Association of Growth Differentiation Factor 5 (GDF5) Gene Polymorphisms with Susceptibility to Knee Osteoarthritis in Saudi Population

AbstractBackgroundA great deal of evidence has supported that growth differentiation factor 5 (GDF5) is associated with the occurrence of knee osteoarthritis (KOA), while their results are not consistent. In the present study, we aimed to explore the association between GDF5 gene polymorphism and KOA for a more credible conclusion.MethodsComprehensive literature searches were carried out in English databases, including PubMed, Embase, Web of Science (WOS), and Cochrane, and Chinese databases, including China National Knowledge Infrastructure (CNKI), WANFANG, and VIP database. After the data were extracted from the required studies, the odds ratios (ORs) and their 95% confidence intervals (CIs) were determined to assess the correlation between GDF5 gene polymorphism and KOA. The publication bias was evaluated by funnel plot.ResultsAccording to the inclusion and exclusion criteria, 15 studies on the correlation between GDF5 gene polymorphism and KOA occurrence were eligible for meta-analysis. Among these articles, four studies showed no apparent correlation, while the other 11 studies indicated an obvious correlation. Meanwhile, we also carried out a subgroup analysis of the population. Due to the inevitable heterogeneity, three genetic models were finally selected for analysis. With the allele model (C versus T: OR = 0.79, 95% CI = 0.73~0.87), recessive model (CC versus CT + TT: OR = 0.76, 95% CI = 0.68~0.86), and homozygous model (CC versus TT: OR = 0.66, 95% CI = 0.58~0.76), GDF5 gene polymorphism decreased the risk of KOA. Besides, a significant association was observed in Caucasians, Asians, and Africans. Meanwhile, the protective effect of genotype C (or CC) in the Asian group was little obvious than that in the Caucasian group and the African group. Although the quality of the included studies was above medium-quality, we obtained results with a low level of evidence.ConclusionsThe results of the meta-analysis showed that the genotype C (or CC) of GDF5 protected against KOA occurrence in Caucasian, Asian, and African populations.

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Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Arthritis Research & Therapy ◽

10.1186/s13075-020-02306-9 ◽

2020 ◽

Vol 22 (1) ◽

Author(s):

Lei Peng ◽

Song Jin ◽

Jiping Lu ◽

Chao Ouyang ◽

Jiang Guo ◽

...

Keyword(s):

Genetic Polymorphism ◽

Knee Osteoarthritis ◽

Meta Analysis ◽

Recessive Model ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Differentiation Factor ◽

Model C ◽

Relationship Of ◽

Growth Differentiation Factor 5

Abstract Background A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang library. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software. Results A total of 196 studies were collected, 16 of them included in final meta-analysis (7997 cases and 12,684 controls). There was significant association between GDF5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76–0.91); dominate model (CC+CT versus TT): OR = 0.80 (95% CI = 0.72–0.90); recessive model (CC versus CT+TT): OR = 0.79 (95% CI = 0.68–0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI = 0.80–0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI = 0.60–0.85)). In the subgroup analysis, we obtained the results that there is no significance among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

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The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the greek population

Journal of Orthopaedic Research® ◽

10.1002/jor.20464 ◽

2008 ◽

Vol 26 (1) ◽

pp. 136-140 ◽

Cited By ~ 20

Author(s):

Aspasia Tsezou ◽

Maria Satra ◽

Pagona Oikonomou ◽

Konstantinos Bargiotas ◽

Konstantinos N. Malizos

Keyword(s):

Knee Osteoarthritis ◽

Core Promoter ◽

Promoter Polymorphism ◽

Greek Population ◽

Differentiation Factor ◽

Growth Differentiation Factor 5

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Association Between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis Among Caucasian but Not Asian: A Meta-analysis (PROSPERO CRD42020168180)

10.21203/rs.3.rs-38373/v1 ◽

2020 ◽

Author(s):

peng lei ◽

Song Jin ◽

Jiping Lu ◽

Chao Ouyang ◽

Jiang Gou ◽

...

Keyword(s):

Genetic Polymorphism ◽

Knee Osteoarthritis ◽

Meta Analysis ◽

Recessive Model ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Differentiation Factor ◽

Model C ◽

Relationship Of ◽

Growth Differentiation Factor 5

Abstract Background. A few months ago, the Bioscience Reports journal showed that Growth Differentiation Factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data.Methods. The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang library.Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software. Results. A total of 196 studies were collected, 16 of them including in final meta-analysis (7997 cases and 12684 controls). There was significant association between GDF 5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76-0.91); dominate model (CC+CT versus TT): OR = 0.80(95% CI = (0.72-0.90); recessive model (CC versus CT+TT): OR= 0.79 (95% CI = 0.68-0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI=0.80-0.97 ); homozygous model (CC versus TT): OR = 0.71 (95% CI=0.60-0.85). In the subgroup analysis by ethnicity, we obtained the results is no significant among Asians.Conclusion. GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

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Rs143383 in the Growth Differentiation Factor 5 (GDF5) Gene Significantly Associated with Osteoarthritis (OA)-A Comprehensive Meta-analysis

International Journal of Medical Sciences ◽

10.7150/ijms.5455 ◽

2013 ◽

Vol 10 (3) ◽

pp. 312-319 ◽

Cited By ~ 14

Author(s):

Jie Liu ◽

Wei Cai ◽

Hongxin Zhang ◽

Chuan He ◽

Lianfu Deng

Keyword(s):

Meta Analysis ◽

Differentiation Factor ◽

Growth Differentiation Factor 5 ◽

Gdf5 Gene

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Identification of Mutation in the Growth Differentiation Factor 5 (Gdf5) Gene in NC-brp/brp Mice

Journal of Veterinary Medical Science ◽

10.1292/jvms.68.1121 ◽

2006 ◽

Vol 68 (10) ◽

pp. 1121-1124 ◽

Cited By ~ 4

Author(s):

Jun-ichi SUTO

Keyword(s):

Differentiation Factor ◽

Growth Differentiation Factor 5 ◽

Gdf5 Gene

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Association between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis among Caucasian But Not Asian: A Meta-analysis

10.21203/rs.3.rs-38373/v2 ◽

2020 ◽

Author(s):

peng lei ◽

Song Jin ◽

Jiping Lu ◽

Chao Ouyang ◽

Jiang Gou ◽

...

Keyword(s):

Genetic Polymorphism ◽

Knee Osteoarthritis ◽

Meta Analysis ◽

Case Control ◽

Recessive Model ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Trial Quality ◽

Differentiation Factor ◽

Growth Differentiation Factor 5

Abstract Background A few months ago, the Bioscience Reports journal showed that Growth Differentiation Factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang library. The meta-analysis was completed by STATA 18.0 software. Two independent authors extracted the data and assessed case-control trial quality. Results A total of 196 studies were collected, 16 of them including in final meta-analysis (7997 cases and 12684 controls). There was significant association between GDF 5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76-0.91); dominate model (CC+CT versus TT): OR = 0.80(95% CI = (0.72-0.90); recessive model (CC versus CT+TT): OR= 0.79 (95% CI = 0.68-0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI=0.80-0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI=0.60-0.85). In the subgroup analysis by ethnicity, we obtained the results is no significant among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

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