Association of Vitamin D Receptor Ggene Ppolymorphisms and Type 1 diabetes in Egyptian Population.

The human vitamin D receptor (VDR) gene is located on chromosome 12q12–q14, and four commonnucleotide polymorphisms have been identified. Several studies have found a relationship betweenpolymorphisms of the (VDR) gene and development of type 1 diabetes (T1DM). The association ofVDR polymorphisms and susceptibility to T1DM in the Egyptian population were examined in 60individuals with type 1 diabetes and compared with healthy 60 persons. Single nucleotidepolymorphisms (SNP) genotyping was performed using PCR and BsmI and FokI, by using twotechniques, allele specific PCR technique and restriction fragment length polymorphism – PCR(RFLP-PCR). Data were analyzed using the chi square. The result approved that the genotype TA inSNP FokI was risk factor among type 1 diabetes mellitus patients combination which conferredstrongest susceptibility to T1DM (P=0.004) while the SNP BsmI did not showed any significancebetween cases as compared with control (P=0.493). The results of the current study indicated that VDRpolymorphisms are associated with increased risk of T1DM in the Egyptian population. The differencein the association of the aforementioned SNPs variants with T1DM among different populations maybe attributed to the presence of multiple susceptibility alleles.

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Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis

Endocrine Connections ◽

10.1530/ec-16-0110 ◽

2017 ◽

Vol 6 (3) ◽

pp. 159-171 ◽

Cited By ~ 22

Author(s):

Ozlem Atan Sahin ◽

Damla Goksen ◽

Aysel Ozpinar ◽

Muhittin Serdar ◽

Huseyin Onay

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Receptor ◽

Meta Analysis ◽

Vdr Gene ◽

Increased Risk ◽

Funnel Plots ◽

Type 1 Dm ◽

Study Inclusion

Background There have been studies focused on FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results. Methods This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age. Results A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB (P < 0.05), BsmIBb, (P < 0.05), BsmIbb (P < 0.05), TaqITT (P < 0.05) and TaqItt (P < 0.05) in children. Conclusion The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of type 1 DM, whereas BsmIbb and TaqITT had protective effect for type 1 DM in children.

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Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus

Autoimmunity ◽

10.3109/08916934.2013.795952 ◽

2013 ◽

Vol 46 (6) ◽

pp. 382-387 ◽

Cited By ~ 15

Author(s):

Jaqueline De Azevêdo Silva ◽

Rafael Lima Guimarães ◽

Lucas André Cavalcanti Brandão ◽

Jacqueline Araujo ◽

Ludovica Segat ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Vdr Gene Polymorphisms

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Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

10.21203/rs.2.20545/v1 ◽

2020 ◽

Author(s):

Masoud Hassanzadeh Makoui ◽

Saeed Aslani ◽

Payam Mohammadi ◽

Bahman Razi ◽

danyal imani

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Vdr Gene ◽

Vdr Gene Polymorphisms

Abstract Objective The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of Type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to July 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted.Results A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI genes polymorphism and T1DM in African and American populations, respectively.Conclusions This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus

Acta Endocrinologica ◽

10.1530/eje.0.1470803 ◽

2002 ◽

pp. 803-808 ◽

Cited By ~ 57

Author(s):

B Gyorffy ◽

B Vasarhelyi ◽

D Krikovszky ◽

L Madacsy ◽

A Tordai ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Receptor ◽

Vdr Gene ◽

Vdr Polymorphism ◽

The Impact ◽

Vdr Polymorphisms

OBJECTIVE: Recent data have indicated the significance of vitamin D receptor (VDR) polymorphisms in type 1 diabetes mellitus (T1DM). We have studied the association of five known restriction enzyme polymorphisms of the VDR gene in patients with T1DM. DESIGN AND METHODS: One hundred and seven children with T1DM (T1DM for 5 Years; age, 1-14 Years; boys/girls, 57/50; body mass index, 17.0+/-2.3 kg/m(2); haemoglobin A(Ic) (HbA(Ic)), 7.87+/-1.05) and 103 healthy subjects were enrolled. The VDR polymorphisms ApaI, BsmI, FokI, TaqI and Tru9I ("a", "b", "f", "t" and "u" alleles respectively) were investigated. RESULTS: The "t" and "T" alleles miss the Hardy-Weinberg equilibrium (P<0.01) in control and diabetic populations; we therefore excluded this polymorphism from further analysis. We did not find a difference in the allele prevalence in T1DM patients and controls of any of the five polymorphisms. However, when the "b", "a" and "u" alleles were simultaneously compared in girls, there was a significantly higher prevalence in patients with diabetes compared with controls ("b"+"a"+"u" present/absent: healthy, 0/53; diabetic, 13/37; P<0.005). In boys the prevalence of "b"+"a"+"u" genotype was similar in T1DM and controls. CONCLUSIONS: The impact of the "t" allele cannot be investigated in this study population. Not a single VDR polymorphism increases the susceptibility to T1DM. The common presence of the "b", "a" and "u" alleles greatly increases the probability of T1DM in girls.

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Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

10.21203/rs.2.20545/v2 ◽

2020 ◽

Author(s):

Na Zhai ◽

Ramtin Bidares ◽

Masoud Hassanzadeh Makoui ◽

Saeed Aslani ◽

Payam Mohammadi ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Vdr Gene ◽

Vdr Gene Polymorphisms

Abstract Background: The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM. Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to March 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in African and American populations, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction

Multiple Sclerosis Journal ◽

10.1177/1352458509102459 ◽

2009 ◽

Vol 15 (5) ◽

pp. 563-570 ◽

Cited By ~ 61

Author(s):

JL Dickinson ◽

DI Perera ◽

AF van der Mei ◽

A-L Ponsonby ◽

AM Polanowski ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Vitamin D Receptor ◽

Significant Interaction ◽

Important Determinant ◽

Sun Exposure ◽

Population Based ◽

Vdr Gene ◽

Increased Risk ◽

Group 2

Multiple studies have provided evidence for an association between reduced sun exposure and increased risk of multiple sclerosis (MS), an association likely to be mediated, at least in part, by the vitamin D hormonal pathway. Herein, we examine whether the vitamin D receptor ( VDR), an integral component of this pathway, influences MS risk in a population-based sample where winter sun exposure in early childhood has been found to be an important determinant of MS risk. Three polymorphisms within the VDR gene were genotyped in 136 MS cases and 235 controls, and associations with MS and past sun exposure were examined by logistic regression. No significant univariate associations between the polymorphisms, rs11574010 ( Cdx-2A > G), rs10735810 ( Fok1T > C), or rs731236 ( Taq1C > T) and MS risk were observed. However, a significant interaction was observed between winter sun exposure during childhood, genotype at rs11574010, and MS risk ( P = 0.012), with the ‘G’ allele conferring an increased risk of MS in the low sun exposure group (≤2 h/day). No significant interactions were observed for either rs10735810 or rs731236, after stratification by sun exposure. These data provide support for the involvement of the VDR gene in determining MS risk, an interaction likely to be dependent on past sun exposure.

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The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

BioMed Research International ◽

10.1155/2013/295791 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Bahar Toptaş ◽

Ali Metin Kafadar ◽

Canan Cacina ◽

Saime Turan ◽

Leman Melis Yurdum ◽

...

Keyword(s):

Vitamin D ◽

Cancer Patients ◽

Vitamin D Receptor ◽

Brain Cancer ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Increased Risk ◽

Vdr Gene Polymorphisms ◽

Significant Difference ◽

Healthy Control

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma.Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP).Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles.Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.

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