Mindfulness-based cognitive therapy for severely fatigued multiple sclerosis patients: A waiting list controlled study

Thirty-five outpatients (25 women, 10 men) with a DSM-III-R principal diagnosis of OCD accepted exposure treatment at a psychiatric outpatient clinic. They were randomly assigned to one of two individual treatments for a 6-week exposure therapy treatment based on a treatment manual or to a 6-week waiting list condition. The 12 patients assigned to the waiting list were subsequently randomly assigned to one of the active treatments. Both treatment groups received in vivo or imaginal exposure in each of the 10 twice-weekly treatment sessions held after two assessment sessions. One group (n=16) received cognitive therapy interventions for comorbidity problems or to alter beliefs underlying patients' OCD. The other group (n=19) received relaxation training as an attention placebo control. Both groups received relapse prevention follow-up contacts. Twenty-seven patients completed intensive treatment. Both treatments overall showed satisfactory levels of clinical improvement and large effect sizes. ANCOVAS for treatment completers showed non-significantly lower levels of OCD symptoms, depression and state anxiety in the treatment condition that did not include cognitive interventions. The patients receiving additional cognitive therapy showed significantly lesser dropout than those in the other treatment condition, but there were no significant differences in the intention-to-treat analyses.

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Physical fitness assessment in multiple sclerosis patients: A controlled study

Research in Developmental Disabilities ◽

10.1016/j.ridd.2014.06.013 ◽

2014 ◽

Vol 35 (10) ◽

pp. 2527-2533 ◽

Cited By ~ 10

Author(s):

E. Guerra ◽

A. di Cagno ◽

P. Mancini ◽

F. Sperandii ◽

F. Quaranta ◽

...

Keyword(s):

Multiple Sclerosis ◽

Physical Fitness ◽

Controlled Study ◽

Fitness Assessment ◽

Multiple Sclerosis Patients

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Percutaneous tibial nerve stimulation is effective in the treatment of neurogenic overactive bladder in multiple sclerosis patients: A controlled study

European Urology Supplements ◽

10.1016/s1569-9056(19)31450-2 ◽

2019 ◽

Vol 18 (1) ◽

pp. e2003-e2004

Author(s):

P. Pacini ◽

V. Iacovelli ◽

F. Petta ◽

G. D’Ippolito ◽

R. Ragaglini ◽

...

Keyword(s):

Multiple Sclerosis ◽

Overactive Bladder ◽

Nerve Stimulation ◽

Tibial Nerve ◽

Controlled Study ◽

Percutaneous Tibial Nerve Stimulation ◽

Tibial Nerve Stimulation ◽

Multiple Sclerosis Patients

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Randomised multicentre trial on safety and efficacy of rivastigmine in cognitively impaired multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458512463481 ◽

2012 ◽

Vol 19 (5) ◽

pp. 631-638 ◽

Cited By ~ 18

Author(s):

M Mäurer ◽

S Ortler ◽

M Baier ◽

M Meergans ◽

P Scherer ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Deficits ◽

Memory Function ◽

Recall Score ◽

Analysis Of Covariance ◽

Controlled Study ◽

Cognitively Impaired ◽

Total Recall ◽

Double Blind ◽

Multiple Sclerosis Patients

Background: Cognitive decline has been recognised as a frequent symptom in multiple sclerosis (MS). Cholinesterase inhibitors (ChEIs) are employed for the treatment of Alzheimer’s disease, but there is some evidence that ChEIs might also be effective in MS patients with cognitive deficits, particularly deficits of memory function. Objective: The aim of this study was to evaluate efficacy on memory function and safety of the ChEI rivastigmine in MS patients with cognitive deficits as measured by the change from baseline of the total recall score of the selective reminding test (SRT) after 16 weeks of treatment. Methods: Efficacy and safety of rivastigmine were analysed in a 16-week, multicentre, double-blind, randomised, placebo-controlled study, followed by an optional one-year open-label treatment phase. Effects of rivastigmine and placebo were compared by an analysis of covariance. Results: In total, 86 patients were enrolled. Patients who received rivastigmine ( n = 43) showed a non-significant increase in total recall score (sum of all words immediately recalled over all six trials) over placebo ( n = 38) after 16 weeks of treatment ( p = 0.2576). Other outcome measures provided no evidence supporting benefits of rivastigmine. Treatment with rivastigmine was well tolerated. Conclusions: With the results of this study, the need for an effective therapy in cognitively impaired MS patients is still required. Thus, intensive and continued clinical research is required to explore therapeutic options for cognitive deficits in MS patients.

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Balance Rehabilitation Unit (BRU TM) posturography in relapsing-remitting multiple sclerosis

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2011000400015 ◽

2011 ◽

Vol 69 (3) ◽

pp. 485-490 ◽

Cited By ~ 7

Author(s):

Natália Kessler ◽

Maurício Malavasi Ganança ◽

Cristina Freitas Ganança ◽

Fernando Freitas Ganança ◽

Sabrina Chiogna Lopes ◽

...

Keyword(s):

Multiple Sclerosis ◽

Balance Control ◽

Controlled Study ◽

Rehabilitation Unit ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Multiple Sclerosis Patients ◽

Relapsing Remitting Multiple Sclerosis ◽

Balance Rehabilitation ◽

Ellipse Area

OBJECTIVE: To evaluate balance control with Balance Rehabilitation Unit (BRU TM) posturography in patients with multiple sclerosis (MS). METHOD: A cross controlled study was performed including 39 relapsing-remitting multiple sclerosis patients with scores less than or equal to 4 in the Expanded Disability Status Scale (EDSS), and a homogeneous control group consisting of 65 healthy individuals, matched by the age and gender. The experimental group was distributed according to the EDSS scale scores in 0-2.5 and 3-4. To assess the vestibular system function, the patients underwent a neurotological evaluation, including posturography of the Balance Rehabilitation Unit (BRU TM). RESULTS: Statistically significant differences were observed when comparing the values of the sway velocity and the ellipse area of the MS 0-2.5 group with the control and the MS 3-4 group with the control. A statistically significant difference was verified between the MS 0-2.5 and the MS 3-4 groups in the condition 3 ellipse area values. CONCLUSION: The evaluation of the balance control with posturography of Balance Rehabilitation Unit (BRU TM) enables the identification of abnormalities of the sway velocity and confidential ellipse in patients with relapsing-remitting multiple sclerosis.

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Applying Mindfulness Therapy in a Group of Psychotic Individuals: A Controlled Study

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465811000464 ◽

2011 ◽

Vol 40 (1) ◽

pp. 105-109 ◽

Cited By ~ 48

Author(s):

Álvaro I. Langer ◽

Adolfo J. Cangas ◽

Estela Salcedo ◽

Belén Fuentes

Keyword(s):

Cognitive Therapy ◽

Waiting List ◽

Controlled Study ◽

Control Group ◽

Control Groups ◽

And Control ◽

To Receive ◽

Experimental Group ◽

Mindfulness Therapy

Background: There are already several existing studies that show the effectiveness of mindfulness-based approaches in varying types of disorders. Only a few studies, however, have analyzed the effectiveness of this intervention in psychosis, and without finding, up to now, significant differences from the control group. Aims: The aim of this study is two-fold: to replicate previous studies, and to focus on analyzing the feasibility and effectiveness of applying mindfulness in a group of people with psychosis. Method: Eighteen patients with psychosis were randomly assigned to experimental and control groups. The experimental group received eight 1-hour sessions of Mindfulness-Based Cognitive Therapy (MBCT), while the control group was relegated to a waiting list to receive MBCT therapy. Results: The experimental group scored significantly higher than the control group in their ability to respond mindfully to stressful internal events. Conclusions: Both the usefulness and effectiveness of implementing a mindfulness-based program have been replicated in a controlled manner in patients with psychosis.

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