nmol/l) decreased basal activity, probably by reducing glucose metabolism and consequently α-glycerophosphate (α-GP) supply. Insulin was able to reverse the inhibition induced by GH and corticosterone on both FFA uptake and α-GP production. These results therefore suggest that the hypolipacidaemic effect of insulin may be partly mediated by its action on hepatic FFA uptake. J. Endocr. (1984) 102, 381–386

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Effects of long-term pressure overload on regional myocardial glucose and free fatty acid uptake in rats. A quantitative autoradiographic study.

Circulation ◽

10.1161/01.cir.81.4.1353 ◽

1990 ◽

Vol 81 (4) ◽

pp. 1353-1361 ◽

Cited By ~ 97

Author(s):

Y Kagaya ◽

Y Kanno ◽

D Takeyama ◽

N Ishide ◽

Y Maruyama ◽

...

Keyword(s):

Fatty Acid ◽

Free Fatty Acid ◽

Pressure Overload ◽

Fatty Acid Uptake ◽

Autoradiographic Study ◽

Acid Uptake

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Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00187.2014 ◽

2014 ◽

Vol 307 (4) ◽

pp. E374-E383 ◽

Cited By ~ 42

Author(s):

Myriam Aouadi ◽

Pranitha Vangala ◽

Joseph C. Yawe ◽

Michaela Tencerova ◽

Sarah M. Nicoloro ◽

...

Keyword(s):

Fatty Acids ◽

Adipose Tissue ◽

Fatty Acid ◽

Glucose Tolerance ◽

Glucose Intolerance ◽

Fatty Acid Uptake ◽

Foam Cell Formation ◽

Acid Uptake ◽

Obese Mice ◽

Adipose Tissue Macrophages

Proinflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for excess lipid that adipocytes are unable to store. To test this hypothesis, we selectively targeted visceral ATMs in obese mice with siRNA against lipoprotein lipase (LPL), leaving macrophages within other organs unaffected. Selective silencing of ATM LPL decreased foam cell formation in visceral adipose tissue of obese mice, consistent with a reduced supply of fatty acids from VLDL hydrolysis. Unexpectedly, silencing LPL also decreased the expression of genes involved in fatty acid uptake (CD36) and esterification in ATMs. This deficit in fatty acid uptake capacity was associated with increased circulating serum free fatty acids. Importantly, ATM LPL silencing also caused a marked increase in circulating fatty acid-binding protein-4, an adipocyte-derived lipid chaperone previously reported to induce liver insulin resistance and glucose intolerance. Consistent with this concept, obese mice with LPL-depleted ATMs exhibited higher hepatic glucose production from pyruvate and glucose intolerance. Silencing CD36 in ATMs also promoted glucose intolerance. Taken together, the data indicate that LPL secreted by ATMs enhances their ability to sequester excess lipid in obese mice, promoting systemic glucose tolerance.

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12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Cell Metabolism ◽

10.1016/j.cmet.2018.03.020 ◽

2018 ◽

Vol 27 (5) ◽

pp. 1111-1120.e3 ◽

Cited By ~ 57

Author(s):

Kristin I. Stanford ◽

Matthew D. Lynes ◽

Hirokazu Takahashi ◽

Lisa A. Baer ◽

Peter J. Arts ◽

...

Keyword(s):

Skeletal Muscle ◽

Fatty Acid ◽

Fatty Acid Uptake ◽

Acid Uptake ◽

Exercise Induced

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Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells

Food & Function ◽

10.1039/c4fo00435c ◽

2015 ◽

Vol 6 (1) ◽

pp. 172-184 ◽

Cited By ~ 27

Author(s):

Barbara Rohm ◽

Annett Riedel ◽

Jakob P. Ley ◽

Sabine Widder ◽

Gerhard E. Krammer ◽

...

Keyword(s):

Fatty Acid ◽

Free Fatty Acid ◽

Coenzyme A ◽

Fatty Acid Uptake ◽

Synthetase Activity ◽

Acid Uptake ◽

Structural Element ◽

Acetyl Coenzyme A ◽

Acetyl Coenzyme

The effects of capsaicin, nonivamide,trans-pellitorine and vanillin as the basic structural element of all vanilloids on the mechanisms of intestinal fatty acid uptake in differentiated intestinal Caco-2 cells were studied.

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