scholarly journals Low Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients: An Indicator of More Advanced Glomerular Lesions

Diabetes ◽  
2003 ◽  
Vol 52 (4) ◽  
pp. 1036-1040 ◽  
Author(s):  
M. L. Caramori ◽  
P. Fioretto ◽  
M. Mauer
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Glomerular Lesions ◽  
Type 1 Diabetic Patients

scholarly journals Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy

2011 ◽  
Vol 79 (10) ◽  
pp. 1113-1118 ◽  
Author(s):  
Stine E. Nielsen ◽  
Steen Andersen ◽  
Dietmar Zdunek ◽  
Georg Hess ◽  
Hans-Henrik Parving ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Overt Nephropathy ◽  
Tubular Markers ◽  
Type 1 Diabetic Patients

scholarly journals Evaluation of creatinine-based and cystatin C-based equations for estimation of glomerular filtration rate in type 1 diabetic patients

2016 ◽  
Vol 60 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Caroline Pereira Domingueti ◽  
Rodrigo Bastos Fóscolo ◽  
Ana Cristina Simões e Silva ◽  
Luci Maria S. Dusse ◽  
Janice Sepúlveda Reis ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Hyperadiponectinemia Is Independent of Kidney Function, Diabetes Duration, and Control in Type 1 Diabetic Patients without Microangiopathy

2011 ◽  
Vol 96 (3) ◽  
pp. E485-E487 ◽  
Author(s):  
Charbel Abi Khalil ◽  
Kamel Mohammedi ◽  
Roberte Aubert ◽  
Elizabeth Abou Jaoude ◽  
Florence Travert ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Kidney Function ◽  
Filtration Rate ◽  
Glycosylated Hemoglobin ◽  
Diabetes Duration ◽  
Diabetic Patients ◽  
Insulin Levels

Introduction: High total adiponectin (ADPN) levels were reported in type 1 diabetes (T1D) and related to long diabetes duration and nephropathy. We studied whether ADPN and its specific isoforms were elevated in T1D without microangiopathy and whether they were related to kidney function. Materials and Methods: Total, high, medium, and low molecular weight ADPN and insulin levels were measured in 47 consecutive normoalbuminuric, normotensive T1D patients without retinopathy and in 47 age-, sex-, and body mass index-matched controls. Glomerular filtration rate was estimated by 51Cr-EDTA plasma clearance. Results: Total and high molecular weight ADPN ratio were higher in T1D patients than in controls. ADPN levels were not related to anthropometric measures, whereas they were in controls. In T1D, ADPN levels were not related to glycosylated hemoglobin, diabetes duration, or glomerular filtration rate. Peripheral insulin levels were higher in T1D patients than in controls, but they were not related to ADPN levels. In controls, insulin levels were positively related to total ADPN. Conclusion: In T1D without microangiopathy, high ADPN levels could not be related to anthropometric diabetes parameters, kidney function, or high insulin levels. The nature of this elevation remains unknown.

scholarly journals Normoalbuminuric Diabetic Kidney Disease- Need for Renal Biopsy? An Autopsy Study on Western Indian Population

2020 ◽  
Vol 7 (10) ◽  
pp. A483-490
Author(s):  
Sonal Paul ◽  
Nitin M Gadgil ◽  
Anitha Padmanabhan
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Interstitial Fibrosis ◽  
Clinical Manifestations ◽  
Vascular Lesions ◽  
Diabetic Patients ◽  
Autopsy Study ◽  
Tubular Atrophy ◽  
Glomerular Lesions

Introduction: Persistent albuminuria and glomerular filtration rate are considered as the gold standard for the diagnosis of Diabetic Nephropathy (DN). Methods: In this autopsy study, we evaluated data from a cohort of 67 patients with Type 2 Diabetes Mellitus. We determined the histological prevalence of DN irrespective of the clinical manifestations of renal disease. Patients were stratified by proteinuria and estimated glomerular filtration rate(eGFR). The glomerular, interstitial and vascular lesions were scored as per the established histopathologic classification for DN. Results: 55 of the 67 patients had clinical as well as histological lesions consistent with DN. 12 patients had histological lesions of DN at autopsy but no clinical evidence of proteinuria, including microalbuminuria in their lifetime.4 of these patients had maintained eGFR. There was no difference in the glomerular lesions in patients with normoalbuminuria regardless of the eGFR. However,50% of the patients with low eGFR showed presence of interstitial fibrosis and tubular atrophy while no interstitial lesions were noted in patients with normoalbuminuria and maintained eGFR. Significant amount of arteriosclerosis was noted in the normoalbuminuric low eGFR patients. Haematuria was significantly associated with proteinuric low GFR patients. Conclusion: Histological evidence of DN may be seen even in the absence of clinical manifestations, suggesting that, in diabetic kidneys some amount of glomerular and tubulointerstitial damage has already occurred before the onset of proteinuria. Hence, there is a need for routine kidney biopsies in diabetic patients with normoalbuminuria. This will help in the timely diagnosis and appropriate management in the early stages of DN.

scholarly journals Impaired autoregulation of glomerular filtration rate in Type 1 (insulin-dependent) diabetic patients with nephropathy

Diabetologia ◽  
1984 ◽  
Vol 27 (6) ◽  
pp. 547-552 ◽  
Author(s):  
H. -H. Parving ◽  
H. Kastrup ◽  
U. M. Smidt ◽  
A. R. Andersen ◽  
B. Feldt-Rasmussen ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

1695-P: Genetic Determinants of Estimated Glomerular Filtration Rate (eGFR) in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1695-P
Author(s):  
STUART MCGURNAGHAN ◽  
ATHINA SPILIOPOULOU ◽  
HELEN M. COLHOUN ◽  
PAUL M. MCKEIGUE
Keyword(s):  
Type 1 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Genetic Determinants
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