scholarly journals Synthesis of Heterocyclic Compounds Containing Sulphur From Ethylene Diamine Tetra Acetic acid Derivatives

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1006-1011
Author(s):  
Khudheyer Jawad Kadem
Keyword(s):  
Carbonyl Group ◽  
Heterocyclic Compounds ◽  
Thioglycolic Acid ◽  
Biological Activities ◽  
Ethylene Diamine ◽  
Mercaptoacetic Acid ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Ft Ir ◽  
Set Up

In this work, three novel Schiff's bases subsidiaries were set up from Ethylene Diamine Tetra Acetic corrosive Derivatives(K1, K2 and K3); (K1) which was blend from response of EDTA with 4-hydroxybenzaldehyde and 2,4-dintrophenyl hydrazine. (K2) which was union from response of EDTA with vinilline and 2,4-dintrophenyl hydrazine. (K3) which was amalgamation from response of EDTA with 4-aminoacetophenone and 2,4-dintrophenyl hydrazine after that combination three novel hetrocyclic compound Containing Sulfur molecule; Derivative with compounds containing carbonyl group (aldehyde or ketone) the carbonyl group of aldehyde or ketone react with primary amine to produce mine compounds (Schiff bases), Reaction of produced Schiff base compounds with mercaptoacetic acid (thioglycolic acid) to synthesized new heterocyclic compounds Compounds with heterogeneous ring are characterized by having many biological activities Which attracts the attention of researchers, and accordingly various derivatives containing sulfur were prepared for heterocyclic compounds, these prepared compounds can have inhibitory activity for some bacteria, fungi, and viruses. (M1,M2 and M3)which were union from response of (K1,K2 and K3) individually with marcaptoacetic acid. All of the Schiff’s bases derivatives and hetrocyclic compound Containing Sulphur atom were characterized and identified by spectroscopic methods ( FT-IR and 1H-NMR) spectroscopies.

scholarly journals Synthesis and Characterization of New Heterocyclic Compounds from Calix [4] arene Derivative

2020 ◽  
Vol 11 (3) ◽  
pp. 3143-3150
Author(s):  
Khudheyer Jawad Kadem
Keyword(s):  
Carbonyl Group ◽  
Primary Amine ◽  
Heterocyclic Compounds ◽  
Aminobutyric Acid ◽  
Mercaptoacetic Acid ◽  
Arene Derivative ◽  
Leaving Group ◽  
Acid Reaction ◽  
Ft Ir

In this work, a new heterocyclic compounds derived from Calix[4]arene Derivative had been synthesized. The characterization of the produced compounds was performed using melting point, FT-IR spectroscopy and some of them with 1H-NMR spectroscopy. The spectral data confirm the formation of these compounds. This research includes the following two parts:- Part 1: Synthesis of Calix[4]arane Derivative from reaction Calix[4]arane with 4- Aminobutyric acid to produce ester compound this part4-Aminobutyric acid reaction with freshly distilled thinly chloride , the produce final was purified via distillation below pressure reduced. The product was purified by repeated recrystallization. In this step Converted the substituted carboxylic acid to substituted acid chloride included to obtained good leaving group the compound product containing primary amine and the reaction of Calix[4]arane Derivative with compounds containing carbonyl group(aldehyde or ketone) the carbonyl group of aldehyde or ketone react with primary amine to produce imine compounds(Schiff bases. Part 2: Reaction of produced Schiff base compounds with mercaptoacetic acid (thioglycolic acid) or maleic anhydride to synthesized new heterocyclic compounds Compounds with heterogeneous ring are characterized by having many biological activitiesWhich attracts the attention of researchers, and accordingly various derivatives containing sulfur or oxygen were prepared for heterocyclic compounds, these prepared compounds can have inhibitory activity for some bacteria, fungi, and viruses.

Synthesis and Biological Activities of Some Schiff's Bases from 4-amino-3-(3-hydroxybutyl)-1H-1, 2, 4-triazole-5-thione

2009 ◽  
Vol 2009 (4) ◽  
pp. 208-211 ◽  
Author(s):  
Jing Zhang ◽  
Lixue Zhang ◽  
Xinxiang Lei ◽  
Changfeng Zhou ◽  
Xiaodan Fu ◽  
...  
Keyword(s):  
Plant Growth ◽  
Elemental Analysis ◽  
Mass Concentration ◽  
Biological Activities ◽  
Schiff’S Bases ◽  
H Nmr ◽  
Schiff's Bases ◽  
High Yields ◽  
C Nmr ◽  
Growth Regulating Activity

Sixteen novel Schiff's bases have been synthesised in high yields from 4-amino-3-(3-hydroxybutyl)-1 H-1, 2, 4-triazole-5-thione. All the newly synthesised compounds have been characterised by elemental analysis, IR, 1H NMR, 13C NMR and MS. Plant growth-regulating activity tests showed that most compounds have remarkable effects on the growth of wheat and radish at a mass concentration of 50μg mL−1.

scholarly journals Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases

2020 ◽  
Vol 63 (1) ◽  
pp. 1-11
Author(s):  
Amena Alyas Ahmed ◽  
Natiq Ghanim Ahmed ◽  
Ahmad Khuder Ahmad
Keyword(s):  
Acetic Acid ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Glacial Acetic Acid ◽  
Thioglycolic Acid ◽  
Absolute Ethanol ◽  
13C Nmr Spectra ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Tetrazole Derivatives

  The present work involved the synthesis of compound (1) (1-amino-4-methyl-6-phenyl pyrimidine- 2-(1H)-thione). This compound reacts with different aromatic aldehyde using glacial acetic acid as catalytic on absolute ethanol to give a new series of Schiff's bases (2-7). New thiazolidine-4-one were prepared from reactions of Schiff's bases (2,3,4,7) with thioglycolic acid in absolute ethanol giving compounds (8-11). Finally the preparation of new tetrazole derivatives (12-15) by reaction of Schiff's bases (2,3,4,7) with sodium azide in THF. The structure of the synthesized compounds are confirmed by I.R., 1H-NMR and 13C-NMR spectra and some physical  data.  

scholarly journals Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes

2021 ◽  
Vol 37 (1) ◽  
pp. 187-193
Author(s):  
D. G. Anuse ◽  
V. J. Desale ◽  
B. R. Thorat ◽  
D. D. Anuse ◽  
S. G. Jagadhani ◽  
...  
Keyword(s):  
Metal Complex ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Zinc Chloride ◽  
Biological Activities ◽  
Biologically Active ◽  
Lanthanum Chloride ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Derivatives Of

The substituted 2-Aminobenzothiazole and ethyl 2-(4-formyl-3-hydroxyphenyl)-4-methylthiazole-5-carboxylate in methanol mix together and heat the reaction mixture for overnight, It gives Schiff’s bases (derivatives of substituted aminobenzothiazole) 3. This compound 3 when treated with Zinc Chloride it gives Zinc metal complex of Schiff’s bases 4 and if compound 3 was treated with Lanthanum chloride gives Lanthanum metal complex of Schiff’s bases 5, which shows marked biological activities.

MICROWAVE ASSISTED SYNTHESIS OF BIPHENYL BASED SCHIFF’S BASES AND THEIR ANTIMICROBIAL EVALUATION

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (03) ◽  
pp. 13-18
Author(s):  
R. Somani ◽  
◽  
P. Dubey ◽  
S. Zine
Keyword(s):  
Biological Activities ◽  
Biological Membrane ◽  
Log P ◽  
Microwave Assisted Synthesis ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Schiff's Bases ◽  
Phenyl Rings ◽  
Antimicrobial Evaluation ◽  
Anti Fungal

Schiff’s base constitutes a significant class of compounds for new drug development. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The search for Schiff’s base containing compounds with more selective activity and lower side effects continues to be an active area of argument examination in medicinal chemistry. The biphenyl molecule consists of two connected phenyl rings. Biphenyl ring scaffolds are fairly non-reactive in nature. They enhance the log-P values; increase the tropical polar surface area (TPSA) of the molecule, act as hydrophobic carrier across biological membrane, thus, increasing the bioavailability of compounds. In the present work, a series of Schiff’s bases of biphenyl-4-carboxylic acid have been synthesized. These derivatives were characterized by elemental analysis, IR, and 1H NMR spectral data and have been explored for anti-bacterial, anti-fungal and anti-tubercular activities. The synthesized compounds have shown excellent anti-fungal potential, making them good candidates for future studies in antifungal research.

A novel acyl hydrazone schiff’s bases of benzimidazole-2-thiol

2021 ◽  
Vol 10 (4) ◽  
pp. 151-155
Author(s):  
Amir Hassan ◽  
Nawaz Khan
Keyword(s):  
Acetic Acid ◽  
Biological Activities ◽  
Schiff’S Bases ◽  
Cool Water ◽  
Schiff's Bases ◽  
Acyl Hydrazone ◽  
Derivatives Of

A series of novel acyl hydrazone derivatives of benzimidazole-2-thiol were synthesized. The acylhydrazide was condensed with a series of aromatic substituted aldehydes to yield the tetra decylhydrazone Schiff”s bases of benzimidazole-2-thiol. The acylhydrazide was taken in methanol in round bottom flask added 2-3 drops acetic acid and refluxed on hotplate the reaction mixture was monitored with TLC. After completion of reaction the product was precipitated in ice cool water, washed and dried. The synthesized compounds were screened for different biological activities such as antimicrobial, antihistamine, neutropic, analgesic, antiprotozoal, antimalarial, antiallergic, antioxidant, anticonvulsant, anti-tubercular and have shown a good results.

scholarly journals Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’

2018 ◽  
Vol 8 (6-s) ◽  
pp. 424-428 ◽  
Author(s):  
Ansar R. Shaikh ◽  
Mazahar Farooqui ◽  
R.H. Satpute ◽  
Syed Abed
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Regulatory Standards ◽  
Class 1 ◽  
Structural Alerts ◽  
Regulatory Assessment ◽  
Novel Catalyst ◽  
Nitrogen Containing Compounds

Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant, antiallergic, herbicidal, anticancer activity. There is always a strong need for new and efficient processes in synthesizing of new Heterocycles.Alum have been used as a novel catalyst in the synthesis of Schiff’s bases. Synthesized Schiff’s bases are free from use of ICH class 1 and Class 2 solvents and also free from structural alerts genotoxic impurities. This review highlights on various aspects of heterocyclic compounds with its biological activity & regulatory assessment based on the ‘International Regulatory Standards’. Keywords: Heterocycles. Nitrogen containing compounds Biological activity, History, Regulatory assessment, International Regulatory Standards

s-Proline Covalented Silicapropyl Modified Magnetic Nanoparticles: Synthesis, Characterization, Biological and Catalytic Activity for the Synthesis of thiazolidin-4- ones

2020 ◽  
Vol 17 (6) ◽  
pp. 464-472
Author(s):  
Leila Zare Fekri
Keyword(s):  
Magnetic Nanoparticles ◽  
Thioglycolic Acid ◽  
Biological Activities ◽  
Aqueous Media ◽  
Catalytic Efficiency ◽  
Catalytic Method ◽  
Catalytic Application ◽  
Solvent Free Conditions ◽  
Ft Ir ◽  
Modified Magnetic Nanoparticles

Background: Thiazolidinoneones are important pharmaceutical compounds because of their biological activities. Several methods for the synthesis of 4-thiazolidinones are widely reported in the literature. The main synthetic routes to synthesize 1,3-thiazolidin-4-ones involve three components reaction between amine, a carbonyl compound and thioglycolic acid. Objective: s-Proline covalented silicapropyl modified magnetic nanoparticles (Fe3O4@SiO2-Pr @s-proline) were prepared. The antibacterial activity of synthesized nanoparticles against four bacterias was investigated that showed that 30 Mg/L of synthesized nanoparticles is a suitable concentration for bacterial inhibitory. Finally, the catalytic application of the synthesized s-Proline covalented silicapropyl modified magnetic nanoparticles for the synthesis of thiazolidinones and pyrazolyl thiazolidinones under stirring in aqueous media was evaluated. All of the synthesized organic compounds were characterized by mp, FT IR, 1H NMR, 13C NMR and elemental analysis. Materials and Methods: A combination of aldehyde (1.0 mmol), thioglycolic acid (1.0 mmol), various amines (1mmol) and 0.05 g Fe3O4@SiO2propyl@L-proline, were reacted at room temperature under stirring in 10 mL water. After completion of the reaction, as indicated by TLC (4:1 hexane: ethylacetate), the reaction mixture was filtered in the presence of an effective magnetic bar to separate the nanocatalyst. The nanocatalyst was washed with a mixture of hot EtOH: H2O two times. The crude products were collected and recrystallized from ethanol, if necessary. Results and Discussion: We present a novel avenue for the synthesis of thiazolidinones in the presence of Fe3O4@SiO2-Pr @s-proline under solvent-free conditions. Conclusion: In conclusion, we have synthesized Fe3O4@SiO2-Pr@s-proline nanoparticles. Their biological activity against 4 bacterias was investigated. It released that 30Mg/L is the suitable concentration of synthesized nanoparticle for bacterial inhibitory. The catalytic efficiency of the catalyst was checked in the multicomponent reaction of various aldehyde, thioglycolic acid and various amines under stirring. This nanoparticle is a new organic-inorganic hybrid nanoparticle. The operational simplicity, the excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and high selectivity are the main advantages of this catalytic method. Furthermore, this new avenue is inexpensive and environmentally benign.

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