scholarly journals Reduction of protein intake decreases glomerular filtration rate in young Type 1 (insulin-dependent) diabetic patients mainly in hyperfiltering patients

Diabetologia ◽  
1988 ◽  
Vol 31 (12) ◽  
Author(s):  
S. Rudberg ◽  
G. Dahlquist ◽  
A. Aperia ◽  
B. Persson
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Protein Intake ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Impaired autoregulation of glomerular filtration rate in Type 1 (insulin-dependent) diabetic patients with nephropathy

Diabetologia ◽  
1984 ◽  
Vol 27 (6) ◽  
pp. 547-552 ◽  
Author(s):  
H. -H. Parving ◽  
H. Kastrup ◽  
U. M. Smidt ◽  
A. R. Andersen ◽  
B. Feldt-Rasmussen ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Exercise-induced changes in renal function and their relation to plasma noradrenaline in insulin-dependent diabetic children and adolescents

1987 ◽  
Vol 72 (5) ◽  
pp. 611-620 ◽  
Author(s):  
B.-L. Johansson ◽  
U. Berg ◽  
A.-B. Bohlin ◽  
A.-K. Lefvert ◽  
U. Freyschuss
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Plasma Noradrenaline ◽  
Diabetic Patients ◽  
Diabetic Children ◽  
Insulin Dependent ◽  
Exercise Induced ◽  
Insulin Dependent Diabetic ◽  
Induced Changes

1. Exercise-induced changes in renal haemodynamics, water homoeostasis, urinary albumin excretion and their possible relation to plasma noradrenaline were studied in seven insulin-dependent diabetic children and adolescents without signs of autonomic or somatic neuropathy. Six age-matched clinically healthy patients in remission from the minimal change nephrotic syndrome served as controls. 2. The diabetic patients had a higher glomerular filtration rate and effective renal plasma flow and a lower venous plasma noradrenaline level in the basal state. They also had a higher systolic blood pressure compared with the controls. During exercise the diabetic patients showed a less marked reduction in glomerular filtration rate and urinary flow and a greater increase in filtration fraction. Their heart rate increase during exercise was lower. An inverse correlation between the percentage changes in noradrenaline and glomerular filtration rate during exercise was noted solely in the diabetic patients. They also showed a less marked increase in the ratio between potassium and sodium clearances during and 20 min after exercise. Albumin excretion did not differ between the two groups. 3. We suggest that the sympatho-adrenergic effects of exercise on heart rate, renal haemodynamics and water homoeostasis are blunted in our diabetic patients. Hence, signs of impaired sympathetic activity might be disclosed in young diabetic patients with a disease of fairly short duration.

Feedback-mediated reduction in glomerular filtration during acetazolamide infusion in insulin-dependent diabetic patients

1991 ◽  
Vol 81 (s25) ◽  
pp. 457-464 ◽  
Author(s):  
T. Hannedouche ◽  
M. Lazaro ◽  
A. G. Delgado ◽  
C. Boitard ◽  
B. Lacour ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Angiotensin Ii ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Feedback System ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Before And After ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

1. A sustained high glomerular filtration rate in diabetes mellitus is associated with increased proximal reabsorption, suggesting alterations in the tubulo-glomerular feedback system. To test this hypothesis, renal function was studied in eight control subjects and 14 recent-onset euglycaemic insulin-dependent diabetic patients before and after infusion of the carbonic anhydrase inhibitor, acetazolamide (5 mg/kg body weight). 2. Acetazolamide induced a dramatic fall in glomerular filtration rate in both diabetic patients and control subjects (from 138 ± 5 to 114 ± 4 and from 127 ± 3 to 113 ± 2 ml min−1 1.73 m−2, respectively, P < 0.0001). This fall in glomerular filtration rate was strongly correlated with the acetazolamide-induced decrease in absolute proximal reabsorption calculated by using lithium clearance. 3. To further assess the potential role of angiotensin II in the acetazolamide-induced tubulo-glomerular feedback response, 11 additional diabetic patients were investigated before and after the administration of acetazolamide plus the angiotensin-converting enzyme inhibitor, enalaprilat (1.25 mg intravenously). Despite the effective blockade of angiotensin II formation and a slight decrease in renal vascular resistance, the glomerular filtration rate fell significantly and by a similar magnitude as seen with acetazolamide alone. 4. These results indirectly suggest that there is an altered basal tubulo-glomerular feedback system in diabetic patients but a normal response to the increase in distal delivery. No convincing role for an angiotensin II-mediated effect on the afferent limb of the tubulo-glomerular feedback response could be demonstrated.

scholarly journals Size- and charge selectivity of glomerular filtration in Type 1 (insulin-dependent) diabetic patients with and without albuminuria

Diabetologia ◽  
1993 ◽  
Vol 36 (3) ◽  
pp. 244-251 ◽  
Author(s):  
T. Deckert ◽  
A. Kofoed-Enevoldsen ◽  
P. Vidal ◽  
K. N�rgaard ◽  
H. B. Andreasen ◽  
...  
Keyword(s):  
Glomerular Filtration ◽  
Diabetic Patients ◽  
Charge Selectivity ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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