Genetic and environmental factors influencing the interaction between the gut microbiota and the human host: implications for gastrointestinal disorders and treatment approaches

Author(s):  
Erika Meaddough ◽  
Ludovico Abenavoli ◽  
Sara Sarasua ◽  
Luigi Boccuto
2005 ◽  
Vol 90 (7) ◽  
pp. 4170-4176 ◽  
Author(s):  
Nancy F. Butte ◽  
Anthony G. Comuzzie ◽  
Gouwen Cai ◽  
Shelley A. Cole ◽  
Nitesh R. Mehta ◽  
...  

2019 ◽  
Vol 22 ◽  
pp. S9-S10
Author(s):  
I. Kouw ◽  
I. Levinger ◽  
N. Eynon ◽  
E. Parr ◽  
S. Iuliano

2019 ◽  
Vol 2 (1) ◽  

Until quite recently, diagnostic imaging has relied upon “qualitative” imaging limited by the ability to define disease as either present or absent. The first marker that you are using a “qualitative” test is a discussion of sensitivity, the ability to find disease when present and specificity, the ability to exclude disease when absent [1-9]. This yes/no approach to medicine reflects the limitations qualitatively imposed upon us despite the understanding that tissues don’t simply exist in either a “normal” or “diseased” state but rather a transition occurs as the genetic and environmental factors influencing tissues results in transitional changes, transitional changes which can now be fully appreciated and measured [1-9].


2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Haseeb Anwar ◽  
Arslan Iftikhar ◽  
Humaira Muzaffar ◽  
Ahmad Almatroudi ◽  
Khaled S. Allemailem ◽  
...  

Human bodies encompass very important symbiotic and mutualistic relationships with tiny creatures known as microbiota. Trillions of these tiny creatures including protozoa, viruses, bacteria, and fungi are present in and on our bodies. They play important roles in various physiological mechanisms of our bodies. In return, our bodies provide them with the habitat and food necessary for their survival. In this review, we comprehend the gut microbial species present in various regions of the gut. We can get benefits from microbiota only if they are present in appropriate concentrations, as if their concentration is altered, it will lead to dysbiosis of microbiota which further contributes to various health ailments. The composition, diversity, and functionality of gut microbiota do not remain static throughout life as they keep on changing over time. In this review, we also reviewed the various biotic and abiotic factors influencing the quantity and quality of these microbiota. These factors serve a significant role in shaping the gut microbiota population.


2004 ◽  
Vol 56 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Jorge Esparza-Gordillo ◽  
Jos� Manuel Soria ◽  
Alfonso Buil ◽  
Laura Almasy ◽  
John Blangero ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Kang Li ◽  
Wei Peng ◽  
Youlian Zhou ◽  
Yi Ren ◽  
Jianhua Zhao ◽  
...  

The human gut microbiota is affected by genetic and environmental factors. It remains unclear how host genetic and environmental factors affect the composition and function of gut microbiota in populations living at high altitudes. We used a metagenome-wide analysis to investigate the gut microbiota composition in 15 native Tibetans and 12 Hans living on the Tibetan Plateau. The composition of gut microbiota differed significantly between these two groups (P<0.05). The Planctomycetes was the most abundant phyla both in native Tibetans and in Hans. Furthermore, the most relatively abundant phyla for native Tibetans were Bacteroidetes (15.66%), Firmicutes (11.10%), Proteobacteria (1.32%), Actinobacteria (1.10%), and Tenericutes (0.35%), while the most relatively abundant phyla for Hans were Bacteroidetes (16.28%), Firmicutes (8.41%), Proteobacteria (2.93%), Actinobacteria (0.49%), and Cyanobacteria (0.21%). The abundance of the majority of genera was significantly higher in Tibetans than in Hans (P<0.01). The number of microbial genes was 4.9 times higher in Tibetans than in Hans. The metabolic pathways and clusters of orthologous groups differed significantly between the two populations (P<0.05). The abundance of carbohydrate-active enzyme modules and antibiotic resistance genes was significantly lower in Tibetans compared to Hans (P<0.05). Our results suggest that different genetic factors (race) and environmental factors (diets and consumption of antibiotics) may play important roles in shaping the composition and function of gut microbiota in populations living at high altitudes.


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