scholarly journals Essential Role of Bone Marrow Fibroblast Growth Factor-2 in the Effect of Estradiol on Reendothelialization and Endothelial Progenitor Cell Mobilization

2006 ◽  
Vol 169 (5) ◽  
pp. 1855-1862 ◽  
Author(s):  
Vincent Fontaine ◽  
Cédric Filipe ◽  
Nikos Werner ◽  
Pierre Gourdy ◽  
Audrey Billon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Essential Role ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Cell Mobilization

scholarly journals Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes

2016 ◽  
Vol 130 (9) ◽  
pp. 667-681 ◽  
Author(s):  
Szu-Yu Chien ◽  
Chun-Yin Huang ◽  
Chun-Hao Tsai ◽  
Shih-Wei Wang ◽  
Yu-Min Lin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Neutralizing Antibody ◽  
Interleukin 1Β ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

Angiogenesis is an important event in the process of arthritis. Stimulating chondrocytes with IL-1β increased the expression of FGF-2, via the IL-1RI/ROS/AMPK/p38/NF-κB signalling pathway. FGF-2-neutralizing antibody abolished ATDC5-conditional medium-mediated angiogenesis both in vitro and in vivo.

scholarly journals Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2

2021 ◽  
Author(s):  
Carola Sparn ◽  
Eleni Dimou ◽  
Annalena Meyer ◽  
Roberto Saleppico ◽  
Sabine Wegehingel ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Structural Basis ◽  
Limiting Factor ◽  
Fibroblast Growth ◽  
Unconventional Secretion ◽  
Rate Limiting

Fibroblast Growth Factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse sub-classes consisting of syndecans, perlecans, glypicans and others, Glypican-1 (GPC1) is both the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression.

Immunotherapy‐refractory vacuolar myopathy with mucin deposition in scleromyxedema: A possible role of fibroblast growth factor 2

2020 ◽  
Vol 40 (5) ◽  
pp. 492-495 ◽  
Author(s):  
Yuki Yanagihara ◽  
Shintaro Hayashi ◽  
Junpei Koge ◽  
Hiroyuki Honda ◽  
Ryo Yamasaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Vacuolar Myopathy
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