Screening and Treatment Outcomes in Adults and Children with Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study

Objective: To describe Celiac Disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in type 1 diabetes patients asymptomatic for CD. Research Design and Methods: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring (CGM) over 12 months. Results: Adults had higher CD-seropositivity rates than children (6.8%, 95%CI 4.9% to 8.2%, N=1298 vs. 4.7%; 95%CI 3.4% to 5.9%, N=1089, p=0.035) with lower rates of prior CD-screening (6.9% vs 44.2%, p<0.0001). 51 participants were randomized to a GFD (N=27) or GCD (N=24). No HbA1c differences were seen between groups (+0.14%, 1.5mmol/mol; 95%CI: -0.79 to 1.08; p=0.76) although greater post-prandial glucose increases (4-hr +1.5mmol/L; 95%CI: 0.4 to 2.7; p=0.014) emerged with a GFD. Conclusions: CD is frequently observed in asymptomatic patients with type 1 diabetes and clinical vigilance is warranted with initiation of a GFD.

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Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study

Diabetes Care ◽

10.2337/dc19-1944 ◽

2020 ◽

Vol 43 (7) ◽

pp. 1553-1556 ◽

Cited By ~ 1

Author(s):

Farid H. Mahmud ◽

Antoine B.M. Clarke ◽

Kariym C. Joachim ◽

Esther Assor ◽

Charlotte McDonald ◽

...

Keyword(s):

Type 1 Diabetes ◽

Celiac Disease ◽

Treatment Outcomes ◽

Adults And Children ◽

Diet Study

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Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

10.2337/figshare.17136692.v2 ◽

2022 ◽

Author(s):

Anagha Champakanath ◽

Halis Kaan Akturk ◽

G. Todd Alonso ◽

Janet K Snell-Bergeon ◽

Viral N Shah

Keyword(s):

Type 1 Diabetes ◽

Glucose Monitoring ◽

First Year ◽

Diabetes Diagnosis ◽

One Year ◽

Glycemic Outcomes ◽

Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c.

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Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

10.2337/figshare.17136692.v1 ◽

2022 ◽

Author(s):

Anagha Champakanath ◽

Halis Kaan Akturk ◽

G. Todd Alonso ◽

Janet K Snell-Bergeon ◽

Viral N Shah

Keyword(s):

Type 1 Diabetes ◽

Glucose Monitoring ◽

First Year ◽

Diabetes Diagnosis ◽

One Year ◽

Glycemic Outcomes ◽

Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c.

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Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

10.2337/figshare.17136692 ◽

2022 ◽

Author(s):

Anagha Champakanath ◽

Halis Kaan Akturk ◽

G. Todd Alonso ◽

Janet K Snell-Bergeon ◽

Viral N Shah

Keyword(s):

Type 1 Diabetes ◽

Glucose Monitoring ◽

First Year ◽

Diabetes Diagnosis ◽

One Year ◽

Glycemic Outcomes ◽

Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c.

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Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

Diabetes Care ◽

10.2337/dc21-2004 ◽

2022 ◽

Author(s):

Anagha Champakanath ◽

Halis Kaan Akturk ◽

G. Todd Alonso ◽

Janet K. Snell-Bergeon ◽

Viral N. Shah

Keyword(s):

Type 1 Diabetes ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

First Year ◽

Diabetes Diagnosis ◽

Glycemic Outcomes ◽

Design And Methods

OBJECTIVE To evaluate long-term glycemic outcomes of continuous glucose monitoring (CGM) initiation within the first year of type 1 diabetes diagnosis. RESEARCH DESIGN AND METHODS Patients with type 1 diabetes (N = 396) were divided into three groups: 1) CGM (CGM use within 1 year of diabetes diagnosis and continued through the study); 2) no-CGM (no CGM use throughout the study); and 3) new-CGM (CGM use after 3 years since diabetes diagnosis). Patients were followed up to 7 years. RESULTS A1c was significantly lower in the CGM compared with the no-CGM group throughout 7 years of follow-up (least squares mean A1c values: 6 months, 7.3% vs. 8.1%; 1 year, 7.4% vs. 8.6%; 2 years, 7.7% vs. 9.1%; 3 years, 7.6% vs. 9.3%; 4 years, 7.4% vs. 9.6%; 5 years, 7.6% vs. 9.7%; 6 years, 7.5% vs. 10.0%; and 7 years, 7.6% vs. 9.8%; for all, P < 0.001) adjusting for age at diagnosis, sex, and insulin delivery method. CONCLUSION CGM initiation within first year of type 1 diabetes diagnosis results in long-term improvement in A1c.

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