Relationship between vitamin D levels and oxidative stress indicators and related inflammatory factors in patients with polycystic ovary syndrome

2020 ◽  
Author(s):  
Hongzhen Shi ◽  
Tongli Wang ◽  
Qian Wang ◽  
Lin Lin ◽  
Zhirui Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Inflammatory Factors ◽  
Ovary Syndrome ◽  
Stress Indicators ◽  
Vitamin D Levels ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

scholarly journals Relationship between parasympathetic reactivity and oxidative stress in Polycystic ovary syndrome

2020 ◽  
Vol 14 (2) ◽  
pp. 48-55
Author(s):  
Ayesha Akhter ◽  
Sultana Ferdousi ◽  
Shamima Sultana ◽  
Musfika Mostafa
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Regression Analysis ◽  
Polycystic Ovary Syndrome ◽  
Multiple Regression Analysis ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Healthy Control ◽  
And Oxidative Stress ◽  
Plasma Malondialdehyde

Background: Polycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder. Altered cardiovagal autonomic modulation and oxidative stress may predispose PCOS patients to increased cardiovascular morbidity. Objective: To assess the relationship between parasympathetic reactivity and oxidative stress in patients with PCOS. Methods: This crosssectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy women were also enrolled as control. Three noninvasive conventional autonomic function tests, such as heart rate response to deep breathing, standing and the Valsalva maneuver, were used for evaluation of parasympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level (oxidant) and plasma catalase level(antioxidant) were measured in all subjects by spectrophotometry. Data were expressed as mean± SD. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done as applicable. Results: In this study PCOS patients had significantly higher (p<0.01)resting heart rate, systolic and diastolic blood pressure than that of healthy control. But Expiration: Inspiration ratio, Expiration:Inspiration difference and 30:15 ratio during standing were significantly lower (p<0.001, p<0.01 and p<0.05 respectively) in PCOS compared to control. In addition, plasma catalase level was significantly lower (p<0.01)and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. Multiple regression analysis showed plasma catalase as a significant positive predictor (p<0.05) of the Valsalva ratio in PCOS. Also, Valsalva ratio showed significant negative association (p<0.05) with plasma malondialdehyde (p<0.01)in PCOS. Conclusion: Based on these results it is concluded that impaired parasympathetic reactivity showed inverse relationship with oxidative stress in PCOS. J Bangladesh Soc Physiol. 2019, December; 14(2): 48-55

scholarly journals Associations between vitamin D levels and polycystic ovary syndrome phenotypes

2019 ◽  
Vol 44 (2) ◽  
Author(s):  
Erin M. Davis ◽  
Jennifer D. Peck ◽  
Karl R. Hansen ◽  
Barbara R. Neas ◽  
LaTasha B. Craig
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Vitamin D Levels

scholarly journals Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Iman Abdullah Bindayel
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Triglyceride ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Hydroxyvitamin D ◽  
Saudi Women ◽  
Number Of Patients ◽  
Vitamin D Levels

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p &lt; 0.05), a significantly higher rate of obesity (p &lt; 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p &lt; 0.05) and exposed to sun (p &lt; 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

Sign in / Sign up

Export Citation Format

Share Document