Treatment Modalities for Infertile Patients with Polycystic Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory fertility problems in women of reproductive age, with a prevalence as high as 40% to 75%. There are different treatment modalities for increasing the chance of pregnancy in PCOS patients. Since most of the PCOS patients suffer from ovulatory problems, therapeutic efforts are focused mainly towards restoring normal ovulation. However, even after pharmacological interventions to ameliorate ovulatory irregularities, women with polycystic ovary are still at high risk of fetal loss. Thus, assisted reproductive techniques (ARTs) have become popular approaches which significantly increase the chances of successful pregnancy in these women, bypassing the conditions of PCOS. The present mini-review ‘pinpoints’ on the suitability of ARTs for PCOS patients who fail to ovulate following the conventional infertility treatment. The article also briefly explains how intracytoplasmic sperm injection (ICSI), the most effectiveART, correlates with better biological parameters, fertilization rate and better quality of embryos in PCOS women.

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Effects of bushen huatan recipe on the AKT-GLUT4 insulin signal pathway of ovarian granular cells in polycystic ovarian syndrome and IVF outcomes in these infertile patients

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.558 ◽

2018 ◽

Vol 110 (4) ◽

pp. e191

Author(s):

S. Xiang ◽

F. Lian

Keyword(s):

Polycystic Ovarian Syndrome ◽

Signal Pathway ◽

Granular Cells ◽

Insulin Signal ◽

Ivf Outcomes ◽

Infertile Patients ◽

Ovarian Syndrome

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Infertility Riding on Polycystic Ovarian Syndrome (PCOS): A Review of Treatment Modalities

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i54a33713 ◽

2021 ◽

pp. 1-14

Author(s):

Reenoo Jauhari ◽

Prashant Mathur ◽

Vineeta Gupta

Keyword(s):

Polycystic Ovarian Syndrome ◽

Follicular Development ◽

Reproductive Age ◽

Fertility Treatment ◽

Response To Treatment ◽

Lipid Lowering ◽

Treatment Modalities ◽

Comprehensive Treatment ◽

Lifestyle Modifications ◽

Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the commonest cause of anovulatory infertility. Depending on the population studied between 5 and 18% of women of reproductive age suffer from PCOS, however not all of them are anovulatory or experience subfertility. PCOS has been associated with numerous reproductive and metabolic abnormalities. Despite enormous advances in the management of reproductive dysfunction, insight into the metabolic implications of PCOS is limited by the lack of uniform diagnostic criteria, the heterogeneity of the condition and the presence of confounders including obesity. Obesity clearly has a role in long term health and may best predict both reproductive and metabolic dysfunction as well as negatively affect the response to treatment in women with PCOS. Diabetes, cardiovascular disease and cancer are also at the forefront of any risk assessment or comprehensive treatment strategy for these women. Lifestyle modifications including dietary changes, increased exercise and weight loss are appropriate first line interventions for many women with PCOS. Pharmaceuticals including metformin, lipid lowering agents and oral contraceptives should be tailored to the individual’s risk profile and treatment goals. The fertility treatment in women with subfertility and PCOS aimed to safely induce monofollicular ovulation resulting in the birth of a singleton child. Women with PCOS undergoing fertility treatment are at risk of multi-follicular development as well as ovarian hyper-stimulation syndrome (OHSS), so they must be carefully counselled and monitored during fertility treatment. It is imperative that prior to embarking on fertility treatment, a patient’s health and weight is optimised. This chapter will explore the latest evidence for fertility treatments for women with PCOS.

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Prevalence, Symptomatology and Herbal Management of Polycystic Ovarian Syndrome

10.5772/intechopen.95319 ◽

2020 ◽

Author(s):

Sabira Sultana ◽

Naheed Akhter ◽

Muhammad Akram ◽

Syed Muhammad Ali Shah ◽

Naveed Munir ◽

...

Keyword(s):

Polycystic Ovarian Syndrome ◽

Scientific Information ◽

Pituitary Hormones ◽

Mature Female ◽

Reproductive Age ◽

Tinospora Cordifolia ◽

Treatment Modalities ◽

Asparagus Racemosus ◽

Lepidium Meyenii ◽

Ovarian Syndrome

Polycystic Ovarian Syndrome (PCOS) is multi-organ syndrome that affects 6–25% of females during reproductive age. It disrupts normal hormone levels of females and affects adrenal hormone and sex hormones along with pituitary hormones including adrenocorticotropic, growth hormone and gonadotropins hormones. It results in several secondary characteristics in females such as infertility, hormonal imbalance, oligomenorrhea, amenorrhea, obesity and hirsutism. Polycystic ovarian syndrome is associated with mental and reproductive disorder and almost 4–18% mature female students are affected by polycystic ovarian syndrome. Female affected by polycystic ovarian syndrome have increased risk of infertility, ovarian cancer, skin problems and psychological problems such as anxiety, depression and changes in sleep along with mood swings. This chapter discusses the Prevalence, Symptomatology and Management of Polycystic Ovarian Syndrome. For the management of PCOS, the role of some medicinal plants including Asparagus racemosus, Tinospora cordifolia, Foeniculum vulgare, Ocimum tenuiflorum, Actaea racemosa, and Lepidium meyenii have also been discussed in addition to other treatment modalities. The literature data was searched out and compiled using relevant original research articles and reviews published and indexed in Google Scholar, Scientific Information Database, Elsevier, PubMed and Science Direct.

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Beneficial Effects of Addition of Glucocorticoid during Induction of Ovulation by Letrozole in Polycystic Ovarian Syndrome

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1180 ◽

2012 ◽

Vol 4 (2) ◽

pp. 85-89

Author(s):

Mosammat Rashida Begum ◽

Maruf Siddiqui ◽

Hosne Ara Baby ◽

Mariya Ehsan ◽

Mosammat Shahina Begum ◽

...

Keyword(s):

South Asian ◽

Polycystic Ovarian Syndrome ◽

Target Population ◽

Research Centre ◽

Induction Of Ovulation ◽

Medical College ◽

Beneficial Effects ◽

Baseline Characteristics ◽

Infertile Patients ◽

Ovarian Syndrome

ABSTRACT Objective The aim of the study was to explore the efficacy of glucocorticoid in folliculogenesis and ovulation during induction of ovulation by letrozole in polycystic ovarian syndrome (PCOS). Materials and methods This experimental study was conducted in Dhaka Medical College and Hospital and Infertility Care and Research Centre (ICRC) Dhaka, Bangladesh. Two hundred and eighty infertile patients with PCOS, who failed to ovulate by letrozole 10 mg/day for 5 days were the target population of this study. The patients received glucocorticoid (Dexamethasone) 0.5 mg every alternate day from D2 of the cycle till D10 along with same dose of letrozole in subsequent cycles. Only letrozole-treated cycles were taken as control and letrozole plus glucocorticoid-treated cycles were taken as experimental. Monitoring was done by transvaginal ultrasonography. Six ovulatory cycles were observed for pregnancy. Main outcome measures were ovulation and pregnancy. Results Baseline characteristics were similar as same patients were taken as control and experimental. One hundred and eighty-two (65%) patients were ovulated and 93 (33.21%) patients got pregnant after addition of glucocorticoid. Conclusion In PCOS addition of glucocorticoid during induction of ovulation appears to cause significant improvement in folliculogenesis, ovulation and pregnancy. How to cite this article Begum MR, Ehsan M, Begum MS, Khan F, Baby HA, Siddiqui M, Quadir E. Beneficial Effects of Addition of Glucocorticoid during Induction of Ovulation by Letrozole in Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2012;4(2):85-89.

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