Faculty Opinions recommendation of Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity.

2019 ◽  
Author(s):  
Gregory Hawryluk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Severity ◽  
Prognostic Information

The Role of Neuroimaging in Assessing Neuropsychological Deficits following Traumatic Brain Injury

2011 ◽  
Vol 39 (4) ◽  
pp. 537-566 ◽  
Author(s):  
Benjamin J. Hayempour ◽  
Susan E. Rushing ◽  
Abass Alavi
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Damage ◽  
Brain Injuries ◽  
Neuropsychological Deficits ◽  
Prognostic Information ◽  
Specific Identification ◽  
Secondary Damage ◽  
Neuroimaging Techniques

Neuroimaging enables highly accurate and specific identification of treatable brain injuries for the purposes of preventing secondary damage as well as providing useful prognostic information. This article addresses the range of currently employed neuroimaging techniques and their utility in assessing legal claims involving the presence of brain damage.

Magnetic resonance imaging of traumatic brain injury: relationship of T2 SE and T2*GE to clinical severity and outcome

Brain Injury ◽  
2004 ◽  
Vol 18 (11) ◽  
pp. 1083-1097 ◽  
Author(s):  
Donald J. Gerber ◽  
Alan H. Weintraub ◽  
Christopher P. Cusick ◽  
Peter E. Ricci ◽  
Gale G. Whiteneck
Keyword(s):  
Magnetic Resonance Imaging ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Magnetic Resonance ◽  
Clinical Severity ◽  
Resonance Imaging ◽  
Relationship Of

Metabolic brain changes detected by 1H-MRSI are relevant to clinical severity and outcome in traumatic brain injury

2005 ◽  
Vol 22 (Supplement 36) ◽  
pp. 22
Author(s):  
S. Marino ◽  
E. Zei ◽  
M. Battaglini ◽  
C. Vittori ◽  
P. Bramanti ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Severity ◽  
Brain Changes

scholarly journals Letter to the Editor. Simplifying the use of prognostic information in patients with traumatic brain injury

2018 ◽  
Vol 129 (3) ◽  
pp. 847-849
Author(s):  
Davi J. Fontoura Solla ◽  
Manoel Jacobsen Teixeira ◽  
Wellingson Silva Paiva
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Prognostic Information ◽  
Letter To The Editor

scholarly journals Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome

2006 ◽  
Vol 78 (5) ◽  
pp. 501-507 ◽  
Author(s):  
S. Marino ◽  
E. Zei ◽  
M. Battaglini ◽  
C. Vittori ◽  
A. Buscalferri ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Severity ◽  
Brain Changes

scholarly journals Circulating Brain Injury Exosomal Proteins following Moderate-to-Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 977 ◽  
Author(s):  
Stefania Mondello ◽  
Vivian A. Guedes ◽  
Chen Lai ◽  
Endre Czeiter ◽  
Krisztina Amrein ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Single Molecule ◽  
Tau Proteins ◽  
Clinical Implementation ◽  
Focal Lesions ◽  
Prognostic Information ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Severe Tbi

Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal trajectories of brain injury exosomal proteins in blood of patients with moderate-to-severe TBI, and to evaluate the relation with the free-circulating counterpart and patient imaging and clinical parameters. Exosomal levels of glial (glial fibrillary acidic protein (GFAP)) and neuronal/axonal (ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), neurofilament light chain (NFL), and total-tau (t-tau)) proteins were measured in serum of 21 patients for up 5 days after injury using single molecule array (Simoa) technology. Group-based trajectory analysis was used to generate distinct temporal exosomal biomarker profiles. We found altered profiles of serum brain injury exosomal proteins following injury. The dynamics and levels of exosomal and related free-circulating markers, although correlated, showed differences. Patients with diffuse injury displayed higher acute exosomal NFL and GFAP concentrations in serum than those with focal lesions. Exosomal UCH-L1 profile characterized by acutely elevated values and a secondary steep rise was associated with early mortality (n = 2) with a sensitivity and specificity of 100%. Serum brain injury exosomal proteins yielded important diagnostic and prognostic information and represent a novel means to unveil underlying pathophysiology in patients with moderate-to-severe TBI. Our findings support their utility as potential tools to improve patient phenotyping in clinical practice and therapeutic trials.

scholarly journals Concussão Cerebral no Judo – Programa de Retorno ao Treino e Competição

2021 ◽  
Vol 12 (1) ◽  
pp. 20-23
Author(s):  
Vítor Silva ◽  
◽  
Marcos Carvalho ◽  
Bruno Carvalho ◽  
◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Clinical Severity ◽  
Imaging Studies ◽  
Orientation Program ◽  
Cerebral Concussion ◽  
Therapeutic Behavior ◽  
Specific Orientation

Cerebral concussion consists in a complex traumatic brain injury with functional repercussion, which occurs after a direct or indirect brain trauma, without abnormalities identified in imaging studies. The increasing prevalence of this injury in judo, its clinical severity and the general unawareness of the best therapeutic behavior were the necessary stimulus to conduct a specific orientation program for the sport. These procedures will allow a safe return to train and competition ensuring the athlete’s physical and cognitive integrity.

Prognostic significance of blood-brain barrier disruption in patients with severe nonpenetrating traumatic brain injury requiring decompressive craniectomy

2014 ◽  
Vol 121 (3) ◽  
pp. 674-679 ◽  
Author(s):  
Kwok M. Ho ◽  
Stephen Honeybul ◽  
Cheng B. Yip ◽  
Benjamin I. Silbert
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Decompressive Craniectomy ◽  
Prognostic Value ◽  
Prognostic Model ◽  
Long Term Outcomes ◽  
Prognostic Information ◽  
Severe Tbi

Object The authors assessed the risk factors and outcomes associated with blood-brain barrier (BBB) disruption in patients with severe, nonpenetrating, traumatic brain injury (TBI) requiring decompressive craniectomy. Methods At 2 major neurotrauma centers in Western Australia, a retrospective cohort study was conducted among 97 adult neurotrauma patients who required an external ventricular drain (EVD) and decompressive craniectomy during 2004–2012. Glasgow Outcome Scale scores were used to assess neurological outcomes. Logistic regression was used to identify factors associated with BBB disruption, defined by a ratio of total CSF protein concentrations to total plasma protein concentration > 0.007 in the earliest CSF specimen collected after TBI. Results Of the 252 patients who required decompressive craniectomy, 97 (39%) required an EVD to control intracranial pressure, and biochemical evidence of BBB disruption was observed in 43 (44%). Presence of disruption was associated with more severe TBI (median predicted risk for unfavorable outcome 75% vs 63%, respectively; p = 0.001) and with worse outcomes at 6, 12, and 18 months than was absence of BBB disruption (72% vs 37% unfavorable outcomes, respectively; p = 0.015). The only risk factor significantly associated with increased risk for BBB disruption was presence of nonevacuated intracerebral hematoma (> 1 cm diameter) (OR 3.03, 95% CI 1.23–7.50; p = 0.016). Although BBB disruption was associated with more severe TBI and worse long-term outcomes, when combined with the prognostic information contained in the Corticosteroid Randomization after Significant Head Injury (CRASH) prognostic model, it did not seem to add significant prognostic value (area under the receiver operating characteristic curve 0.855 vs 0.864, respectively; p = 0.453). Conclusions Biochemical evidence of BBB disruption after severe nonpenetrating TBI was common, especially among patients with large intracerebral hematomas. Disruption of the BBB was associated with more severe TBI and worse long-term outcomes, but when combined with the prognostic information contained in the CRASH prognostic model, this information did not add significant prognostic value.

Computed tomography characteristics in pediatric versus adult traumatic brain injury

2014 ◽  
Vol 13 (3) ◽  
pp. 307-314 ◽  
Author(s):  
Korak Sarkar ◽  
Krista Keachie ◽  
UyenThao Nguyen ◽  
J. Paul Muizelaar ◽  
Marike Zwienenberg-Lee ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pediatric Patients ◽  
Clinical Care ◽  
Pediatric Trauma ◽  
Adult Patients ◽  
Clinical Severity ◽  
Ct Findings ◽  
Severity Of Injury ◽  
Pediatric Tbi

Object Traumatic brain injury (TBI) is a leading cause of injury, hospitalization, and death among pediatric patients. Admission CT scans play an important role in classifying TBI and directing clinical care, but little is known about the differences in CT findings between pediatric and adult patients. The aim of this study was to determine if radiographic differences exist between adult and pediatric TBI. Methods The authors retrospectively analyzed TBI registry data from 1206 consecutive patients with nonpenetrating TBI treated at a Level 1 adult and pediatric trauma center over a 30-month period. Results The distribution of sex, race, and Glasgow Coma Scale (GCS) score was not significantly different between the adult and pediatric populations; however, the distribution of CT findings was significantly different. Pediatric patients with TBI were more likely to have skull fractures (OR 3.21, p < 0.01) and epidural hematomas (OR 1.96, p < 0.01). Pediatric TBI was less likely to be associated with contusion, subdural hematoma, subarachnoid hemorrhage, or compression of the basal cisterns (p < 0.05). Rotterdam CT scores were significantly lower in the pediatric population (2.3 vs 2.6, p < 0.001). Conclusions There are significant differences in the CT findings in pediatric versus adult TBI, despite statistical similarities with regard to clinical severity of injury as measured by the GCS. These differences may be due to anatomical characteristics, the biomechanics of injury, and/or differences in injury mechanisms between pediatric and adult patients. The unique characteristics of pediatric TBI warrant consideration when formulating a clinical trial design or predicting functional outcome using prognostic models developed from adult TBI data.

Sign in / Sign up

Export Citation Format

Share Document