scholarly journals Accuracy of botulinum toxin type A injection into the gastrocnemius muscle of adults with spastic equinus: Manual needle placement and electrical stimulation guidance compared using ultrasonography

2012 ◽  
Vol 44 (5) ◽  
pp. 450-452 ◽  
Author(s):  
A Picelli ◽  
P Bonetti ◽  
C Fontana ◽  
M Barausse ◽  
F Dambruoso ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Botulinum Toxin ◽  
Gastrocnemius Muscle ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Needle Placement

scholarly journals Electrical Stimulation of Injected Muscles to Boost Botulinum Toxin Effect on Spasticity: Rationale, Systematic Review and State of the Art

Toxins ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 303
Author(s):  
Alessandro Picelli ◽  
Mirko Filippetti ◽  
Giorgio Sandrini ◽  
Cristina Tassorelli ◽  
Roberto De Icco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electrical Stimulation ◽  
Botulinum Toxin ◽  
Current Literature ◽  
Electric Stimulation ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Botulinum Toxins ◽  
Stimulation Of

Botulinum toxin type A (BoNT-A) represents a first-line treatment for spasticity, a common disabling consequence of many neurological diseases. Electrical stimulation of motor nerve endings has been reported to boost the effect of BoNT-A. To date, a wide range of stimulation protocols has been proposed in the literature. We conducted a systematic review of current literature on the protocols of electrical stimulation to boost the effect of BoNT-A injection in patients with spasticity. A systematic search using the MeSH terms “electric stimulation”, “muscle spasticity” and “botulinum toxins” and strings “electric stimulation [mh] OR electrical stimulation AND muscle spasticity [mh] OR spasticity AND botulinum toxins [mh] OR botulinum toxin type A” was conducted on PubMed, Scopus, PEDro and Cochrane library electronic databases. Full-text articles written in English and published from database inception to March 2021 were included. Data on patient characteristics, electrical stimulation protocols and outcome measures were collected. This systematic review provides a complete overview of current literature on the role of electrical stimulation to boost the effect of BoNT-A injection for spasticity, together with a critical discussion on its rationale based on the neurobiology of BoNT-A uptake.

Long-term efficacy and safety of a new botulinum toxin type A preparation in mouse gastrocnemius muscle

Toxicon ◽  
2020 ◽  
Vol 187 ◽  
pp. 163-170
Author(s):  
Jungtae Na ◽  
Esther Lee ◽  
Yu-jin Kim ◽  
Mi Ji Choi ◽  
Su-Young Kim ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Gastrocnemius Muscle ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Efficacy And Safety ◽  
Term Efficacy

scholarly journals Exercise training improves the adipocyte accumulation and muscle fibrosis of the muscle by TGF-β1 and α-SMA reduction after botulinum toxin type A administration in mice

2020 ◽  
Author(s):  
Esther Lee ◽  
Song I Im ◽  
Yu-jin Kim ◽  
Su Young Kim ◽  
Jungtae Na ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Gastrocnemius Muscle ◽  
Treadmill Exercise ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Histological Evaluation ◽  
Muscle Fibrosis ◽  
Volume Weight ◽  
Tgf Β1

Abstract Background: We aimed to investigate the effect of treadmill exercise on functional recovery of the mouse gastrocnemius muscle and nerve after botulinum toxin type A (BoNT-A) administration. Methods: After injecting 0.5 units of BoNT-A into the gastrocnemius muscle of ICR mice, treadmill exercise was carried out for a six-week period, after which the muscle volume, weight, and sciatic functional index (SFI) were obtained and nerve conduction study (NCS) and histological evaluation were performed. Results: There was no change in the gastrocnemius weight and volume, but NCS and SFI increased after exercise. Exercise prevented induced adipocyte accumulation and muscle fibrosis. Moreover, TGF-β1 and α-SMA expression decreased and CD34, BDNF, and SNAP-25 expression increased when treadmill exercise was performed after BoNT-A injection. Conclusions: The exercise was effective in the recovery of nerve function and would help in the recovery of muscle function by preventing accumulation of fat cells and muscle fibrosis after BoNT-A administration.

scholarly journals Exercise training improves adipocyte accumulation and muscle fibrosis by TGF-β1 and α-SMA reduction after botulinum toxin type A administration in mice

2020 ◽  
Author(s):  
Jungtae Na ◽  
Esther Lee ◽  
Song I Im ◽  
Yu-jin Kim ◽  
Su Young Kim ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Gastrocnemius Muscle ◽  
Transforming Growth Factor ◽  
Treadmill Exercise ◽  
Smooth Muscle Actin ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Histological Evaluation ◽  
Muscle Fibrosis

Abstract Background: We aimed to investigate the effect of treadmill exercise on functional recovery of the murine gastrocnemius muscle and nerve after botulinum toxin type A (BoNT-A) administration. Methods: After the injection of 0.5 units of BoNT-A into the gastrocnemius muscle of ICR mice, treadmill exercise was conducted for a 6-week period, after which the muscle volume, weight, and sciatic functional index (SFI) was determined and a nerve conduction study (NCS) and histological evaluation were performed. Results: After exercise, there was no change in the gastrocnemius weight and volume, but NCS and SFI increased. Exercise prevented induced adipocyte accumulation and muscle fibrosis. Moreover, transforming growth factor-β1 and α-smooth muscle actin expressions decreased and CD34, brain-derived neurotrophic factor, and synaptosomal nerve-associated protein 25 expressions increased when treadmill exercise was performed after BoNT-A administration. Conclusions: Exercise can effectively recover the nerve function and would aid in muscle function recovery by preventing fat cell accumulation and muscle fibrosis after BoNT-A administration.

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