scholarly journals EPIDEMIOLOGI DAN DIAGNOSIS KEDOKTERAN LABORATORIK INFEKSI VIRUS H1N1

2018 ◽  
Vol 16 (3) ◽  
pp. 140
Author(s):  
J Sembiring ◽  
O Sianipar
Keyword(s):  
Sore Throat ◽  
Influenza A ◽  
Clinical Symptoms ◽  
H1n1 Virus ◽  
Antiviral Treatment ◽  
H1n1 Infection ◽  
Rt Pcr ◽  
Virus Family ◽  
Infection Diagnosis ◽  
Influenza A H1n1

H1N1 virus is an influenza virus family orthomyxoviridae, which clinical symptoms consist of: fever, cough, sore throat and headache. The virus can spread from person to person through airborne droplets and so a good infection control in the community or in healthworkers is needed, for instance by washing hands properly and PPE (Personal Protective Equipment). In October 4, 2009 there were over375.000 reported cases in which 4500 people were died. On June 11, 2009 the WHO stairs announced that H1N1 is the first pandemicin the 21st century. (The Indonesia people province was infecting by H1N1with 20 deaths until August 5, 2009). The purpose of thisarticle is to find out the epidemiological aspects as well as the diagnosis of influenza A H1N1 virus. From the website was found about1.110.000 sources, and after downloading them are selected as they are written only in the bibliography. From the searched informationobtained, it was known that H1N1 infection diagnosis begins with the discovery of heat (temperature ≥ 100° F [37.8° C]) and cough or sore throat. No cause other than influenza that is called with ILI was found. The informed laboratory examination is divided into three parts are confirmed if ILI was found as well as the virus in the throat or nasal swab by RT-PCR and/or virus culture; probably the ILIhas positive results of influenza A RT-PCR, but if the results are negative including the laboratorial findings, the basis of epidemiologyin this case was only suspected. Laboratory plays an important role in the establishing of the H1N1 infection diagnosis Rapid diagnosisis important to reduce infection, to protect patients from complications by antiviral treatment in the right time and also to provideimmediate information for the public.

Persistent mania and psychosis in a case of novel influenza a (H1N1) virus encephalitis

2011 ◽  
Vol 26 (S2) ◽  
pp. 406-406 ◽  
Author(s):  
J.Y. Teng ◽  
T.-S. Lee
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
Antiviral Treatment ◽  
Acute Infection ◽  
Psychotic Symptoms ◽  
Reye Syndrome ◽  
H1n1 Infection ◽  
Sequence Of Events ◽  
Influenza A H1n1 ◽  
Novel Influenza A

Neurologic complications associated with novel influenza A (H1N1) virus infection include seizures, encephalitis, encephalopathy and Reye syndrome. Mania and psychotic episodes are less commonly described, and there have been limited studies on the long-term neuropsychiatric sequelae of H1N1 infection.Here, we report a case of H1N1 infection with concurrent onset of acute manic and psychotic symptoms. Despite completing a full course of the antiviral medication oseltamivir, the patient's behaviour worsened over the next four weeks and he required readmission for psychiatric treatment. Based on the temporal sequence of events, we considered the possibility that these symptoms were sequelae of Novel influenza A (H1N1) infection. Moreover, the manic symptoms persisted weeks after the acute infection had abated, which gives rise to the consideration of long-lasting direct or indirect neuronal insult by the influenza virus. However, it is also possible that his symptoms may have represented a primary psychiatric disorder precipitated by or coincident with the viral infection.After treatment with antipsychotic medication and a mood stabiliser, his manic and psychotic symptoms became significantly attenuated. His behaviour improved considerably such that he was able to return to school. Medications were stopped after one month of outpatient follow-up at his behest. Four months after discharge, he was completely free of symptoms and was performing well in school.Treatment of influenza with antiviral medications has been shown to reduce the rate of complications. However, the effectiveness of antiviral treatment to prevent influenza-associated neuropsychiatric sequelae is unknown.

Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger and Tangerine peel prevent the H1N1 virus infections in mice

2021 ◽  
Author(s):  
Diqi Yang ◽  
Minghua Hu ◽  
Hongmei Zhu ◽  
Jianguo Chen ◽  
Dehai Wang ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Symptoms ◽  
H1n1 Virus ◽  
Global Public Health ◽  
Virus Infections ◽  
Shiitake Mushroom ◽  
Virus Challenge ◽  
Influenza A H1n1 ◽  
Public Health Challenges ◽  
Cellular Immune

Abstract The pandemic influenza A (H1N1) virus spread globally and posed one of the most serious global public health challenges. The traditional Chinese medicine is served as a complementary treatment strategy with vaccine immunization. Here, we demonstrated the mixed polysaccharides (MPs) derived from shiitake mushroom, poriacocos, ginger and tyangerine peel prevent the H1N1 virus infections in mice. MPs pretreatment attenuated H1N1 virus-induced weight loss, clinical symptoms and death. The lymphocytes detection results showed the CD3+, CD19+ and CD25+ cell proportions were up-regulated in thymus under MPs pretreatment. Besides, MPs pretreatment reduced the inflammatory cell infiltration and increased the cell proportions of CD19+, CD25+ and CD278+ in lung. However, MPs treatment have no effective therapeutic effect after H1N1 virus challenge. The current study suggested that pretreatment with MPs could attenuate H1N1 virus-induced lung injury and up-regulate humoral and cellular immune responses in non- immunized mice.

Detection of novel influenza A(H1N1) virus by real-time RT-PCR

2009 ◽  
Vol 45 (3) ◽  
pp. 203-204 ◽  
Author(s):  
David M. Whiley ◽  
Seweryn Bialasiewicz ◽  
Cheryl Bletchly ◽  
Cassandra E. Faux ◽  
Bruce Harrower ◽  
...  
Keyword(s):  
Real Time ◽  
Influenza A ◽  
H1n1 Virus ◽  
Rt Pcr ◽  
Influenza A H1n1 ◽  
Novel Influenza A

scholarly journals Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania

Medicina ◽  
2011 ◽  
Vol 47 (1) ◽  
pp. 11-18 ◽  
Author(s):  
◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Symptom Onset ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Clinical Course ◽  
Antiviral Treatment ◽  
Course Of Illness ◽  
Influenza A H1n1 ◽  
Complicated Course

The objective of this study was to identify case characteristics and clinical course of the disease in patients hospitalized with 2009 pandemic influenza A (H1N1) infection during the first wave of the pandemic and to identify risk factors associated with the complicated course of illness. Material and methods. A retrospective study of adult cases of the laboratory-confirmed 2009 pandemic influenza A (H1N1) virus admitted to three hospitals in Kaunas between November 1, 2009, and March 15, 2010, was carried out. The main outcome measures were clinical characteristics, risk factors for complicated disease, treatment, and clinical course of the disease. Results. The study enrolled 121 of the 125 patients hospitalized due to 2009 pandemic influenza A (H1N1) virus infection. The median age was 31 years (range, 18–83); 5% of the patients were aged more than 65 years. Pregnant and postpartum women comprised 26% of all hospitalized cases. Nearly half (49.5%) of those who underwent chest radiography had findings consistent with pneumonia, which was bilateral in one-third of cases. The risk to have pandemic influenza complicated by pneumonia increased significantly with one-day delay from symptom onset to antiviral treatment (OR, 2.241; 95% CI, 1.354–3.710). More than half (57%) of the patients received antiviral treatment. In 45% of the treated patients, antiviral drugs were administered within 48 hours from symptom onset. Intensive care was required in 7.4% of the cases. The overall mortality was 5% (6/121). The median age of the patients who died was 43.5 years (range, 23–62); 4 patients had been previously healthy, 1 patient suffered from chronic lympholeukemia, and 1 patient was a pregnant woman. Conclusion. The 2009 pandemic influenza A (H1N1) caused considerable morbidity in a significant proportion of hospitalized adults. The main risk factor associated with the complicated course of illness was delayed antiviral treatment.

Dual and Triple Infections With Influenza A and B Viruses: A Case-Control Study in Southern Brazil

2019 ◽  
Vol 220 (6) ◽  
pp. 961-968 ◽  
Author(s):  
Tatiana Schäffer Gregianini ◽  
Ivana R Santos Varella ◽  
Patricia Fisch ◽  
Letícia Garay Martins ◽  
Ana B G Veiga
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Clinical Symptoms ◽  
Antiviral Treatment ◽  
Influenza Virus Infection ◽  
H3n2 Virus ◽  
Influenza Surveillance ◽  
Influenza B Virus ◽  
Influenza B ◽  
Influenza A H1n1

Abstract Influenza surveillance is important for disease control and should consider possible coinfection with different viruses, which can be associated with disease severity. This study analyzed 34 459 patients with respiratory infection from 2009 to 2018, of whom 8011 were positive for influenza A virus (IAV) or influenza B virus (IBV). We found 18 cases of dual influenza virus infection, including coinfection with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and influenza A(H3N2) virus (1 case), A(H1N1)pdm09 and IBV (6 cases), A(H3N2) and IBV (8 cases), and nonsubtyped IAV and IBV (3 cases); and 1 case of triple infection with A(H3N2), A(H1N1)pdm09, and IBV. Compared with 76 monoinfected patients, coinfection was significantly associated with cardiopathy and death. Besides demographic characteristics and clinical symptoms, we assessed vaccination status, antiviral treatment, timeliness of antiviral use, hospitalization, and intensive care unit admission, but no significant differences were found between coinfected and monoinfected cases. Our findings indicate that influenza virus coinfection occurs more often than previously reported and that it can lead to a worse disease outcome.

scholarly journals Evaluation of Serological Diagnostic Methods for the 2009 Pandemic Influenza A (H1N1) Virus

2011 ◽  
Vol 18 (3) ◽  
pp. 520-522 ◽  
Author(s):  
Jesse Papenburg ◽  
Mariana Baz ◽  
Marie-Ève Hamelin ◽  
Chantal Rhéaume ◽  
Julie Carbonneau ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Pandemic Influenza ◽  
Hemagglutination Inhibition ◽  
Influenza A ◽  
H1n1 Virus ◽  
Diagnostic Methods ◽  
Rt Pcr ◽  
Virus Diagnosis ◽  
Household Contacts ◽  
Influenza A H1n1

ABSTRACTSerology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71%;P= 0.016).

In vitro transcribed RNA molecules for the diagnosis of pandemic 2009 influenza A(H1N1) virus by real-time RT-PCR

2013 ◽  
Vol 193 (2) ◽  
pp. 487-491 ◽  
Author(s):  
Mario Bermúdez de León ◽  
Katia Peñuelas-Urquides ◽  
Miguel E. Aguado-Barrera ◽  
María José Currás-Tuala ◽  
Brenda L. Escobedo-Guajardo ◽  
...  
Keyword(s):  
Real Time ◽  
Influenza A ◽  
H1n1 Virus ◽  
Rt Pcr ◽  
Rna Molecules ◽  
Influenza A H1n1

Development of a real-time RT-PCR assay for a novel influenza A (H1N1) virus

2010 ◽  
Vol 163 (2) ◽  
pp. 470-473 ◽  
Author(s):  
Tao Jiang ◽  
XiaoPing Kang ◽  
Yongqiang Deng ◽  
Hui Zhao ◽  
Xiaofeng Li ◽  
...  
Keyword(s):  
Real Time ◽  
Influenza A ◽  
H1n1 Virus ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Influenza A H1n1 ◽  
Novel Influenza A

A SYBR Green I real-time RT-PCR assay for detection and differentiation of influenza A(H1N1) virus in swine populations

2009 ◽  
Vol 162 (1-2) ◽  
pp. 184-187 ◽  
Author(s):  
Shuo Liu ◽  
Guangyu Hou ◽  
Qingye Zhuang ◽  
Yuelong Shu ◽  
Jiming Chen ◽  
...  
Keyword(s):  
Real Time ◽  
Influenza A ◽  
H1n1 Virus ◽  
Sybr Green ◽  
Sybr Green I ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Influenza A H1n1

scholarly journals Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection

2012 ◽  
Vol 70 (5) ◽  
pp. 325-329 ◽  
Author(s):  
Paulo José Lorenzoni ◽  
Cláudia Suemi Kamoi Kay ◽  
Rosana Herminia Scola ◽  
Hipólito Carraro Júnior ◽  
Lineu Cesar Werneck
Keyword(s):  
Critically Ill ◽  
Muscle Biopsy ◽  
Critically Ill Patients ◽  
Influenza A ◽  
H1n1 Virus ◽  
Inflammatory Myopathy ◽  
H1n1 Infection ◽  
Influenza A H1n1 ◽  
2009 H1n1 ◽  
Muscle Biopsies

Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.

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