A pilot lifestyle intervention study: effects of an intervention using an activity monitor and Twitter on physical activity and body composition

A 3-year controlled intervention was used to study the influence of physical activity on the plasma lipid and apoprotein profile of 10-year-old Dutch schoolchildren. Twice-a-year measurements were taken of height, weight, body composition (skinfolds), pubertal development (Tanner stages), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), apoproteins A-I and B (immunoturbidimetry), and participation in physical activities. The effect of the intervention was analyzed with a MANOVA. The intervention did not affect the level of the lipids and apoproteins of the boys. In the girls, the intervention led to a smaller increase of TG and a larger decrease of apoprotein A-I. There may be two explanations for the limited intervention effect. First, it may be due to the healthy baseline plasma lipid and apoprotein profile, which leaves little room for improvement. Second, the exercise intensity during the physical education classes may have been too low to bring about the desired effect.

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The Effect of Changes in Physical Activity on Sedentary Behavior: Results From a Randomized Lifestyle Intervention Trial

American Journal of Health Promotion ◽

10.4278/ajhp.150129-quan-693 ◽

2015 ◽

Vol 31 (4) ◽

pp. 287-295 ◽

Cited By ~ 7

Author(s):

Juned Siddique ◽

Peter John de Chavez ◽

Lynette L. Craft ◽

Patty Freedson ◽

Bonnie Spring

Keyword(s):

Physical Activity ◽

Sedentary Behavior ◽

Lifestyle Intervention ◽

Screen Time ◽

Financial Incentives ◽

Intervention Study ◽

Intervention Trial ◽

Linear Mixed Effects ◽

Chicago Area ◽

Daily Changes

Purpose. To investigate whether changes in physical activity (PA) have an impact on sedentary behavior (SB) during a lifestyle intervention. Design. Study design was a randomized trial. Setting/Subjects. Participants (n = 204) were individuals with low PA and high sedentary leisure screen time from the Chicago area. Intervention. Participants were randomized to either increase PA (iPA) or decrease sedentary leisure (dSED). The intervention consisted of decision support, coaching, and financial incentives. For iPA participants, the goal was at least 60 min/d of self-reported moderate-tovigorous-intensity PA (MVPA). For dSED participants the goal was less than 90 min/d of sedentary leisure screen time. Measures. Daily accelerometer-based measures of SB and bout-corrected MVPA were obtained. Analysis. Linear mixed-effects models were fit to estimate the effect of the intervention on MVPA and total SB and to estimate the effect of daily changes in MVPA on daily SB. Results. The iPA participants increased their bout-corrected MVPA by 14 min/d (p < .001) and decreased their total SB by 18 min/d (p < .001). The dSED participants did not significantly change their PA or their total SB. On days when participants exercised, each 10-minute bout of MVPA was associated with a 6-minute decrease in SB on the same day (p < .001). Conclusion. In an intervention study designed to increase MVPA, participants who increase their time spent exercising will obtain much of this time by reducing their SB.

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Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2009.00379.x ◽

2009 ◽

Vol 21 (3) ◽

pp. 133-140 ◽

Cited By ~ 2

Author(s):

K Doudney ◽

JA Harley ◽

JF Pearson ◽

A Miller ◽

A Aitchison ◽

...

Keyword(s):

Body Composition ◽

Weight Gain ◽

Lifestyle Intervention ◽

Intervention Study ◽

Bioinformatic Analysis ◽

Protein Product ◽

Average Weight ◽

Carnitine Supplementation ◽

Significant Treatment ◽

Bipolar Patients

Background:The protein product of INSIG2 is involved in cholesterol and triglyceride metabolism and homeostasis. Variation at rs7566605 near the gene INSIG2 has been associated with increased BMI.Objective:To evaluate the effect of rs7566605/INSIG2 genotype on the ability of valproate-treated bipolar patients (BMI ≥ 25 kg/m2) to lose weight using carnitine supplementation during a 26-week lifestyle intervention study.Design:Forty-eight bipolar patients with clinically significant treatment emergent weight gain were genotyped at the rs7566605 SNP. Participants were randomised to l-carnitine (15 mg/kg/day) or placebo for 26 weeks in conjunction with a moderately energy restricted, low-fat diet. Weight and body fat percent were measured fortnightly. Waist circumference measurements and dual-energy X-ray absorptiometry were used to assess changes in body composition. Obesity-related biomarkers were measured at baseline and 26 weeks.Results:There was a significant interaction between rs7566605/INSIG2 genetic status and treatment with carnitine or placebo. Carnitine had no significant effect on body composition measures in G allele homozygous patients who lost between 0.97 and 2.23 kg of fat. However C allele carriers on average gained 2.28 kg when given a placebo. Carnitine supplementation in this group enabled average weight loss of 2.22 kg of fat (p = 0.01). Approximately half of this mass was in the vital truncal compartment (p = 0.002). Bioinformatic analysis detected that the SNP lies in a highly conserved 336 bp sequence which potentially affects INSIG2 gene expression.Conclusions:C-carriers at rs7566605, possibly regulating the homeostasis gene INSIG2, lost significantly less weight in this lifestyle intervention study. This effect was reversed by carnitine supplementation.

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Effects of a lifestyle intervention using an activity monitor with game functions on physical activity-A randomized crossover study-

Japanese Journal of Physical Fitness and Sports Medicine ◽

10.7600/jspfsm.61.335 ◽

2012 ◽

Vol 61 (3) ◽

pp. 335-341 ◽

Cited By ~ 2

Author(s):

Masato Nishiwaki ◽

Akinori Kuriyama ◽

Yumi Ikegami ◽

Nana Nakashima ◽

Naoyuki Matsumoto

Keyword(s):

Physical Activity ◽

Crossover Study ◽

Lifestyle Intervention ◽

Activity Monitor ◽

Randomized Crossover Study

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Youth and Young Adult Physical Activity and Body Composition of Young Adult Women: Findings from the Dietary Intervention Study in Children

Pediatric Exercise Science ◽

10.1123/pes.2014-0001 ◽

2015 ◽

Vol 27 (1) ◽

pp. 140-150

Author(s):

Melissa Hodge ◽

Mary Hovinga ◽

Kelley Gabriel ◽

Linda Snetselaar ◽

John Shepherd ◽

...

Keyword(s):

Physical Activity ◽

Body Composition ◽

Young Adult ◽

Body Fat ◽

Intervention Study ◽

Dietary Intervention ◽

Whole Body ◽

Adult Women ◽

Young Adult Women ◽

Dietary Intervention Study

This study prospectively investigates associations between youth moderate-to-vigorous-intensity physical activity (MVPA) and body composition in young adult women using data from the Dietary Intervention Study in Children (DISC) and the DISC06 Follow-Up Study. MVPA was assessed by questionnaire on 5 occasions between the ages 8 and 18 years and at age 25-29 years in 215 DISC female participants. Using whole body dual-energy x-ray absorptiometry (DXA), overall adiposity and body fat distribution were assessed at age 25-29 years by percent body fat (%fat) and android-to-gynoid (A:G) fat ratio, respectively. Linear mixed effects models and generalized linear latent and mixed models were used to assess associations of youth MVPA with both outcomes. Young adult MVPA, adjusted for other young adult characteristics, was significantly inversely associated with young adult %fat (%fat decreased from 37.4% in the lowest MVPA quartile to 32.8% in the highest (p-trend = 0.02)). Adjusted for youth and young adult characteristics including young adult MVPA, youth MVPA also was significantly inversely associated with young adult %fat (β=-0.40 per 10 MET-hrs/wk, p = .02) . No significant associations between MVPA and A:G fat ratio were observed. Results suggest that youth and young adult MVPA are important independent predictors of adiposity in young women.

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