Choroid plexus papilloma in a free ranging eared dove (Zenaida auriculata)

Choroid plexus tumors (CPT) are rare neoplasms and histologically classified as choroid plexus papilloma (CPP), atypical choroid plexus papilloma (APP), and choroid plexus carcinoma (CPC). These neoplasms have been described in humans, domestic animals (canine, feline, equine, caprine) and some wild animals (cetaceans and Psittacidae birds). To our best knowledge, herein we report the first CCP in a free-ranging eared dove (Columbiformes; Zenaida auriculata, de Murs 1847). Histologically, the ventricle was dilated, with a papillary proliferation (arboriform pattern) in topography of CP. The neoplasm was well-differentiated, composed by a single layer of cuboidal cells, anchored in a delicate fibrovascular stroma. The neoplastic cells exhibited moderate stroma, with well-defined borders and round nuclei, with vesicular chromatin and inconspicuous nucleoli. Mitotic activity was low (<1 mitosis per 10 high-power fields). Immunohistochemistry for cytokeratin markers (AE1/AE3 antibody) were implemented, however, both neoplastic cells and normal epithelial tissues do not show immunoreactivity.

Download Full-text

Choroid Plexus Papilloma in a Dog

Veterinary Pathology ◽

10.1177/030098587100800110 ◽

1971 ◽

Vol 8 (1) ◽

pp. 91-95 ◽

Cited By ~ 12

Author(s):

H. J. Kurtz ◽

Griselda F. Hanlon

Keyword(s):

Choroid Plexus ◽

Fourth Ventricle ◽

Choroid Plexus Papilloma ◽

Clinical Signs ◽

Single Layer ◽

Ciliated Epithelium ◽

The Central Nervous System ◽

Well Differentiated ◽

The Right ◽

Plexus Papilloma

A 6-year-old female Cocker Spaniel with a choroid plexus papilloma had clinical signs of disease of the central nervous system for 1 month. The neoplasm originated from the right choroid plexus of the fourth ventricle and had displaced contiguous parts of the medulla oblongata and cerebellum. It was well differentiated and was composed of papillae arranged in an arboriform pattern. The papillae were lined by a single layer of non ciliated epithelium.

Download Full-text

Choroid plexus tumours

The Neurosurgeon's Handbook ◽

10.1093/med/9780198570677.003.0308 ◽

2010 ◽

pp. 408-412

Author(s):

George Samandouras

Keyword(s):

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Choroid Plexus Carcinoma ◽

Plexus Papilloma

Chapter 8.6 covers choroid plexus tumours, including choroid plexus papilloma (CPP) and choroid plexus carcinoma (CPC).

Download Full-text

Choroid plexus tumours

10.1093/med/9780199651870.003.0006 ◽

2017 ◽

Author(s):

Maria Santos ◽

Eric Bouffet ◽

Carolyn Freeman ◽

Mark M. Souweidane

Keyword(s):

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Choroid Plexus Carcinoma ◽

Adjuvant Radiation ◽

Li Fraumeni Syndrome ◽

Central Nervous System Tumours ◽

Histological Criteria ◽

Wide Range ◽

Plexus Papilloma

Choroid plexus tumours are rare, intraventricular, primary central nervous system tumours derived from the choroid plexus epithelium. They occur predominantly in children and are classified based on histological criteria as choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma. Choroid plexus carcinomas can occur in the context of Li–Fraumeni syndrome, where the TP53 germline mutation predisposes patients to a wide range of neoplasms. Treatment of these tumours is challenging, due to their high vascularity and the young age of the patients. While surgery is the mainstay of treatment of all choroid plexus tumours, the exact role of adjuvant therapy, particularly in choroid plexus carcinoma, is still unclear. For incompletely resected tumours, there is evidence that neoadjuvant chemotherapy can facilitate second-look surgery and reduce the risk of intraoperative bleeding. However, the role of adjuvant radiation after complete resection remains unclear.

Download Full-text

A Meta-Analysis of Choroid Plexus Papilloma (CPP) and Choroid Plexus Carcinoma (CPC)

Pediatric Research ◽

10.1203/00006450-199904020-00902 ◽

1999 ◽

Vol 45 (4, Part 2 of 2) ◽

pp. 152A-152A ◽

Cited By ~ 1

Author(s):

Mitra Sagidi ◽

Max J Coppes ◽

R Maarten Egeler ◽

U Gesche Tallen ◽

Ronald Anderson ◽

...

Keyword(s):

Choroid Plexus ◽

Meta Analysis ◽

Choroid Plexus Papilloma ◽

Choroid Plexus Carcinoma ◽

Plexus Papilloma

Download Full-text

Choroid Plexus Papilloma with Dandy Walker Variant: Co-existence or Association- A Case Report

Bangladesh Medical Journal ◽

10.3329/bmj.v46i2.40222 ◽

2019 ◽

Vol 46 (2) ◽

pp. 61-65

Author(s):

Mohammad Hossain ◽

Nazmin Ahmed ◽

Narendra Shalike ◽

Md Rokibul Islam ◽

Soumen Samadder ◽

...

Keyword(s):

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Communicating Hydrocephalus ◽

Intermediate Form ◽

Genetic Syndromes ◽

Who Grade ◽

Choroid Plexus Tumors ◽

Well Differentiated ◽

Central Nervous Sytem ◽

Plexus Papilloma

Choroid plexus tumors are rare intracranial tumors which account for 0.4-0.6% of all brain tumors. Choroid plexus tumors represent a spectrum of neoplasms derived from papillary epithelium of normal choroid plexus, including well-differentiated papilloma (WHO grade I), intermediate form as atypical Choroid Plexus Papilloma (WHO grade II) and highly aggressive choroid plexus carcinomas (WHO grade III). Though rare, it is responsible for the communicating hydrocephalus in children due to overproduction of cerebrospinal fluid. Due to advances in molecular biology and better understanding of the tumorigenesis of choroid plexus papilloma, now it is established that several genetic syndromes and central nervous sytem abnormalities are associated with this tumor. Here, we reported a case of a 10 months old child who presented with sudden deterioration of consciousness level and after thorough evaluation, diagnosed as a case of Choroid Plexus Papilloma with Dandy Walker Variant. Till date, this is the first reported case of the association/ co-existence of such two conditions which needs further evaluation. Bangladesh Med J. 2017 May; 46 (2): 61-65

Download Full-text

Final results of the Choroid Plexus Tumor study CPT-SIOP-2000

Journal of Neuro-Oncology ◽

10.1007/s11060-021-03942-0 ◽

2022 ◽

Author(s):

Johannes E. Wolff ◽

Stefaan W. Van Gool ◽

Tezer Kutluk ◽

Blanca Diez ◽

Rejin Kebudi ◽

...

Keyword(s):

High Risk ◽

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Progression Free Survival ◽

Choroid Plexus Carcinoma ◽

Free Survival ◽

Intention To Treat ◽

Extent Of Surgery ◽

To Receive ◽

Plexus Papilloma

Abstract Introduction Standards for chemotherapy against choroid plexus tumors (CPT) have not yet been established. Methods CPT-SIOP-2000 (NCT00500890) was an international registry for all CPT nesting a chemotherapy randomization for high-risk CPT with Carboplatin/Etoposide/Vincristine (CarbEV) versus Cyclophosphamide/Etoposide/Vincristine (CycEV). Patients older than three years were recommended to receive irradiation: focal fields for non-metastatic CPC, incompletely resected atypical choroid plexus papilloma (APP) or metastatic choroid plexus papilloma (CPP); craniospinal fields for metastatic CPC/APP and non-responsive CPC. High risk was defined as choroid plexus carcinoma (CPC), incompletely resected APP, and all metastatic CPT. From 2000 until 2010, 158 CPT patients from 23 countries were enrolled. Results For randomized CPC, the 5/10 year progression free survival (PFS) of patients on CarbEV (n = 20) were 62%/47%, respectively, compared to 27%/18%, on CycEV (n = 15), (intention-to-treat, HR 2.6, p = 0.032). Within the registry, histological grading was the most influential prognostic factor: for CPP (n = 55) the 5/10 year overall survival (OS) and the event free survival (EFS) probabilities were 100%/97% and 92%/92%, respectively; for APP (n = 49) 96%/96% and 76%/76%, respectively; and for CPC (n = 54) 65%/51% and 41%/39%, respectively. Without irradiation, 12 out of 33 patients with CPC younger than three years were alive for a median of 8.52 years. Extent of surgery and metastases were not independent prognosticators. Conclusions Chemotherapy for Choroid Plexus Carcinoma is feasible and effective. CarbEV is superior to CycEV. A subset of CPC can be cured without irradiation.

Download Full-text

Primary choroid plexus papilloma of the sacral nerve roots

Journal of Neurosurgery Spine ◽

10.3171/2008.10.spi08277 ◽

2009 ◽

Vol 10 (1) ◽

pp. 51-53 ◽

Cited By ~ 8

Author(s):

Renzo Boldorini ◽

Gabriele Panzarasa ◽

Paola Girardi ◽

Guido Monga

Keyword(s):

Mr Imaging ◽

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Single Layer ◽

Complete Removal ◽

Nerve Roots ◽

Sacral Nerve ◽

Contrast Enhanced ◽

History Of ◽

Plexus Papilloma

The authors describe a unique case of a choroid plexus papilloma of the sacral nerve roots. This 60-year-old woman was admitted to the hospital because of a 1-year history of sacral pain, rectal and urinary bladder retention, and paradoxical episodic incontinence. Physical examination revealed sensory abnormalities in the S-2 dermatomes and poor rectal and bladder sphincter contractions. Contrast-enhanced spinal MR imaging showed a well-circumscribed, ovoid, homogeneously enhancing mass at the S1–2 level suggesting a diagnosis of ependymoma or schwannoma, and surgery allowed the identification and complete removal of a soft gray mass intimately adhering to the sacral nerve roots. Histological examination revealed a tumor consisting of papillary structures lined by a single layer of columnar cells, with an immunophenotype that satisfied the diagnostic criteria of choroid plexus papilloma. After diagnosis, contrast-enhanced brain MR imaging excluded the presence of a primary choroid plexus papilloma in the cerebral ventricles, thus ruling out a drop metastasis along the CSF pathways. A review of the literature did not reveal any similar cases of choroid plexus papilloma, and so the authors also discuss the inclusion of primary or metastatic papillary tumors in this unusual location as part of the differential diagnosis.

Download Full-text