scholarly journals Concussão Cerebral no Judo – Programa de Retorno ao Treino e Competição

2021 ◽  
Vol 12 (1) ◽  
pp. 20-23
Author(s):  
Vítor Silva ◽  
◽  
Marcos Carvalho ◽  
Bruno Carvalho ◽  
◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Clinical Severity ◽  
Imaging Studies ◽  
Orientation Program ◽  
Cerebral Concussion ◽  
Therapeutic Behavior ◽  
Specific Orientation

Cerebral concussion consists in a complex traumatic brain injury with functional repercussion, which occurs after a direct or indirect brain trauma, without abnormalities identified in imaging studies. The increasing prevalence of this injury in judo, its clinical severity and the general unawareness of the best therapeutic behavior were the necessary stimulus to conduct a specific orientation program for the sport. These procedures will allow a safe return to train and competition ensuring the athlete’s physical and cognitive integrity.

scholarly journals Pathologically Entangled: Brain trauma-evoked ROS imbalance disrupts Kir channel function in distant peripheral vessels

Function ◽  
2021 ◽  
Author(s):  
Nick Weir ◽  
Thomas A Longden
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Potassium Channels ◽  
Vascular Function ◽  
Inward Rectifier ◽  
Brain Trauma ◽  
Channel Function ◽  
Inward Rectifier Potassium Channels ◽  
Kir Channel

Abstract A Perspective on "Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels"

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 581-594 ◽  
Author(s):  
Megan Browning ◽  
Deborah A. Shear ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Stefania Mondello ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study

2019 ◽  
Vol 36 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Zhihui Yang ◽  
Tian Zhu ◽  
Stefania Mondello ◽  
Miis Akel ◽  
Aaron T. Wong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

The Role of Inflammation in Traumatic Brain Injury

Neurotrauma ◽  
2018 ◽  
pp. 211-232
Author(s):  
Sarah C. Hellewell ◽  
Bridgette D. Semple ◽  
Jenna M. Ziebell ◽  
Nicole Bye ◽  
Cristina Morganti-Kossmann
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glial Cells ◽  
Immune Cell ◽  
Brain Trauma ◽  
Multiple Roles ◽  
Cell Functions ◽  
Macrophage Populations

Inflammation occurring following brain trauma represents a significant constituent of complex secondary responses that dictate patients’ outcome. Although a few decades have passed since its discovery, new aspects of this intriguing phenomenon are still being uncovered, ranging from the multiple roles of mediators regulating the inception, progression, and resolution of neuroinflammation, to the development of antiinflammatory therapies. This review provides a summary of the vast research on traumatic brain injury inflammation. The authors describe the fundamental aspects of cytokine and immune cell functions, the orchestrated collaboration of chemokines and leukocytes, the phenotypic distinction of macrophage populations, and the contribution of glial cells. Among the beneficial properties of neuroinflammation, they briefly discuss cytokines’ impact on neurogenesis; the chapter concludes by touching on the implications of antiinflammatory therapies.

scholarly journals Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Rita Campos-Pires ◽  
Haldis Onggradito ◽  
Eszter Ujvari ◽  
Shughoofa Karimi ◽  
Flavia Valeo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Functional Outcome ◽  
Neuroprotective Effect ◽  
Neuronal Loss ◽  
Brain Trauma ◽  
Lesion Volume ◽  
Oxygen Balance ◽  
Sprague Dawley ◽  
Locomotor Deficits

Abstract Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we evaluate the effect of xenon treatment on functional outcome, lesion volume, neuronal loss and neuroinflammation after severe TBI in rats. Methods Young adult male Sprague Dawley rats were subjected to controlled cortical impact (CCI) brain trauma or sham surgery followed by treatment with either 50% xenon:25% oxygen balance nitrogen, or control gas 75% nitrogen:25% oxygen. Locomotor function was assessed using Catwalk-XT automated gait analysis at baseline and 24 h after injury. Histological outcomes were assessed following perfusion fixation at 15 min or 24 h after injury or sham procedure. Results Xenon treatment reduced lesion volume, reduced early locomotor deficits, and attenuated neuronal loss in clinically relevant cortical and subcortical areas. Xenon treatment resulted in significant increases in Iba1-positive microglia and GFAP-positive reactive astrocytes that was associated with neuronal preservation. Conclusions Our findings demonstrate that xenon improves functional outcome and reduces neuronal loss after brain trauma in rats. Neuronal preservation was associated with a xenon-induced enhancement of microglial cell numbers and astrocyte activation, consistent with a role for early beneficial neuroinflammation in xenon’s neuroprotective effect. These findings suggest that xenon may be a first-line clinical treatment for brain trauma.

scholarly journals Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 567-580 ◽  
Author(s):  
Andrea Mountney ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Stefania Mondello ◽  
W. Dalton Dietrich ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy ◽  
Simvastatin Treatment

The Adam Williams Initiative: Collaborating With Community Resources to Improve Care for Traumatic Brain Injury

2014 ◽  
Vol 34 (6) ◽  
pp. 39-47 ◽  
Author(s):  
Mary Kay Bader ◽  
Sonja E. Stutzman ◽  
Sylvain Palmer ◽  
Chiedozie I. Nwagwu ◽  
Gary Goodman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Treatment Guidelines ◽  
The United States ◽  
Brain Trauma ◽  
Successful Implementation ◽  
Team Members ◽  
Staff Members ◽  
Brain Trauma Foundation ◽  
The Brain

Background The Brain Trauma Foundation has developed treatment guidelines for the care of patients with acute traumatic brain injury. However, a method to provide broad acceptance and application of these guidelines has not been published. Objective To describe methods for the development, funding, and continued educational efforts of the Adam Williams Initiative; the experiences from the first 10 years may serve as a template for hospitals and nurses that seek to engage in long-term quality improvement collaborations with foundations and/or industry. Methods In 2004, the nonprofit Adam Williams Initiative was established with the goal of providing education and resources that would encourage hospitals across the United States to incorporate the Brain Trauma Foundation’s guidelines into practice. Results Between 2004 and 2014, 37 hospitals have been funded by the Adam Williams Initiative and have had staff members participate in an immersion experience at Mission Hospital (Mission Viejo, California) during which team members received both didactic and hands-on education in the care of traumatic brain injury. Conclusions Carefully cultivated relationships and relentless teamwork have contributed to successful implementation of the Brain Trauma Foundation’s guidelines in US hospitals.

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