Effect of Exercise Program on Bone Mineral Density of Lumbar Spine and Femur in Korean Women: A Systematic Review and Meta-Analysis

This systematic review with meta-analysis was conducted to assess the effects of small-sided games (SSG)-based training programs on bone mineral density (BMD) in untrained adults. The data sources utilized were Cochrane, Embase, Medline (PubMed), Scopus, SPORTDiscus, and Web of Science. The study eligibility criteria were: (i) untrained adults (>18 years old) of any sex, with or without a noncommunicable disease; (ii) SSG-based programs with a minimum duration of four weeks and no restrictions regarding frequency (number of sessions per week); (iii) passive or active control groups; (iv) pre-post values of BMD; (v) only randomized controlled trials; and (vi) only original and full-text studies written in English. The database search initially yielded 374 titles. From those, nine articles were eligible for the systematic review and meta-analysis. The age of included population varied from a minimum of 20 and a maximum of 71 years old. Non-significant differences between SSG and passive and active control groups on total BMD (ES = 0.14; p = 0.405 and ES = 0.28; p = 0.05, respectively). Meanwhile, significant differences in favor of SSGs vs. passive and control groups were detected, evidencing an improvement of BMD in lower limbs of the adult population for both sexes (ES = 0.26; p = 0.05 and ES = 0.28; p = 0.156, respectively). As conclusions, SSGs can be used as a non-pharmacological alternative to increase the BMD in the lower limbs despite having no significant impact on total body BMD. Careful generalization should be done of the level of heterogeneity.

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Retraction Note: Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis

Scientific Reports ◽

10.1038/s41598-021-88654-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Liang Zhang ◽

Xin Yin ◽

Jingcheng Wang ◽

Daolinag Xu ◽

Yongxiang Wang ◽

...

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Postmenopausal Women ◽

Bone Mineral ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Mineral Density ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Osteoporosis Risk

Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-88654-1.

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Is denosumab associated with an increased risk for infection in patients with low bone mineral density? A systematic review and meta‐analysis of randomized controlled trials

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.14101 ◽

2021 ◽

Author(s):

Brett Catton ◽

Salman Surangiwala ◽

Tanveer Towheed

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Randomized Controlled Trials ◽

Bone Mineral ◽

Meta Analysis ◽

Controlled Trials ◽

Mineral Density ◽

Randomized Controlled ◽

Low Bone Mineral Density ◽

Increased Risk

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The Effect of Calcium or Calcium and Vitamin D Supplementation on Bone Mineral Density in Healthy Males: A Systematic Review and Meta-Analysis

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.2014-0202 ◽

2015 ◽

Vol 25 (5) ◽

pp. 510-524 ◽

Cited By ~ 16

Author(s):

Leslie N. Silk ◽

David A. Greene ◽

Michael K. Baker

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Vitamin D ◽

Lumbar Spine ◽

Calcium Supplementation ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Mineral Density ◽

Total Body ◽

Healthy Males

Research examining the preventative effects of calcium and vitamin D supplementation has focused on children and females, leaving the effects on male bone mineral density (BMD) largely unexplored. Thus, the aim of this systematic review and meta-analysis is to examine the efficacy of calcium supplementation, with or without vitamin D for improving BMD in healthy males. Medline, EMBASE, SPORTDiscus, Academic Search Complete, CINHAHL Plus and PubMed databases were searched for studies including healthy males which provided participants calcium supplementation with or without vitamin D and used changes to BMD as the primary outcome measure. Between trial standardized mean differences of percentage change from baseline in BMD of femoral neck, lumbar spine, total body and total hip sites were calculated. Nine studies were included in the systematic review with six references totaling 867 participants contributing to the meta-analysis. Significant pooled effects size (ES) for comparison between supplementation and control groups were found at all sites included in the meta-analysis. The largest effect was found in total body (ES = 0.644; 95% CI = 0.406–0.883; p < .001), followed by total hip (ES = 0.483, 95% CI= 0.255–0.711, p < .001), femoral neck (ES = 0.402, 95% CI = 0.233–0.570, p = .000) and lumbar spine (ES = 0.306, 95% CI = 0.173–0.440, p < .001). Limited evidence appears to support the use of calcium and vitamin D supplementation for improving BMD in older males. There is a need for high quality randomized controlled trials, especially in younger and middle-aged male cohorts and athletic populations to determine whether supplementation provides a preventative benefit.

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Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis

10.2337/figshare.14618409 ◽

2021 ◽

Author(s):

Phoebe Loxton ◽

Kruthika Narayan ◽

Craig F Munns ◽

Maria E Craig

Keyword(s):

Bone Mineral Density ◽

Type 1 Diabetes ◽

Lumbar Spine ◽

Bone Mineral ◽

Meta Analysis ◽

Inclusion Criteria ◽

Mineral Density ◽

Multiple Modalities ◽

Meta Regression

Background There is substantial evidence that adults with type 1 diabetes have reduced bone mineral density (BMD), however findings in youth are inconsistent. Purpose Systematic review and meta-analysis of BMD in youth with type 1 diabetes using multiple modalities: dual energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and/or quantitative ultrasound (QUS). Data Sources PubMed, Embase, Scopus and Web of Science from 01/01/1990 to 31/12/2020, limited to humans, without language restriction. Study Selection Inclusion criteria: cross sectional or cohort studies that included BMD measured either by DXA, pQCT and/or QUS in youth (age <20 years) with type 1 diabetes and matched controls. Data extraction Total body (TB), lumbar spine (LS) and femoral BMD (DXA); tibia, radius and lumbar spine (pQCT); and phalanx and calcaneum (QUS). Weighted mean difference (WMD) or standardized mean difference (SMD) were estimated and meta-regression was performed using age, diabetes duration and HbA1c as covariates. Data Synthesis We identified 1300 non-duplicate studies; 46 met the inclusion criteria, including 2617 cases and 3851 controls. Mean age was 12.6 ± 2.3 years. Youth with type 1 diabetes had lower BMD: TB (WMD -0.04 g/cm2, 95% CI -0.06 to -0.02, P=0.0006); LS (-0.02 g/cm2, -0.03 to -0.0, P = 0.01); femur (-0.04 g/cm2, -0.05 to -0.03, P<0.00001); tibial trabecular (-11.32 g/cm3,-17.33 to -5.30, P=0.0002), radial trabecular (-0.91, -1.55 to -0.27, P=0.005); phalangeal (-0.32, -0.38 to -0.25, P<0.00001) and calcaneal (SMD -0.69, -1.11 to -0.26, P=0.001). Using meta-regression TB BMD was associated with older age (coefficient -0.0063, -0.0095 to -0.0031, P=0.002), but not longer diabetes duration or HbA1c. Limitations Meta-analysis was limited by the small number of studies using QUS and pQCT and lack of use BMD z-scores in all studies. Conclusions Bone development is abnormal in youth with type 1 diabetes, assessed by multiple modalities. Routine assessment of BMD should be considered in all youth with type 1 diabetes.

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